Articles

Neonatal mortality in the case of Felege Hiwot referral hospital, Bahir Dar, Amhara Regional State, North West Ethiopia 2016: a one year retrospective chart review

Ethiopia is among the countries with the highest neonatal mortality with the rate of 37 deaths per 1000 live births. In spite of many efforts by the government and other partners, non significant decline has b...

Authors: Tilahun Tewabe, Yenatfanta Mehariw, Eyerusalem Negatie and Bertukan Yibeltal

Prevalence of electrolyte disturbances in perinatal asphyxia: a prospective study

Birth asphyxia is defined as the presence of hypoxia, hypercapnia, and acidosis leading the newborn to systemic disturbances probably electrolyte disturbance also. Knowledge of these electrolyte disturbances i...

Authors: Jitendra Thakur, Nisha Keshary Bhatta, Rupa Rajbhandari Singh, Prakash Poudel, Madhab Lamsal and Anjum Shakya

Inhaled nitric oxide as a rescue therapy in a preterm neonate with severe pulmonary hypertension: a case report

Inhaled nitric oxide (iNO) has been approved for the treatment of persistent pulmonary hypertension of the newborn (PPHN) in term and near-term newborns. Its role in the management of persistent pulmonary hype...

Authors: Martina Busè, Francesco Graziano, Fabio Lunetta, Giorgio Sulliotti and Vincenzo Duca

Benign and severe early-life seizures: a round in the first year of life

At the onset, differentiation between abnormal non-epileptic movements, and epileptic seizures presenting in early life is difficult as is clinical diagnosis and prognostic evaluation of the various seizure di...

Authors: Piero Pavone, Giovanni Corsello, Martino Ruggieri, Silvia Marino, Simona Marino and Raffaele Falsaperla

Does a low FODMAPs diet reduce symptoms of functional abdominal pain disorders? A systematic review in adult and paediatric population, on behalf of Italian Society of Pediatrics

Despite the rising of the Functional Gastrointestinal Disorders (FGIDs)’ incidence in the last years, the etio-pathogenesis of FGIDs remains unclear. The diet seems to play an important role in these disorders...

Authors: Rossella Turco, Silvia Salvatore, Erasmo Miele, Claudio Romano, Gian Luigi Marseglia and Annamaria Staiano

Metabolic acidosis as Food Protein Induced Enterocolitis Syndrome (FPIES) onset in a newborn

FPIES (Food Protein Induced Eneterolitis Syndrome) is a rare non IgE- mediated food allergy, usually affecting infants and children after first months of life. Clinical presentation is heterogeneous, usually c...

Authors: Antonella Peduto, Mario Rocca, Cinzia De Maio, Federica Gallarotti, Giulia Pomero and Paolo Gancia

Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians

Vitamin D plays a pivotal role in the regulation of calcium-phosphorus metabolism, particularly during pediatric age when nutritional rickets and impaired bone mass acquisition may occur.

Authors: Giuseppe Saggese, Francesco Vierucci, Flavia Prodam, Fabio Cardinale, Irene Cetin, Elena Chiappini, Gian Luigi de’ Angelis, Maddalena Massari, Emanuele Miraglia Del Giudice, Michele Miraglia Del Giudice, Diego Peroni, Luigi Terracciano, Rino Agostiniani, Domenico Careddu, Daniele Giovanni Ghiglioni, Gianni Bona…

Human respiratory syncytial virus and hospitalization in young children in Italy

Human respiratory syncytial virus (hRSV) is ubiquitous and causes respiratory diseases in both children and adults. Worldwide, hRSV pneumonia is the second cause of postnatal infant death after malaria. Given ...

Authors: Parvanè Kuhdari, Federica Brosio, Cristina Malaventura, Armando Stefanati, Andrea Orsi, Giancarlo Icardi and Giovanni Gabutti

Baby-led weaning: what a systematic review of the literature adds on

The term weaning describes the time period in which a progressive reduction of breastfeeding or the feeding of infant-formula takes place while the infant is gradually introduced to solid foods. It is a crucia...

Authors: Enza D’Auria, Marcello Bergamini, Annamaria Staiano, Giuseppe Banderali, Erica Pendezza, Francesca Penagini, Gian Vincenzo Zuccotti and Diego Giampietro Peroni

Improved dietary diversity of school adolescent girls in the context of urban Northwest Ethiopia: 2017

Undiversified diet increases the vulnerability of adolescents for different nutritional problems. Therefore, this study assessed dietary and associated factors among school adolescent girls in Gondar city, nor...

Authors: Samuel Mersha Birru, Amare Tariku and Aysheshim Kassahun Belew

Congenital hypopituitarism: how to select the patients for genetic analyses

Aim of this commentary is to analyze the relationships between genotypic bases and phenotypic expression of congenital “multiple pituitary hormone deficiency” (MPHD) syndrome and to indicate some reliable crit...

Authors: Giuseppe Crisafulli, Tommaso Aversa, Giuseppina Zirilli, Filippo De Luca, Romina Gallizzi and Malgorzata Wasniewska

Guideline on management of the acute asthma attack in children by Italian Society of Pediatrics

Acute asthma attack is a frequent condition in children. It is one of the most common reasons for emergency department (ED) visit and hospitalization. Appropriate care is fundamental, considering both the high...

Authors: Luciana Indinnimeo, Elena Chiappini and Michele Miraglia del Giudice

Clinical and molecular characterization of 112 single-center patients with Neurofibromatosis type 1

The aim of this retrospective study was to define clinical and molecular characteristics of a large sample of neurofibromatosis type 1 (NF1) patients, as well as to evaluate mutational spectrum and genotype-ph...

Authors: Giovanni Corsello, Vincenzo Antona, Gregorio Serra, Federico Zara, Clara Giambrone, Luca Lagalla, Maria Piccione and Ettore Piro

Clinical characteristics of headache in Italian adolescents aged 11–16 years: a cross-sectional questionnaire school-based study

The purpose of this study was to determine headache characteristics, impact on daily activities and medication attitudes among a large sample of adolescents in Italy.

Authors: Thomas Foiadelli, Alessandra Piccorossi, Lucia Sacchi, Mara De Amici, Maurizio Tucci, Ilaria Brambilla, Gian Luigi Marseglia, Salvatore Savasta and Alberto Verrotti

A Klinefelter boy with congenital adrenal hyperplasia: too much or too little androgens?

The simultaneous occurrence of Klinefelter Syndrome (KS) and Congenital Adrenal Hyperplasia (CAH) is an exceptional event: there are just three case reports (two children and a 51 years old man) describing mal...

Authors: Giada Zanella, Gianluca Tornese, Elisabetta Mascheroni, Elena Faleschini, Alessandro Ventura and Egidio Barbi

Pleural effusion from intrathoracic migration of a ventriculo-peritoneal shunt catheter: pediatric case report and review of the literature

Pleural effusion is a rare complication of ventriculo-peritoneal (VP) cerebrospinal fluid (CSF) shunting and its diagnosis is difficult in patients with neurological and consciousness impairment.

Authors: Federica Porcaro, Emidio Procaccini, Maria Giovanna Paglietti, Alessandra Schiavino, Francesca Petreschi and Renato Cutrera

Seizures in children with neurofibromatosis type 1: is neurofibromatosis type 1 enough?

Neurofibromatosis type 1 (NF1) is related to a generally increased prevalence of seizures. The mechanism underlying the increased predisposition to seizures has not been fully elucidated. The aim of the study ...

Authors: Claudia Santoro, Pia Bernardo, Antonietta Coppola, Umberto Pugliese, Mario Cirillo, Teresa Giugliano, Giulio Piluso, Giuseppe Cinalli, Salvatore Striano, Carmela Bravaccio and Silverio Perrotta

Vitamin D levels and parathyroid hormone variations of children living in a subtropical climate: a data mining study

Vitamin D and intact parathyroid hormone (iPTH) play a crucial role in calcium homeostasis and bone health of children. Serum level of 25-hydroxyvitamin D (25-OHD) is considered to be the most accurate marker ...

Authors: Ozlem Naciye Sahin, Muhittin Serdar, Mustafa Serteser, Ibrahim Unsal and Aysel Ozpinar

Epidemiological and clinical aspects of autoimmune thyroid diseases in children with Down’s syndrome

Aim of this commentary is to report the main peculiarities that have been found to characterize the phenotypic expression of autoimmune thyroid diseases (AITDs) in children with Down’s syndrome (DS). According...

Authors: Tommaso Aversa, Giuseppe Crisafulli, Giuseppina Zirilli, Filippo De Luca, Romina Gallizzi and Mariella Valenzise

The relationship between body mass index and children’s presentations to a tertiary pediatric emergency department

The child obesity and its complications are associated with an alarming increased health care use, including the emergency department (ED). We evaluated the effects of the obesity and overweight in children ad...

Authors: Valentina Ferro, Antonella Mosca, Francesca Crea, Maria Alessia Mesturino, Carla Olita, Andrea Vania, Antonino Reale, Valerio Nobili and Umberto Raucci

Dolutegravir-based anti-retroviral therapy is effective and safe in HIV–infected paediatric patients

Treatment of HIV infection in adolescents is challenging due to long duration of therapy and poor adherence. Recently, the integrase strand transfer inhibitor dolutegravir (DTG) has been approved for the use i...

Authors: Eugenia Bruzzese, Andrea Lo Vecchio, Andrea Smarrazzo, Orsola Tambaro, Giulia Palmiero, Giovanni Bonadies and Alfredo Guarino

Vitamin K deficiency: a case report and review of current guidelines

Vitamin K, a fat soluble vitamin, is a necessary cofactor for the activation of coagulation factors II, VII, IX, X, and protein C and S. In neonatal period, vitamin K deficiency may lead to Vitamin K Deficienc...

Authors: Maria Rosaria Marchili, Elisa Santoro, Alessandra Marchesi, Simona Bianchi, Lelia Rotondi Aufiero and Alberto Villani

Guidelines on pediatric day surgery of the Italian Societies of Pediatric Surgery (SICP) and Pediatric Anesthesiology (SARNePI)

The Italian Society of Pediatric Surgery (SICP) together with The Italian Society of Pediatric Anesthesia (SARNePI) through a systematic analysis of the scientific literature, followed by a consensus conferenc...

Authors: Ugo de Luca, Giovanni Mangia, Simonetta Tesoro, Ascanio Martino, Maria Sammartino and Alessandro Calisti

Prematurity, ventricular septal defect and dysmorphisms are independent predictors of pathogenic copy number variants: a retrospective study on array-CGH results and phenotypical features of 293 children with neurodevelopmental disorders and/or multiple congenital anomalies

Since 2010, array-CGH (aCGH) has been the first-tier test in the diagnostic approach of children with neurodevelopmental disorders (NDD) or multiple congenital anomalies (MCA) of unknown origin. Its broad appl...

Authors: I. Maini, I. Ivanovski, O. Djuric, S. G. Caraffi, E. Errichiello, M. Marinelli, F. Franchi, V. Bizzarri, S. Rosato, M. Pollazzon, C. Gelmini, M. Malacarne, C. Fusco, G. Gargano, S. Bernasconi, O. Zuffardi…

A comparison of efficacy of six prediction models for intravenous immunoglobulin resistance in Kawasaki disease

Kawasaki disease (KD) is the most common pediatric vasculitis. Several models have been established to predict intravenous immunoglobulin (IVIG) resistance. The present study was aimed to evaluate the efficacy...

Authors: Weiguo Qian, Yunjia Tang, Wenhua Yan, Ling Sun and Haitao Lv

One in three adolescent schoolgirls in urban northwest Ethiopia is stunted

Poor nutritional status of adolescent girls has a negative effect on the next generation as undernourished adolescents enter pregnancy with poor nutrient reserve. However, there is scarcity of evidence showing...

Authors: Samuel Mersha Birru, Aysheshim Kassahun Belew and Amare Tariku

What family doctors know about congenital CMV: a regional survey in Iran

Since there is no effective treatment or vaccine against the congenital cytomegalovirus (cCMV) infection, knowledge and awareness of medical doctor’s (MDs) especially family doctors are essential for preventiv...

Authors: Ahmad Hosseinzadeh Adli, Chiman Karami, Sanaz Baghban Rahimi, Azam Mirarab and Alijan Tabarraei

Detection of IL10-producing B cell (B10) in adenoids of atopic children with adenoidal hypertrophy

Authors: Chiara Valsecchi, Sara Carlotta Tagliacarne, Ilaria Brambilla, Catherine Klersy, Marco Benazzo, Lorenza Montagna, Dimitri Poddighe, Giorgio Ciprandi, Gian Luigi Marseglia, Amelia Licari and Annamaria Castellazzi

Effects of undernutrition on survival of human immunodeficiency virus positive children on antiretroviral therapy

The relationship between undernutrition and HIV is bidirectional, ultimately contributing to quality of life and survival of affected individuals. Ethiopia is a sub-Saharan nation influenced by both undernutri...

Authors: Animut Alebel, Fasil Wagnew, Cheru Tesema, Getiye Dejenu Kibret, Pammla Petrucka and Setegn Eshite

Salmonella osteomyelitis in a previously healthy neonate: a case report and review of the literature

Acute osteomyelitis, which is uncommon in neonates, needs to be quickly diagnosed and treated to avoid devastating sequelae. Therefore, it is important to maintain a high index of suspicion and be aware of the...

Authors: Canyang Zhan, Jing Du and Lihua Chen

Neonatal diagnosis of isolated absence of the right pulmonary artery: a case report and review of the literature

Unilateral absence of the pulmonary artery (UAPA) is a rare congenital malformation often associated with other cardiac anomalies; however it may occur as an isolated lesion. Isolated absence of the right pulm...

Authors: Akamin Raymond, Ettore Pedretti, Giuseppina Privitera, Cristina Cicero and Giacomo Biasucci

Chronic recurrent multifocal osteomyelitis: a case report

Chronic recurrent multifocal osteomyelitis (CRMO), also known as chronic nonbacterial osteomyelitis, is a rare, noninfectious inflammatory disorder that causes multifocal bone lesions with swelling and pain. L...

Authors: Maria Francesca Gicchino, Mario Diplomatico, Carmela Granato, Daniela Capalbo, Pierluigi Marzuillo, Alma Nunzia Olivieri and Emanuele Miraglia del Giudice

Subclinical hypothyroidism in children: is it always subclinical?

Aim of this commentary is to report current knowledges on the main clinical and metabolic abnormalities which might be observed in children with longstanding and untreated subclinical hypothyroidism (SH) and t...

Authors: R. Gallizzi, C. Crisafulli, T. Aversa, G. Salzano, F. De Luca, M. Valenzise and G. Zirilli

The predictive role of pelvic magnetic resonance in the follow up of spontaneous or induced puberty in turner syndrome

Puberty is a critical age for patients with Turner syndrome (TS): infertility is reported to be linked to karyotype and spontaneous puberty and menarche occur in approximately 30% of patients, especially in mo...

Authors: M. C. Maggio, A. De Pietro, P. Porcelli, F. Serraino, T. Angileri, A. Di Peri and G. Corsello

Low Dose Medicine: theoretical background and scientific evidence

Authors: S. Bernasconi

Thyroid function test evolution in children with Hashimoto’s thyroiditis is closely conditioned by the biochemical picture at diagnosis

Aim of this commentary is to summarize the salient literature views on the relationships between presentation and evolution patterns of thyroid function in children with Hashimoto’s thyroiditis (HT).

Authors: Giuseppe Crisafulli, Romina Gallizzi, Tommaso Aversa, Giuseppina Salzano, Mariella Valenzise, Malgorzata Wasniewska, Filippo De Luca and Giuseppina Zirilli

Acute malnutrition among children aged 6–59 months of the nomadic population in Hadaleala district, Afar region, northeast Ethiopia

Acute malnutrition to be a major health burden in the world, particularly in the developing world. Acute malnutrition is associated with more than one third of the global disease burden for children. Malnouris...

Authors: Zemichael Gizaw, Wondwoson Woldu and Bikes Destaw Bitew

Teaching pain recognition through art: the Ramsay-Caravaggio sedation scale

Clinical observation is a key component of medical ability, enabling immediate evaluation of the patient’s emotional state and contributing to a clinical clue that leads to final decision making. In medical sc...

Authors: Federico Poropat, Giorgio Cozzi, Andrea Magnolato, Lorenzo Monasta, Fabio Borrometi, Baruch Krauss, Alessandro Ventura and Egidio Barbi

Etiological heterogeneity and clinical variability in newborns with esophageal atresia

The aim of this study was to define different characteristics of infants with esophageal atresia and correlations with neonatal level of care, morbidity and mortality occurring during hospital stay.

Authors: Ettore Piro, Ingrid Anne Mandy Schierz, Mario Giuffrè, Giovanni Cuffaro, Simona La Placa, Vincenzo Antona, Federico Matina, Giuseppe Puccio, Marcello Cimador and Giovanni Corsello

Food triggers and inherited metabolic disorders: a challenge to the pediatrician

Several disorders should be considered in the case of newborns and infants experiencing acute or recurrent symptoms after food ingestion. Immune-mediated adverse food reactions are the most frequent and always...

Authors: Evelina Maines, Annunziata Di Palma and Alberto Burlina

Overweight/obesity among school aged children in Bahir Dar City: cross sectional study

Developing countries, including Ethiopia are experiencing a double burden of malnutrition. There is limited information about prevalence of overweight/obesity among school aged children in Ethiopia particularl...

Authors: Teferi Mekonnen, Amare Tariku and Solomon Mekonnen Abebe

School feeding program has resulted in improved dietary diversity, nutritional status and class attendance of school children

School Feeding Program (SFP) is a targeted safety net program designed to provide educational and health benefits to vulnerable children. However, limited evidence exists regarding the effect of the interventi...

Authors: Mastewal Zenebe, Samson Gebremedhin, Carol J. Henry and Nigatu Regassa

Serum vitamin D and vitamin D-binding protein levels in mother-neonate pairs during the lactation period

To determine longitudinally the relationship between serum 25-hydroxyvitamin D (vitamin D) and vitamin D-binding protein (DBP) levels in mother-neonate pairs and evaluate the efficiency of prophylactic vitamin...

Authors: Hakan Doneray, Remziye Seda Yesilcibik, Esra Laloglu, Metin Ingec and Zerrin Orbak

Cyberbullying a modern form of bullying: let’s talk about this health and social problem

Cyberbullying or electronic aggression has already been designated as a serious public health threat. Cyberbullying should also be considered as a cause for new onset psychological symptoms, somatic symptoms o...

Authors: Pietro Ferrara, Francesca Ianniello, Alberto Villani and Giovanni Corsello

Differentiated thyroid carcinoma presentation may be more aggressive in children and adolescents than in young adults

The available studies concerning the influence of age on the phenotypical expression of differentiated thyroid carcinoma (DTC) have hitherto compared DTC presentation either between pre-pubertal and pubertal c...

Authors: Giuseppina Zirilli, Laura Cannavò, Francesco Vermiglio, Maria Antonia Violi, Filippo De Luca and Malgorzata Wasniewska

Atypical phenotypic aspects of autoimmune thyroid disorders in young patients with Turner syndrome

Aim of this commentary is to analyze the current views about the phenotypic features of Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) in Turner syndrome (TS) girls, in terms of epidemiology, clinical a...

Authors: Tommaso Aversa, Romina Gallizzi, Giuseppina Salzano, Giuseppina Zirilli, Filippo De Luca and Mariella Valenzise

Comparing of two different epidemic seasons of bronchiolitis

Acute bronchiolitis is the most common cause of hospitalizations in infants < 12 months of age and preventive efforts remain the most important strategy to date. Recently prophylaxis with palivizumab (PLV) was...

Authors: Simonetta Picone, Adele Fabiano, Davide Roma and Piermichele Paolillo

Children with premature pubarche: is an alterated neonatal 17-Ohp screening test a predictive factor?

Neonatal screening for 21 hydroxylase deficiency is designed to detect classical form of congenital adrenal hyperplasia (CAH). It is still unclear whether newborns who result false positives at neonatal screen...

Authors: Paolo Cavarzere, Margherita Mauro, Monica Vincenzi, Silvana Lauriola, Francesca Teofoli, Rossella Gaudino, Diego Alberto Ramaroli, Rocco Micciolo, Marta Camilot and Franco Antoniazzi

Abstracts from the 23rd Italian congress of Cystic Fibrosis and the 13th National congress of Cystic Fibrosis Italian Society

Authors: Annamaria Bevivino, Alessandra Coiana, Annalisa Fogazzi, Fabiana Timelli, Sandra Signorini, Marco Lucarelli, Patrizia Morelli, Rita Padoan, Barbara Giordani, Annalisa Amato, Fabio Majo, Gianluca Ferrari, Serena Quattrucci, Laura Minicucci, Giovanna Floridia, Gianna Puppo Fornaro…

Early neonatal Glutaric aciduria type I hidden by perinatal asphyxia: a case report

Perinatal asphyxia (PA) occurs in about 2 to 10 per 1000 live full-term births. Although neonatal epileptic seizures are observed in up to 60% of cases, PA may mimic or subtend other conditions. Hypoxia relate...

Authors: Giacomo Biasucci, Nicola Morelli, Federica Natacci and Massimo Mastrangelo