Multidrug resistant 1 (MDR1) C3435T and G2677T gene polymorphism: impact on the risk of acute rejection in pediatric kidney transplant recipients

Table 3 Association of combined genotypes (C3435T and G2677T) with AR in AR and none AR cases

Variable	AR (n = 36)	None AR (n = 47)	OR (95% CI)	P value
Variable	N (%)	N (%)	OR (95% CI)	P value
TT ₃₄₃₅ GG ₂₆₇₇	3 (8.3%)	10 (21.3%)	Reference
CC ₃₄₃₅ GT ₂₆₇₇	8 (22.2%)	6 (12.8%)	2.500 (0.918–6.806)	0.073
CC ₃₄₃₅ TT ₂₆₇₇	5 (13.9%)	6 (12.8%)	1.863 (0.647–5.363)	0.249
CT ₃₄₃₅ GG ₂₆₇₇	2 (5.6%)	7 (14.9%)	0.972 (0.298–3.172)	0.962
CT ₃₄₃₅ GT ₂₆₇₇	11 (30.6%)	6 (12.8%)	3.046 (1.155–8.033)	0.024
CT ₃₄₃₅ TT ₂₆₇₇	7 (19.4%)	2 (4.3%)	4.486 (1.375–14.639)	0.013
CC ₃₄₃₅ GG ₂₆₇₇	0 (0%)	1 (2.1%)	-	1
TT ₃₄₃₅ GT ₂₆₇₇	0 (0%)	6 (12.8%)	-	1
TT ₃₄₃₅ TT ₂₆₇₇	0 (0%)	3 (6.4%)	-	1

AR; acute rejection; N; number, OR; odds ratio, CI; confidence interval, C; cytosine, T; thymine, G; guanine. Logistic regression analysis was used. P < 0.05 is considered significant; OR < 1 is considered protective; OR > 1 is considered risky. Reference combined genotype was considered as TT ₃₄₃₅ GG ₂₆₇₇

ISSN: 1824-7288