Table 4 Comparison of tacrolimus doses and trough levels according to the C3435T and G2677T genotypes

Trough level (ng/ml)

1st month

7.9 (5.8-9)

7.3 (6-9.5)

7.8 (7-9.3)

0.9

7.6 (4.3–9.9)

7.9 (2.5-8)

7.6 (2.5–8.3)

0.896

2nd month

8 (6.3–9.4)

9.8 (7.2–10)

9.8 (7–11)

0.7

9.9 (5.2–10.3)

9.5 (5.2–10.3)

9.7 (6–10)

0.530

3rd month

8 (6.7–9.6)

8.5 (6.7–10.2)

9.2 (8.5–10.5)

0.083

9.2 (4.5–9.5)

9 (4.5–10)

7.5 (4.5-9)

0.012

4th month

7.2 (6-9.7)

9.3 (7.2–10.3)

9 (8–10)

0.2

9.3 (4.4–10)

8.3 (4.2–9.6)

7.7 (5.1–8.7)

0.081

5th month

7.4 (5–10)

8.4 (5-10.2)

8.2 (5-9.8)

0.2

8.4 (5-9.5)

8.3 (5-9.7)

7 (5-8.4)

0.135

6th month

6.6 (6-8.5)

7.4 (4.7–9.6)

7 (4.7–9.1)

0.1

7.4 (4.4-9)

7.2 (2.5-8)

6 (4.5–7.9)

0.850

Mean trough level of 1st 6 months (ng/ml)

8 (5.9–9.3)

8.5 (6.1–9.9)

8.65 (6.7–9.95)

0.154

9.18 (4.6–9.9)

8.51 (6.43–9.5)

7.98 (6.21–8.5)

0.043

TAC dose (mg/kg/day)

1st month

0.3 (0.2–0.3)

0.18 (0.15–0.2)

0.16 (0.14–0.18)

< 0.001

0.17 (0.08–0.23)

0.18 (0.1–0.26)

0.27 (0.14–0.3)

< 0.001

2nd month

0.27 (0.2–0.3)

0.18 (0.15–0.19)

0.18 (0.15–0.19)

< 0.001

0.17 (0.04–0.25)

0.18 (0.13–0.26)

0.26 (0.13–0.29)

< 0.001

3rd month

0.28 (0.2–0.31)

0.18 (0.15–0.2)

0.15 (0.13–0.19)

< 0.001

0.15 (0.04–0.23)

0.18 (0.11–0.25)

0.28 (0.13–0.3)

< 0.001

4th month

0.29 (0.18–0.3)

0.16 (0.13–0.24)

0.12 (0.08–0.16)

< 0.001

0.13 (0.04–0.21)

0.16 (0.07–0.2)

0.29 (0.12–0.3)

< 0.001

5th month

0.24 (0.17–0.3)

0.17 (0.13–0.19)

0.1 (0.06–0.17)

< 0.001

0.14 (0.05–0.22)

0.17 (0.06–0.21)

0.23 (0.1–0.26)

< 0.001

6th month

0.23 (0.18–0.3)

0.17 (0.13–0.23)

0.13 (0.08–0.15)

0.001

0.13 (0.07–0.2)

0.18 (0.04–0.22)

0.23 (0.1–0.25)

0.003

Mean TAC dose (mg/kg/day)

0.27 (0.2–0.32)

0.17 (0.15–0.2)

0.14 (0.12–0.19)

< 0.001

0.15 (0.055–0.22)

0.17 (0.115–0.23)

0.27 (0.12–0.28)

< 0.001

 C/D ratio (ng/ml/mg/kg/day)

1st month

25 (17.6–51.2)

49.5 (31.1–64.6)

54.3 (38.1–66.7)

0.002

51.18 (23.33–100.5)

40 (8.33–62.86)

35 (8.33–62.5)

0.024

2nd month

25.5 (23.8–50)

55.6 (43.9–72)

55 (35.6–71.4)

< 0.001

64.71 (18.67-80)

50 (20.83–77.22)

25.53 (9.43–79.23)

0.001

3rd month

26.9 (21.4–37.2)

45 (32.5–90)

65.4 (50.7-105.6)

< 0.001

65.38 (29.63-90)

40.63 (14.43–66.3)

26.92 (14.43–57.4)

< 0.001

4th month

27.1 (20.7–42.5)

49 (38-66.3)

72.7 (54.7–150)

< 0.001

66.25 (20.38–70.5)

42.86 (8.95–67.5)

27.08 (8.95–47.67)

< 0.001

5th month

30.4 (21.8–41)

41.2 (33.3–78.8)

69.2 (57.9-101.7)

< 0.001

60 (28-96.67)

41.18 (10.38–76.6)

25.16 (10.38–65.4)

< 0.001

6th month

30 (21.4–42.9)

43 (30.7–58.8)

58.8 (38.3–91)

0.001

56.3 (28.7–86.9)

42.9 (13.8–77.5)

26.7 (13.1–60.6)

0.002

Mean C/D ratio in 1st six months

30.2 (22.4–38.5)

47.3 (38.5–74)

68.1 (49.9-106.3)

< 0.001

68.1 (26.6–90)

47.3 (13–83)

29.2 (13-75.2)

< 0.001