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Table 7 Comparison of genetic variability in MDR 1 C3435T and G2677T between Egyptian health controls with controls from other studies

From: Multidrug resistant 1 (MDR1) C3435T and G2677T gene polymorphism: impact on the risk of acute rejection in pediatric kidney transplant recipients

 

MDR1 C3435T

First author/ Reference

Country

Control number

CC

CT

TT

C

T

HW p

FST vs.

current

Korkor et al.; [current]

Egypt

80

16

40

24

0.450

0.550

0.928

-

[49].

Jordan

116

24

60

32

0.466

0.534

0.671

< 0.001

[49].

Sudan

131

69

55

7

0.737

0.263

0.348

0.045

[50].

Morocco

100

39

51

10

0.645

0.355

0.256

0.038

[51].

Bahrain

184

64

84

36

0.576

0.424

0.376

0.016

[52].

Iran

200

40

105

55

0.463

0.538

0.429

< 0.001

[53].

Turkey

150

30

80

40

0.467

0.533

0.382

< 0.001

[54].

Egypt

200

68

103

29

0.598

0.403

0.317

0.022

[8].

France

81

29

34

18

0.568

0.432

0.193

0.014

[14].

Germany

188

53

90

45

0.521

0.479

0.576

0.005

 

MDR1 G2677T

First author/ Reference

Country

Control number

GG

GT

TT

G

T

HW p

FSTvs.

current

Korkor et al.; [current]

Egypt

80

39

28

13

0.663

0.338

0.052

-

[33].

Iran

120

78

25

0

0.879

0.121

0.161

0.066

[55].

China

200

35

75

42

0.477

0.523

0.892

0.035

[56].

Brazil

106

42

42

19

0.612

0.388

0.151

0.003

[57].

England

285

94

135

42

0.596

0.404

0.571

0.005

[58].

Korea

632

120

214

103

0.519

0.481

0.690

0.021

[59].

Scotland

370

102

174

94

0.511

0.489

0.256

0.024

  1. P value (P value number significant if ≤ 0.05). MRD1: multi drug resistant type 1, T: thymine, G: guanine, C; cytosine, Genotypes are expressed as number, alleles are expressed as frequencies; HW p, p value of Hardy Weinberg equation; Fst: Comparisons were done using pairwise fixation index (FST) comparison versus the current study