Articles

Omalizumab in children with severe allergic disease: a case series

Currently, severe allergic asthma and food allergy in children represent an important public health problem with medical, psychosocial and economic impacts. Omalizumab is a humanized monoclonal anti-IgE antibo...

Authors: Giuseppe Crisafulli, Lucia Caminiti, Fernanda Chiera, Stefania Arasi, Giuseppina Salzano, Ilenia Panasiti, Andrea Barbalace and Giovanni Battista Pajno

Malnutrition, morbidity and infection in the informal settlements of Nairobi, Kenya: an epidemiological study

Malnutrition constitutes one of the major public health challenges throughout the developing world. Urban poverty and malnutrition have been on the rise, with an increased rate of morbidity. We herein explore ...

Authors: Maria Vittoria De Vita, Carlo Scolfaro, Bruna Santini, Antonella Lezo, Federico Gobbi, Dora Buonfrate, Elizabeth W. Kimani-Murage, Teresiah Macharia, Milka Wanjohi, Jacopo Mattia Rovarini and Gianfranco Morino

Inequalities in infant mortality in Italy

All the children of the world should be born equal, but this is not so: even in Italy, there are striking differences already at birth. Neonatal and infant mortality are accurate indexes to assess the demograp...

Authors: Silvia Simeoni, Luisa Frova and Mario De Curtis

Novel DNA variation of GPR54 gene in familial central precocious puberty

Puberty can be considered the end point of a maturation process which is defined by the dynamic interactions of genes and environmental factors during prenatal and postnatal development. Kisspeptin/G protein-c...

Authors: Nosrat Ghaemi, Martha Ghahraman, Samaneh Noroozi Asl, Rahim Vakili, Fatemeh Fardi Golyan, Meysam Moghbeli and Mohammad Reza Abbaszadegan

Efficacy of the gluten free diet in the management of functional gastrointestinal disorders: a systematic review on behalf of the Italian Society of Paediatrics

Functional gastrointestinal disorders (FGIDs) are characterized by chronic/recurrent gastrointestinal symptoms not related to organic disorders. Due to the limited treatment options and to the perception of su...

Authors: Elena Scarpato, Renata Auricchio, Francesca Penagini, Angelo Campanozzi, Gian Vincenzo Zuccotti and Riccardo Troncone

Stage 4 s neuroblastoma: features, management and outcome of 268 cases from the Italian Neuroblastoma Registry

Infants diagnosed with stage 4 s neuroblastoma commonly experience spontaneous disease regression, with few succumbing without response to therapy. We analyzed a large cohort of such infants enrolled in the It...

Authors: Bruno De Bernardi, Andrea Di Cataldo, Alberto Garaventa, Paolo Massirio, Elisabetta Viscardi, Marta Giorgia Podda, Aurora Castellano, Paolo D’Angelo, Elisa Tirtei, Fraia Melchionda, Simona Vetrella, Francesco De Leonardis, Carmelita D’Ippolito, Annalisa Tondo, Antonella Nonnis, Giovanni Erminio…

Maternal HIV infection and preeclampsia increased risk of low birth weight among newborns delivered at University of Gondar specialized referral hospital, Northwest Ethiopia, 2017

Globally, more than 20 million infants are born with low birth weight. The risk of neonatal mortality among low birth weight infants is 25 to 30 times greater than neonates with birth weight ≥ 2500 g. Low birth w...

Authors: Daniale Tekelia Ekubagewargies, Destaye Guadie Kassie and Wubet Worku Takele

The effects of position on gastric residual volume of premature infants in NICU

Nutrition cares are of the main measures to save premature infants. In this regard, proper positioning is one of the key measures that is done by nurses; still there is a paucity of studies in this field and t...

Authors: Alireza Khatony, Alireza Abdi, Batol Karimi, Abbas Aghaei and Hamidreza Saeidi Brojeni

Authors’ reply - anaphylactic shock with methylprednisolone, Kounis syndrome and Hypersitivity to corticosteroids: a clinical paradox

In our letter, we comment the paper of Kounis et al., that highlights a poor-known clinical entity determined by systemic use of corticosteroids, the so-called “Kounis syndrome type I”. We appreciated and shar...

Authors: F. Porcaro, M. G. Paglietti, A. Diamanti, F. Petreschi, A. Schiavino, V. Negro, V. Pecora, A. Fiocchi and R. Cutrera

Survival and predictors among preterm neonates admitted at University of Gondar comprehensive specialized hospital neonatal intensive care unit, Northwest Ethiopia

Prematurity accounts about 1 million neonatal deaths worldwide and the second causes of both neonatal and under five-child mortality. Neonatal mortality accounts for 43% of under-five child mortality in Ethiop...

Authors: Ayenew Engida Yismaw, Abebaw Addis Gelagay and Malede Mequanent Sisay

Hepatomegaly and type 1 diabetes: a clinical case of Mauriac’s syndrome

Hepatic glycogenosis is characterized by excessive glycogen accumulation in hepatocytes and represents a complication of poor controlled type 1 diabetes. It can be caused by excessive insulin doses or recurren...

Authors: Fortunato Lombardo, Stefano Passanisi, Albino Gasbarro, Giovanni Tuccari, Antonio Ieni and Giuseppina Salzano

A modified physiologic test for bronchopulmonary dysplasia: a clinical tool for weaning from CPAP and/or oxygen-therapy the premature babies?

A physiologic test for estimating BPD rate has been developed by Walsh and collaborators. Actually there are not standard criteria for weaning from CPAP and/or oxygen therapy the premature babies. Aim of this ...

Authors: Giovanni Vento, Valentina Vendettuoli, Claudia Aurilia, Milena Tana, Chiara Tirone, Alessandra Lio, Piero Giuseppe Matassa, Francesca Priolo, Piero Catenazzi, Mirta Corsello, Enrico Zecca and Fabio Mosca

Postnatal length and weight growth velocities according to Fenton reference and their associated perinatal factors in healthy late preterm infants during birth to term-corrected age: an observational study

Optimum early postnatal growth is critical for early and later health of preterm infants. Postnatal length and weight growth velocities and their associated perinatal factors in healthy late preterm infants wi...

Authors: Li Zhang, Yan Li, Shuang Liang, Xiao-Juan Liu, Feng-Ling Kang and Gui-Mei Li

Listeria monocytogenes meningitis in immunocompetent and healthy children: a case report and a review of the literature

Listeria monocytogenes is a gram-positive bacteria generally transmitted to humans through ingestion of contaminated food. It typically infects high risk subjects, such as pregnant women, neonates, the elderly an...

Authors: Massimo Luca Castellazzi, Paola Marchisio and Samantha Bosis

Is preterm birth associated with asthma among children from birth to 17 years old? -A study based on 2011-2012 US National Survey of Children’s Health

Preterm birth can interrupt lung development in utero and is associated with early life factors, which adversely affects the developing respiratory system. Studies on preterm birth and asthma risk are comparat...

Authors: Jie Zhang, Chenchao Ma, Aimin Yang, Rongqiang Zhang, Jiannan Gong and Fengfeng Mo

74th Congress of the Italian Society of Pediatrics

Authors:

Evaluation of serum 25-Hydroxy vitamin D levels in children with autism Spectrum disorder

Vitamin D plays an important role in etiology of Autism Spectrum Disorders (ASDs). We aimed to evaluate the serum 25 - hydroxyl vitamin D level among children with ASDs in Ahvaz city, Iran.

Authors: Ali Asghar Arastoo, Hesam Khojastehkia, Zahra Rahimi, Morteza Abdullatif Khafaie, Syed Ahmad Hosseini, Mohammad Taghi Mansouri, Shabnam Yosefyshad, Maryam Abshirini, Noshin Karimimalekabadi and Maria Cheraghi

Re-comparing of three different epidemic seasons of bronchiolitis: different prophylaxis approaches

During the last epidemic season of bronchiolitis (S2, years 2016–2017) we performed a single Centre analysis in inborn infant of 30^+ 0–32^+ 6 gestational age and age < 12 months who did not receive prophylaxis wit...

Authors: Simonetta Picone, Adele Fabiano, Davide Roma, Federico Di Palma and Piermichele Paolillo

SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children

Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children ...

Authors: Carlo Caffarelli, Fabrizio Franceschini, Davide Caimmi, Francesca Mori, Lucia Diaferio, Dora Di Mauro, Carla Mastrorilli, Stefania Arasi, Simona Barni, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Pasquale Comberiati, Giuseppe Crisafulli, Lucia Liotti, Umberto Pelosi…

Gambling disorder in adolescents: what do we know about this social problem and its consequences?

Gambling disorder (GD) is a psychiatric condition and it is characterized by a maladaptive pattern of gambling behavior that persists despite negative consequences in major areas of life functioning. In Italy,...

Authors: Pietro Ferrara, Giulia Franceschini and Giovanni Corsello

Genomics of neonatal sepsis: has-miR-150 targeting BCL11B functions in disease progression

Neonatal sepsis is an inflammatory systemic syndrome, which is a major cause of morbidity and mortality in premature infants. We analyzed the expression profile data of E-MTAB-4785 to reveal the pathogenesis o...

Authors: Li Huang, Lixing Qiao, Huan Zhu, Li Jiang and Liping Yin

Off-label drugs use in pediatric palliative care

Paediatric palliative care (PPC) aim to ensure the control of symptoms and the best possible quality of life for patients whose underlying disease, characterized by an unstoppable evolution and negative progno...

Authors: Lucia De Zen, Federico Marchetti, Egidio Barbi and Franca Benini

Anaphylactic shock with methylprednisolone, Kounis syndrome and hypersensitivity to corticosteroids: a clinical paradox

Corticosteroids are widely used for the treatment of allergic reactions but paradoxically themselves may induce acute, delayed, local or systemic allergic reactions and even anaphylaxis with Kounis syndrome. T...

Authors: Nicholas G. Kounis, Ioanna Koniari, George D. Soufras and Emmanouil Chourdakis

Perception of childhood anaemia among mothers in Kumasi: a quantitative approach

Anaemia is the world’s second cause of disability and it affects over half of pre-school children in developing countries and at least 30–40% in industrial countries. In poorer malaria-endemic countries, anemi...

Authors: Reindolf Anokye, Enoch Acheampong, Anthony Kwaku Edusei, Wisdom Kwadwo Mprah, Justice Ofori-Amoah, Vida Maame Kissiwaa Amoah and Vincent Ekow Arkorful

Low birth weight and its associated factors in Ethiopia: a systematic review and meta-analysis

Different primary studies in Ethiopia showed the burden of low birth weight. However, variation among those studies was seen. This study was aimed to estimate the national prevalence and associated factors of ...

Authors: Aklilu Endalamaw, Eshetu Haileselassie Engeda, Daniale Tekelia Ekubagewargies, Getaneh Mulualem Belay and Mekuriaw Alemayehu Tefera

West-Nile virus encephalitis in an immunocompetent pediatric patient: successful recovery

West Nile virus (WNV) is a mosquito-borne RNA virus belonging to the Flaviviridae family. Symptomatic infection happens in only about 20% of the cases, while WNV neuroinvasive disease (WNND) is rare and accounts ...

Authors: Salvatore Savasta, Francesca Rovida, Thomas Foiadelli, Anna Maria Campana, Elena Percivalle, Gian Luigi Marseglia and Fausto Baldanti

Hospital clinical pathways for children affected by juvenile idiopathic arthritis

Juvenile idiopathic arthritis (JIA) is the most common pediatric chronic rheumatic disease, which requires constant follow-up over the years, due to relapses during its progression. To maintain a good quality ...

Authors: L. Cavazzana, M. Fornili, G. Filocamo, C. Agostoni, F. Auxilia and S. Castaldi

An early diagnosis of trichorhinophalangeal syndrome type 1: a case report and a review of literature

Trichorhinophalangeal syndrome (TRPS) is a rare autosomal dominant disorder caused by defects involving the TRPS1 gene. It exhibits distinctive craniofacial, ectodermal and skeletal abnormalities, such as sparse ...

Authors: Giulia Trippella, Paolo Lionetti, Sara Naldini, Francesca Peluso, Matteo Della Monica and Stefano Stagi

Differentiating Kawasaki disease from urinary tract infection in febrile children with pyuria and C-reactive protein elevation

Kawasaki disease (KD) is sometimes confused with urinary tract infection (UTI) because both can present with pyuria and C-reactive protein (CRP) elevation. The present study investigated the clinical and labor...

Authors: Seung Beom Han and Soo-Young Lee

Phenotypic testicular abnormalities and pubertal development in boys with McCune-Albright syndrome

Aim of this survey is to review the few available literature data on pathophysiologic and clinical aspects of pubertal development in boys with McCune-Albright syndrome (MAS). On the basis of such analysis, we...

Authors: Tommaso Aversa, Giuseppina Zirilli, Domenico Corica, Filippo De Luca and Malgorzata Wasniewska

Mucopolysaccharidoses: early diagnostic signs in infants and children

Mucopolysaccharidoses (MPS) comprise a group of lysosomal disorders that are characterized by progressive, systemic clinical manifestations and a coarse phenotype. The different types, having clinical, biochem...

Authors: Cinzia Galimberti, Annalisa Madeo, Maja Di Rocco and Agata Fiumara

Clinical hints to diagnosis of attenuated forms of Mucopolysaccharidoses

The mucopolysaccharidoses (MPS) are clinically similar but also heterogeneous in terms of major or minor involvement of different organs/systems, burden of disease, and rate of progression. The attenuated form...

Authors: Miriam Rigoldi, Elena Verrecchia, Raffaele Manna and Maria Teresa Mascia

Possible strategies to cross the blood–brain barrier

The mucopolysaccharidoses (MPS) are a heterogeneous group of in-born metabolic conditions caused by genetic defects that result in the absence or severe deficiency of one of the lysosomal hydrolases responsibl...

Authors: Cinzia M. Bellettato and Maurizio Scarpa

Gene therapy for mucopolysaccharidoses: in vivo and ex vivo approaches

Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders caused by a deficiency in lysosomal enzymes catalyzing the stepwise degradation of glycosaminoglycans (GAGs). The current therapeutic stra...

Authors: Alessandro Fraldi, Marta Serafini, Nicolina Cristina Sorrentino, Bernhard Gentner, Alessandro Aiuti and Maria Ester Bernardo

Biochemical and molecular analysis in mucopolysaccharidoses: what a paediatrician must know

Mucopolysaccharidoses (MPS) are rare inherited disorders caused by a deficit of the lysosomal hydrolases involved in the degradation of mucopolysaccharides, also known as glycosaminoglycans (GAGs). They are al...

Authors: Mirella Filocamo, Rosella Tomanin, Francesca Bertola and Amelia Morrone

A new case report of severe mucopolysaccharidosis type VII: diagnosis, treatment with haematopoietic cell transplantation and prenatal diagnosis in a second pregnancy

A new patient with severe mucopolysaccharidosis (MPS) type VII is reported. Non-immune hydrops fetalis (NIHF) was diagnosed during pregnancy. At birth, he showed generalized hydrops and dysmorphic features typ...

Authors: Francesca Furlan, Attilio Rovelli, Miriam Rigoldi, Mirella Filocamo, Barbara Tappino, Douglas Friday, Serena Gasperini, Silvana Mariani, Claudia Izzi, Maria Pia Bondioni, Cinzia Gellera, Anna Venerando, Nicoletta Villa, Maria del Carmen Rodriguez Perez, Fabio Pavan, Andrea Biondi…

ENT and mucopolysaccharidoses

The mucopolysaccharidoses (MPS) are a heterogeneous group of inherited metabolic disorders, each associated with a deficiency in one of the enzymes involved in glycosaminoglycan (GAG) catabolism. Over time, GA...

Authors: Pier Marco Bianchi, Renato Gaini and Silvano Vitale

Newborn screening in mucopolysaccharidoses

Newborn screening (NBS) methods and therapeutic options have become increasingly available for mucopolysaccharidoses (MPS), and there is a clear evidence that early intervention significantly improves the outc...

Authors: Maria Alice Donati, Elisabetta Pasquini, Marco Spada, Giulia Polo and Alberto Burlina

Ocular features in mucopolysaccharidosis: diagnosis and treatment

Mucopolysaccharidoses (MPS) are a group of rare lysosomal storage disorders characterized by the accumulation of glycosaminoglycans (GAGs) in different parts of the eye. Ocular problems are very common in MPS ...

Authors: Alessandra Del Longo, Elena Piozzi and Fiammetta Schweizer

New treatments for the mucopolysaccharidoses: from pathophysiology to therapy

Enzyme replacement therapy is currently considered the standard of care for the treatment of mucopolysaccharidoses (MPS) type I, II, VI, and IV. This approach has shown substantial efficacy mainly on somatic s...

Authors: Simona Fecarotta, Serena Gasperini and Giancarlo Parenti

Orthopaedic challenges for mucopolysaccharidoses

Mucopolysaccharidoses (MPS) are a group of diseases characterized by abnormal accumulation of glycosaminoglycans (GAGs). Although there are differences among the various disease types, the osteoarticular syste...

Authors: Andrea Borgo, Andrea Cossio, Denise Gallone, Francesca Vittoria and Marco Carbone

Early diagnosis and management of cardiac manifestations in mucopolysaccharidoses: a practical guide for paediatric and adult cardiologists

Mucopolysaccharidoses (MPS) are a group of hereditary disorders caused by lysosomal storage of glycosaminoglycans (GAGs) and characterized by a wide variability of phenotypes from severe fetal-neonatal forms t...

Authors: Lucia Boffi, Pierluigi Russo and Giuseppe Limongelli

Neurobehavioral phenotypes of neuronopathic mucopolysaccharidoses

Mucopolysaccharidoses (MPS) are a group of lysosomal multisystemic, chronic, and progressive diseases characterized by the storage of glycosaminoglycans (GAGs) that may affect the central nervous system. Neuro...

Authors: Rita Barone, Alessandra Pellico, Annarita Pittalà and Serena Gasperini

Enzyme replacement therapy: efficacy and limitations

Enzyme replacement therapy (ERT) is available for mucopolysaccharidosis (MPS) I, MPS II, MPS VI, and MPS IVA. The efficacy of ERT has been evaluated in clinical trials and in many post-marketing studies with a...

Authors: Daniela Concolino, Federica Deodato and Rossella Parini

Cerebral and occipito-atlanto-axial involvement in mucopolysaccharidosis patients: clinical, radiological, and neurosurgical features

Neurosurgical features of mucopolysaccharidosis (MPS) patients mainly involve the presence of cranio-vertebral junction (CVJ) abnormalities and the development of communicating hydrocephalus. CVJ pathology is ...

Authors: Carlo Giussani, Lelio Guida, Francesco Canonico and Erik P. Sganzerla

The role of imaging in the skeletal involvement of mucopolysaccharidoses

This article discusses the role of imaging modalities including radiography, multi-detector computed tomography, magnetic resonance imaging, and ultrasound in diagnosing and monitoring skeletal abnormalities i...

Authors: Vincenzo Spina, Domenico Barbuti, Alberto Gaeta, Stefano Palmucci, Ernesto Soscia, Marco Grimaldi, Antonio Leone, Renzo Manara and Gabriele Polonara

The new frame for Mucopolysaccharidoses

Mucopolysaccharidoses (MPS) are genetic, progressive, lysosomal storage disorders affecting virtually all organs and systems. The first MPS were clinically identified about 100 years ago. Nowadays, the enzyme ...

Authors: Rossella Parini and Andrea Biondi

Anesthesiological risks in mucopolysaccharidoses

Patients suffering from mucopolysaccharidosis are among the most complex from the anesthesiological point of view, especially regarding the management of the airway. The evidence base for anesthesia management...

Authors: Alessandra Moretto, Maria Grazia Bosatra, Laura Marchesini and Simonetta Tesoro

Anaphylaxis in atypical cold urticaria: case report and review of literature

Cold-induced urticaria is a kind of physical urticaria characterized by the appearance of wheals after exposure to cold. The atypical form is a rare sub-type characterized by appearance of hives even in areas ...

Authors: Elisa Benelli, Giorgio Longo, Egidio Barbi and Irene Berti

Determinants of breastfeeding discontinuation in an Italian cohort of mother-infant dyads in the first six months of life: a randomized controlled trial

Among breastfeeding determinants, the marketing of breast milk substitutes might contribute to suboptimal breastfeeding rates. The aim of this study was to investigate the effect of receiving information on br...

Authors: Fabio Mosca, Paola Roggero, Francesca Garbarino, Daniela Morniroli, Beatrice Bracco, Laura Morlacchi, Domenica Mallardi, Maria Lorella Gianni and Dario Consonni