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  1. Association between persistency of a patent ductus arteriosus (PDA) and morbidity in preterm newborns is still controversial. We aimed to investigate the relation between PDA and morbidity in a large retrospec...

    Authors: Gianluca Terrin, Maria Di Chiara, Giovanni Boscarino, Valentina Metrangolo, Francesca Faccioli, Elisa Onestà, Antonella Giancotti, Violante Di Donato, Viviana Cardilli and Mario De Curtis

    Citation: Italian Journal of Pediatrics 2021 47:9

    Content type: Research

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  2. The literature agrees on the impact of post-traumatic stress symptoms in parents of seriously ill children but there is less clarity about the real extent and gender differences of this psychopathological risk...

    Authors: Martina Corsi, Alessandro Orsini, Virginia Pedrinelli, Andrea Santangelo, Carlo Antonio Bertelloni, Niccolò Carli, Rodolfo Buselli, Diego Peroni, Pasquale Striano, Liliana Dell’Osso and Claudia Carmassi

    Citation: Italian Journal of Pediatrics 2021 47:8

    Content type: Review

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  3. Neonatal thrombocytopenia (NT) (platelet count < 150 × 109/L) is a common finding in the neonatal intensive care unit (NICU). The main aim of this study was to assess the prevalence, risk factors, and outcomes of...

    Authors: Amira M. Saber, Shereen P. Aziz, Al Zahraa E. Almasry and Ramadan A. Mahmoud

    Citation: Italian Journal of Pediatrics 2021 47:7

    Content type: Research

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  4. Although several studies have tried to evaluate the real efficacy of school closure for pandemic control over time, no definitive answer to this question has been given. Moreover, it has not been clarified whe...

    Authors: Susanna Esposito, Nicola Cotugno and Nicola Principi

    Citation: Italian Journal of Pediatrics 2021 47:6

    Content type: Debate

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  5. Prokineticin receptor 2 (PROKR2) loss of function mutations have been described as cause of hypogonadotropic hypogonadism. In 2017, a first case of central precocious puberty (CPP) caused by PROKR2 heterozygous g...

    Authors: Francesca Aiello, Grazia Cirillo, Alessandra Cassio, Raffaella Di Mase, Gianluca Tornese, Giuseppina R. Umano, Emanuele Miraglia del Giudice and Anna Grandone

    Citation: Italian Journal of Pediatrics 2021 47:5

    Content type: Research

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  6. Pediatric palliative care (PPC) addresses the physical and psychological needs of children suffering from life-limiting diseases. To define prevention and educational plans and to properly allocate resources, ...

    Authors: Franca Benini, Mariadonata Bellentani, Laura Reali, Pierina Lazzarin, Lucia De Zen, Federico Pellegatta, Pierangelo Lora Aprile and Gianlorenzo Scaccabarozzi

    Citation: Italian Journal of Pediatrics 2021 47:4

    Content type: Letter to the Editor

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  7. This study aimed to compare the clinical features and laboratory tests of infectious mononucleosis (IM) and hemophagocytic syndrome (HLH) caused by Epstein-Barr virus (EBV) in 1–3-year-old children and to expl...

    Authors: Jinjin Shi, Chu Chu, Min Yu, Dandan Zhang, Yuqin Li, Yujie Fan, Yixue Yu, Yali Luo and Weifang Zhou

    Citation: Italian Journal of Pediatrics 2021 47:3

    Content type: Research

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  8. Cystic fibrosis (CF) is a life-threatening disease affecting about 1:3000 newborns in Caucasian populations. The introduction of newborn screening for cystic fibrosis (CF NBS) has improved the clinical outcome...

    Authors: Matteo Botti, Vito Terlizzi, Michela Francalanci, Daniela Dolce, Maria Chiara Cavicchi, Anna Silvia Neri, Valeria Galici, Gianfranco Mergni, Lucia Zavataro, Claudia Centrone, Filippo Festini and Giovanni Taccetti

    Citation: Italian Journal of Pediatrics 2021 47:2

    Content type: Research

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  9. Children with medical complexity represent a big challenge for the physicians, their families and the society as well. Although there is no clear definition of this type of patients, they are affected by a chr...

    Authors: Manuela Gallo, Rino Agostiniani, Roberta Pintus and Vassilios Fanos

    Citation: Italian Journal of Pediatrics 2021 47:1

    Content type: Review

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  10. As health care workers (HCWs) who care for children, who usually demonstrate milder symptoms than adults, family paediatricians have an increased risk of exposure to coronavirus. In April 2020, the Sindacato M...

    Authors: Rinaldo Missaglia, Michael Belingheri, Laura Antolini, Monica de’ Angelis, Luca Brivio, Michele Augusto Riva and Simonetta Genovesi

    Citation: Italian Journal of Pediatrics 2020 46:184

    Content type: Letter to the Editor

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  11. Thromboembolism is a life-threatening, limb-threatening or organ-threatening complication that occurs in patients with primary nephrotic syndrome (NS). There are few studies on the spectrum, complications and ...

    Authors: Yan-Li Lv, Na Guan, Jie Ding, Yong Yao, Hui-Jie Xiao, Xu-Hui Zhong, Fang Wang, Xiao-Yu Liu, Hong-Wen Zhang, Bai-Ge Su and Ke Xu

    Citation: Italian Journal of Pediatrics 2020 46:182

    Content type: Research

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  12. A practical guidance on the management of children with COVID-19 to insure homogeneous criteria for referral to a higher-level facility, according to the disease severity, is pivotal in the pandemic era. A pan...

    Authors: Carlotta Montagnani, Elisabetta Venturini, Manuela L’Erario, Chiara Tersigni, Barbara Bortone, Leila Bianchi, Francesca Menegazzo, Giuseppe Indolfi, Elena Chiappini and Luisa Galli

    Citation: Italian Journal of Pediatrics 2020 46:181

    Content type: Letter to the Editor

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  13. Lately, one of the major clinical and public health issues has been represented by Coronavirus disease of 2019 (COVID-19) during pregnancy and the risk of transmission of the infection from mother to child. De...

    Authors: Nicole Olivini, Francesca Ippolita Calò Carducci, Veronica Santilli, Maria Antonietta De Ioris, Alessia Scarselli, Dario Alario, Caterina Geremia, Mary Haywood Lombardi, Caterina Marabotto, Rosanna Mariani, Raffaele Edo Papa, Emanuela Peschiaroli, Raffaella Scrocca, Serena Sinibaldi, Andrea Smarrazzo, Pietro Stella…

    Citation: Italian Journal of Pediatrics 2020 46:180

    Content type: Research

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  14. Iatrogenic severe hyperglycemia (ISH) caused by glucose-containing i.v. solution is a potentially fatal treatment error. The objective of this study was to investigate the causes, circumstances, course of dise...

    Authors: Nora Bruns, Anja Große Lordemann, Tobias Rasche, Jochen Meyburg, Marcus Krüger, Christian Wieg, Alexander Gratopp, Marc Hoppenz, Friedhelm Heitmann, Thomas Hoppen, Günther Löffler, Ursula Felderhoff-Müser and Christian Dohna-Schwake

    Citation: Italian Journal of Pediatrics 2020 46:179

    Content type: Research

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  15. Stickler syndrome is a connective tissue disorder with predominantly autosomal dominant inheritance, with ocular, auditory and joint involvement.

    Authors: Roberta Onesimo, Cristina De Rose, Clelia Cipolla, Silvia Della Casa, Chiara Leoni, Annabella Salerni, Daniela Ricci and Giuseppe Zampino

    Citation: Italian Journal of Pediatrics 2020 46:178

    Content type: Case report

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  16. Skilled health professional assisted delivery is an effective strategy to reduce maternal and newborn mortality. Skilled assistant delivery can prevent about 16–33% of maternal and newborn mortality. Despite t...

    Authors: Zemenu Tadesse Tessema and Getayeneh Antehunegn Tesema

    Citation: Italian Journal of Pediatrics 2020 46:177

    Content type: Research

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  17. This paper runs through key progresses in epidemiology, pathomechanisms and therapy of various diseases in children that were issued in the Italian Journal of Pediatrics at the end of last year. Novel research...

    Authors: Carlo Caffarelli, Francesca Santamaria, Angelica Santoro, Michela Procaccianti, Fabio Castellano, Francesca Fiori Nastro, Alberto Villani, Sergio Bernasconi and Giovanni Corsello

    Citation: Italian Journal of Pediatrics 2020 46:176

    Content type: Review

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  18. Globally, over 65% of maternal deaths occur during the first 42 days of postpartum while the same proportion of neonatal deaths occur during the first 7 days of life. In sab- Saharan Africa, 4.7 million mother...

    Authors: Zemenu Tadesse Tessema, Lake Yazachew, Getayeneh Antehunegn Tesema and Achamyeleh Birhanu Teshale

    Citation: Italian Journal of Pediatrics 2020 46:175

    Content type: Research

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  19. Even though neonatal mortality reduction is the major goal needed to be achieved by 2030, it is still unacceptably high especially in Ethiopia. In the other hand, low birth weight is the major cause of neonata...

    Authors: Temesgen Getaneh, Ayenew Negesse, Getenet Dessie and Melaku Desta

    Citation: Italian Journal of Pediatrics 2020 46:174

    Content type: Research

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  20. Although children with special health care needs (CSHCN) represent a minority of the population, they go through more hospitalizations, more admissions to the Emergency Department (ED), and receive a major num...

    Authors: Paola Cianci, Valeria D’Apolito, Alex Moretti, Massimo Barbagallo, Sabrina Paci, Maria Teresa Carbone, Riccardo Lubrano, Antonio Urbino, Carlo Dionisi Vici, Luigi Memo, Giuseppe Zampino, Giancarlo La Marca, Alberto Villani, Giovanni Corsello and Angelo Selicorni

    Citation: Italian Journal of Pediatrics 2020 46:173

    Content type: Research

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  21. Lyme neuroborreliosis can cause a variety of neurological manifestations. European children usually present facial nerve palsy, other cranial nerve palsies and aseptic meningitis.

    Authors: Salvatore Savasta, Ivan Fiorito, Thomas Foiadelli, Anna Pichiecchio, Patrizia Cambieri, Bianca Mariani, Piero Marone and Gianluigi Marseglia

    Citation: Italian Journal of Pediatrics 2020 46:172

    Content type: Case report

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  22. In comparison with adults, severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection in children has a milder course. The management of children with suspected or confirmed coronavirus disease (COVI...

    Authors: Francesco Nunziata, Eugenia Bruzzese, Marco Poeta, Luca Pierri, Andrea Catzola, Gian Paolo Ciccarelli, Edoardo Vassallo, Emma Montella, Andrea Lo Vecchio and Alfredo Guarino

    Citation: Italian Journal of Pediatrics 2020 46:170

    Content type: Research

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  23. SAPHO (synovitis, acne, pustolosis, hyperostosis and osteitis) syndrome is a rare autoinflammatory chronic disorder, presenting with non-infectious osteitis, sterile joint inflammation and skin manifestations ...

    Authors: Michele Luzzati, Gabriele Simonini, Cesare Filippeschi, Teresa Giani and Sandra Trapani

    Citation: Italian Journal of Pediatrics 2020 46:169

    Content type: Case report

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  24. Resistance to thyroid hormone syndrome (RTH) is an autosomal dominant or recessive genetic disease caused by mutation of either the thyroid hormone receptorβ (THR-β) gene or the thyroid hormone receptorα (THR-...

    Authors: Hongping Sun, Lin Cao, Rendong Zheng, Shaofeng Xie and Chao Liu

    Citation: Italian Journal of Pediatrics 2020 46:168

    Content type: Review

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  25. Family Accommodation (FA) refers to the involvement of family members (especially parents) in the compulsive behaviors of children and adolescents with Obsessive-Compulsive Disorder (e.g. modifying family rout...

    Authors: Maria Pontillo, Francesco Demaria, Maria Cristina Tata, Roberto Averna, Prisca Gargiullo, Maria Laura Pucciarini, Ornella Santonastaso, Tommaso Boldrini, Alberto Eugenio Tozzi and Stefano Vicari

    Citation: Italian Journal of Pediatrics 2020 46:167

    Content type: Research

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  26. Spinal muscular atrophy (SMA) is an autosomal recessive hereditary disease associated with severe muscle atrophy and weakness in the limbs and trunk. The discovery of mutated genes is helpful in diagnosis and ...

    Authors: Ruiping Zhang, Chunyu Gu, Linjie Pu, Yingtao Meng, Jianbo Shu and Chunquan Cai

    Citation: Italian Journal of Pediatrics 2020 46:166

    Content type: Research

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  27. The timing of puberty in girls is occurring at an increasingly early age. While a positive family history is recognised as a predisposing factor for early or precocious puberty, the role of environmental facto...

    Authors: Stefano Stagi, Salvatore De Masi, Erica Bencini, Stefania Losi, Silvia Paci, Maria Parpagnoli, Franco Ricci, Daniele Ciofi and Chiara Azzari

    Citation: Italian Journal of Pediatrics 2020 46:165

    Content type: Research

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  28. Recurrent diabetic ketoacidosis in patients with known diabetes mellitus remains a relevant problem in pediatrics with an incidence of 1–10% per patient. Children may die because of cerebral edema and had a si...

    Authors: Birtukan Assefa, Haymanot Zeleke, Rajalakshmi Murugan and Kalkidan Wondwossen

    Citation: Italian Journal of Pediatrics 2020 46:164

    Content type: Research

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  29. The phenotypic features of SHOX deficiency (SHOX-D) are highly variable and can be very mild, especially in young children. The aim of this retrospective study was to evaluate auxological and radiological indi...

    Authors: Silvia Vannelli, Maria Baffico, Raffaele Buganza, Francesca Verna, Giulia Vinci, Daniele Tessaris, Gianpaolo Di Rosa, Alberto Borraccino and Luisa de Sanctis

    Citation: Italian Journal of Pediatrics 2020 46:163

    Content type: Research

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  30. Every year, 1.3 million young people reported to die from preventable causes of death. Parent-adolescent communication on sexuality is critical in informing youth about risk and protective behaviors which in t...

    Authors: Maru Mekie, Dagne Addisu, Abenezer Melkie and Wubet Taklual

    Citation: Italian Journal of Pediatrics 2020 46:162

    Content type: Research

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  31. Smith-Lemli-Opitz syndrome (SLOS) is a rare genetic neurodevelopmental disorder caused by the defect in the 7-dehydrocholesterol reductase. This defect leads to the deficiency of cholesterol biosynthesis with ...

    Authors: Maurizio Delvecchio, Biagio Rapone, Simonetta Simonetti, Simona Fecarotta, Graziana De Carlo, Elvira Favoino, Maria Teresa Loverro, Anna Maria Isdraele Romano, Federica Taurino, Edoardo Di Naro and Antonio Gnoni

    Citation: Italian Journal of Pediatrics 2020 46:161

    Content type: Case report

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  32. Group B streptococcus (GBS) is a leading cause of sepsis, pneumonia and meningitis in infants, with long term neurodevelopmental sequelae. GBS may be associated with poor pregnancy outcomes, including spontane...

    Authors: Alberto Berardi, Tiziana Cassetti, Roberta Creti, Caterina Vocale, Simone Ambretti, Mario Sarti, Fabio Facchinetti, Stephen Cose, Paul Heath and Kirsty Le Doare

    Citation: Italian Journal of Pediatrics 2020 46:160

    Content type: Commentary

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  33. In the recent years, clinical progress and better medical assistance for pregnant women, together with the introduction of new complex technologies, has improved the survival of preterm infants. However, this ...

    Authors: Antonella del Vecchio, Sergio Salerno, Massimo Barbagallo, Gaetano Chirico, Mauro Campoleoni, Vittorio Cannatà, Elisabetta Genovese, Claudio Granata, Andrea Magistrelli and Paolo Tomà

    Citation: Italian Journal of Pediatrics 2020 46:159

    Content type: Review

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  34. A number of genetic syndromes associated with variants in the BSCL2/seipin gene have been identified. Variants that cause skipping of exon 7 are associated with progressive encephalopathy with/without lipodystrop...

    Authors: Stefania Pedicelli, Luca de Palma, Caterina Pelosini and Marco Cappa

    Citation: Italian Journal of Pediatrics 2020 46:158

    Content type: Case report

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  35. Thyroid hemangioma mostly occurs in adults and is extremely rare in infants. So far, only four pediatric cases of thyroid hemangioma have been reported, one of which has only been clinically diagnosed. Most of...

    Authors: Yujian Liang, Ronghui Pu, Xueqiong Huang, Suping Li, Yingqian Chen and Wen Tang

    Citation: Italian Journal of Pediatrics 2020 46:157

    Content type: Case report

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  36. The aim of this study was to quantify the impact of coronavirus disease 2019 (COVID-19) on pediatric operations, and establish preoperative, intraoperative, and postoperative protocols to improve the pediatric...

    Authors: Yi Wei, Chengjun Yu, Tian Xin Zhao, Tao Lin, H. E. Dawei, Sheng-de Wu and Guang-hui Wei

    Citation: Italian Journal of Pediatrics 2020 46:155

    Content type: Letter to the Editor

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  37. Autosomal recessive polycystic kidney disease (ARPKD; MIM#263200) is one of the most frequent pediatric renal cystic diseases, with an incidence of 1:20,000. It is caused by mutations of the PKHD1 gene, on chromo...

    Authors: Gregorio Serra, Giovanni Corsello, Vincenzo Antona, Maria Michela D’Alessandro, Nicola Cassata, Marcello Cimador, Mario Giuffrè, Ingrid Anne Mandy Schierz and Ettore Piro

    Citation: Italian Journal of Pediatrics 2020 46:154

    Content type: Case report

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  38. Pediatric COVID-19 is relatively mild and may vary from that in adults. This study was to investigate the epidemic, clinical, and imaging features of pediatric COVID-19 pneumonia for early diagnosis and treatm...

    Authors: Yu Zhang, Ru-Ming Xie, Yu-Lin He, Li-Hong Xing, Li Dong, Jian-Zhong Zhang, Wei-Hong Xing, Xiao-Yan Lv, Yi-Bo Lu, Qiang Liu, Ling-Bo Lin, Gui-Zeng Liu, Li Li, Pan Li, Yuan-Zhong Xie, Zhi-Yu Ni…

    Citation: Italian Journal of Pediatrics 2020 46:153

    Content type: Research

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  39. Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a clinical-radiological syndrome that can be related to infectious and non-infectious conditions. The most prominent neurological sy...

    Authors: Antonella Tuscano, Marisa Zoppo, Carlotta Canavese, Maurizio Cogoni and Carlo Scolfaro

    Citation: Italian Journal of Pediatrics 2020 46:152

    Content type: Case report

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  40. Shwachman-Diamond syndrome (SDS) is a rare genetic, multi-systemic disease characterized by exocrine pancreatic insufficiency, immune deficiency, bone marrow failure and skeletal abnormalities. Most patients p...

    Authors: Agnieszka Bogusz-Wójcik, Honorata Kołodziejczyk, Maja Klaudel-Dreszler, Grzegorz Oracz, Joanna Pawłowska and Mieczysław Szalecki

    Citation: Italian Journal of Pediatrics 2020 46:151

    Content type: Research

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  41. This consensus document has been prepared by a multidisciplinary group of experts (Paediatricians, Radiologists, Paediatric Orthopaedics) and it is mainly aimed at paediatricians, hospitals and primary care pr...

    Authors: Rino Agostiniani, Giuseppe Atti, Salvatore Bonforte, Carolina Casini, Marco Cirillo, Maurizio De Pellegrin, Daniela Di Bello, Francesco Esposito, Ambra Galla, Giorgio Marrè Brunenghi, Nicola Romeo, Paolo Tomà and Norberto Vezzali

    Citation: Italian Journal of Pediatrics 2020 46:150

    Content type: Review

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  42. The rapid spread of the COVID-19 outbreak in Italy has dramatically impacted the National Healthcare System, causing the sudden congestion of hospitals, especially in Northern Italy, thus imposing drastic rest...

    Authors: Giovanni Trisolino, Carlo Enrico Origo, Nando De Sanctis, Daniela Dibello, Pasquale Farsetti, Cosimo Gigante, Pasquale Guida, Lorenza Marengo, Elena Panuccio, Renato Maria Toniolo, Fabio Verdoni and Antonio Memeo

    Citation: Italian Journal of Pediatrics 2020 46:149

    Content type: Commentary

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  43. Pleuropulmonary blastomas (PPB) are rare aggressive paediatric lung malignancies and are among the most common DICER1-related disorders: it is estimated that 75–80% of children with a PPB have the DICER1 mutation...

    Authors: Shihan Zhang, Xisi Wang, Sihui Li, Siyu Cai, Tong Yu, Libing Fu, Na Zhang, Xiaoxia Peng, Qi Zeng and Xiaoli Ma

    Citation: Italian Journal of Pediatrics 2020 46:148

    Content type: Case report

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  44. Bronchiolitis is the primary infection of the lower respiratory tract in children under 2 years of age. Although it is generally considered a single nosological entity, recent studies suggested remarkable clin...

    Authors: Giuliana Ferrante, Carmela Fondacaro, Giovanna Cilluffo, Piera Dones, Francesca Cardella and Giovanni Corsello

    Citation: Italian Journal of Pediatrics 2020 46:147

    Content type: Research

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  45. There is ample evidence that COVID-19 is significantly less severe in children than in adults and asthma and allergy, the most common chronic disorders in children, are not included in the top 10 comorbidities...

    Authors: Lucia Diaferio, Giuseppe Fabio Parisi, Giulia Brindisi, Cristiana Indolfi, Giuseppe Marchese, Daniele Giovanni Ghiglioni, Anna Maria Zicari, Gian Luigi Marseglia and Michele Miraglia del Giudice

    Citation: Italian Journal of Pediatrics 2020 46:146

    Content type: Research

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  46. Food Protein-Induced Enterocolitis Syndrome (FPIES) is a non IgE-mediated food allergy that generally affects children in the first year of life. Usually symptoms break out when formula milk or solid foods are...

    Authors: Francesco Baldo, Martina Bevacqua, Cristiana Corrado, Daniela Nisticò, Laura Cesca, Valentina Declich, Roberto Dall’Amico and Egidio Barbi

    Citation: Italian Journal of Pediatrics 2020 46:144

    Content type: Case report

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  47. The Veneto region is one of the most affected Italian regions by COVID-19. Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), may constitute a risk factor in COVID-19. Moreover, respi...

    Authors: Valentino Bezzerri, Francesca Lucca, Sonia Volpi and Marco Cipolli

    Citation: Italian Journal of Pediatrics 2020 46:143

    Content type: Letter to the Editor

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