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Table 5 Comparison between C3435T and G2677T genotypes regarding tacrolimus side effects

From: Multidrug resistant 1 (MDR1) C3435T and G2677T gene polymorphism: impact on the risk of acute rejection in pediatric kidney transplant recipients

Variables

N (%)

C3435T

CC (N = 26)

CT (N = 35)

TT (N = 22)

P value

Nephrotoxicity

5 (19.2%)

10 (28.6%)

5 (22.7%)

0.690

Neurotoxicity

1 (3.8%)

1 (2.9%)

5 (22.7%)

0.670

NODAT

0 (0%)

1 (2.9%)

0 (0%)

0.500

Dyslipidemia

1 (3.8%)

2 (5.7%)

1 (4.5%)

0.943

hirsutism

0 (0%)

1 (2.9%)

0 (0%)

0.500

G2677T

GG (N = 19)

GT (N = 44)

TT (N = 20)

P value

Nephrotoxicity

9 (39.1%)

8 (21.6%)

3 (13.0%)

0.105

Neurotoxicity

0 (0%)

1 (2.7%)

1 (4.3%)

0.622

NODAT

1 (4.3%)

0 (0%)

0 (0%)

0.554

Dyslipidemia

1 (4.3%)

2 (5.4%)

1 (4.3%)

0.975

hirsutism

1 (4.3%)

0 (0%)

0 (0%)

0.554

  1. TAC; tacrolimus, N; number, C; cytosine, T; thymine, G; guanine, NODAT; new onset diabetes after transplantation, Chi square test was used for comparison