Articles

The future outlook on allergen immunotherapy in children: 2018 and beyond

Allergen immunotherapy (AIT) is the only currently available immune-modifying and aetiological treatment for patients suffering from IgE-mediated diseases. In childhood, it represents a suitable therapeutic op...

Authors: Stefania Arasi, Giovanni Corsello, Alberto Villani and Giovanni Battista Pajno

Correction to: The impact of nasal aspiration with an automatic device on upper and lower respiratory symptoms in wheezing children: a pilot case-control study

The original article [1] contained a typesetting error in Table 5; this has now been corrected.

Authors: Antonio Pizzulli, Serena Perna, Anja Bennewiz, Holger Roeblitz, Salvatore Tripodi, Jakob Florack, Petra Wagner, Stephanie Hofmaier and Paolo Maria Matricardi

Egg introduction during complementary feeding according to allergic risk: not just for peanuts!

The relationship between the timing of introduction of complementary foods and later allergy is a topic of current discussion. Although the European Society for Pediatric Gastroenterology Hepatology and Nutrit...

Authors: Elvira Verduci, Annamaria Bianchi, Marta Brambilla and Mauro Calvani

Factors associated with low birthweight in North Shewa zone, Central Ethiopia: case-control study

Low birthweight (LBW) is an important predictor of neonatal and post neonatal child morality. Though its risk factors have been extensively studied in the developed world; limited epidemiological evidence is a...

Authors: Berhanu Gizaw and Samson Gebremedhin

The experience of breastfeeding infants affected by congenital diaphragmatic hernia or esophageal atresia

Newborns with congenital diaphragmatic hernia (CDH) and esophageal atresia (EA) might experience breastfeeding difficulties. The aim of this study was to detect the prevalence of breastfeeding in newborns with...

Authors: G Salvatori, S Foligno, M Massoud, F Piersigilli, P Bagolan and A Dotta

Common symptoms for a rare disease in a girl with sarcoidosis: a case report

Sarcoidosis in pediatric age is uncommon and challenging diagnosis, because manifestations can be significantly variable and non-specific since it is a multisystem disease, and virtually any organ system may b...

Authors: Mattia Giovannini, Michele Luzzati, Giovanna Ferrara, Anna Maria Buccoliero, Gabriele Simonini, Maurizio de Martino, Rolando Cimaz and Teresa Giani

Secondary prevention of early-onset sepsis: a less invasive Italian approach for managing neonates at risk

Strategies to prevent early-onset sepsis (EOS) have led to a substantial decline in many countries. However, one of the most controversial topics in neonatology is the management of asymptomatic full-term and ...

Authors: Alberto Berardi, Chryssoula Tzialla, Laura Travan, Jenny Bua, Daniele Santori, Milena Azzalli, Caterina Spada and Laura Lucaccioni

Mortality rate of patients with cystic fibrosis on the waiting list and within one year after lung transplantation: a survey of Italian CF centers

Cystic Fibrosis (CF) Centers are involved in the decisions regarding the eligibility of CF patients with end-stage lung disease and timing for inclusion on waiting lists (WL) for lung transplantation (LT). The...

Authors: Beatrice Borchi, Marisol Barao Ocampo, Giuseppe Cimino, Giovanna Pizzamiglio, Silvia Bresci and Cesare Braggion

Acute mastoiditis in an Italian pediatric tertiary medical center: a 15 – year retrospective study

Acute mastoiditis is the main suppurative complication of acute otitis media. Its incidence ranges from 1.2 to 4.2/100.000 children/year and a rise has been reported in the last years. There are controversial ...

Authors: Claudia Balsamo, Carlotta Biagi, Margherita Mancini, Ilaria Corsini, Rosalba Bergamaschi and Marcello Lanari

Intermittent oral levetiracetam reduced recurrence of febrile seizure accompanied with epileptiform discharge: a pilot study

In previous study, we have found intermittent oral levetiracetam (LEV) can effectively prevent recurrence of febrile seizure (FS). This study aimed to analyze the effects of the preventive on the patients with...

Authors: Lin-Yan Hu, Xiu-Yu Shi, Hui Li, Meng-Na Zhang, Shu-Fang Ma and Li-Ping Zou

Media devices in pre-school children: the recommendations of the Italian pediatric society

Young children are too often exposed to mobile devices (MD) and most of them had their own device. The adverse effects of a early and prolonged exposure to digital technology on pre-school children has been de...

Authors: Elena Bozzola, Giulia Spina, Margherita Ruggiero, Luigi Memo, Rino Agostiniani, Mauro Bozzola, Giovanni Corsello and Alberto Villani

The impact of nasal aspiration with an automatic device on upper and lower respiratory symptoms in wheezing children: a pilot case-control study

The impact of proper aspiration of nasal secretions during upper respiratory infection on the frequency and severity of symptoms of lower airways has never been investigated. The study was aimed at testing if ...

Authors: Antonio Pizzulli, Serena Perna, Anja Bennewiz, Holger Roeblitz, Salvatore Tripodi, Jakob Florack, Petra Wagner, Stephanie Hofmaier and Paolo Maria Matricardi

Mandatory vaccinations in European countries, undocumented information, false news and the impact on vaccination uptake: the position of the Italian pediatric society

High rates of vaccination coverage are important in preventing infectious diseases. Enforcing mandatory vaccinations is one of the strategies that some Countries adopted to protect the community when vaccinati...

Authors: Elena Bozzola, Giulia Spina, Rocco Russo, Mauro Bozzola, Giovanni Corsello and Alberto Villani

Indications and complications of inpatient parenteral nutrition prescribed to children in a large tertiary referral hospital

Parenteral Nutrition (PN) is prescribed to children with intestinal failure. Although life saving, complications are common. Recommendations for indications and constituents of PN are made in the 2005 guidelin...

Authors: C. Mantegazza, N. Landy, G. V. Zuccotti and J. Köglmeier

Impact of family integrated care on infants’ clinical outcomes in two children’s hospitals in China: a pre-post intervention study

Most Neonatal Intensive Care Units (NICUs) in China have restricted visiting policies for parents. This also implicates that parents are not involved in the care of their infant. Family Integrated Care (FIC), ...

Authors: Shi-wen He, Yue-e Xiong, Li-hui Zhu, Bo Lv, Xi-rong Gao, Hua Xiong, Huan Wang, Hua-rong Shi and Jos M. Latour

Oral administration of tannins and flavonoids in children with acute diarrhea: a pilot, randomized, control-case study

AG is the most common cause of pediatric consultations among children between 2 and 5 years of age and it still leads to high mortality and morbidity. Its management is based on rehydration therapy, but this t...

Authors: Marina Russo, Vincenzo Coppola, Eleonora Giannetti, Roberta Buonavolontà, Antonio Piscitelli and Annamaria Staiano

A comparison of the effect of xinruibai versus filgrastim on hematopoietic reconstruction after allogeneic hematopoietic stem cell transplantation

To compare the effect of xinruibai (Pegfilgrastim) and filgrastim injections on white blood cell and platelet (PLT) recovery, adverse events, post-operative complications, and cost effectiveness after allogene...

Authors: Qixiang Ye, Hebi Jiang and Hua Jiang

A cohort study on acute ocular motility disorders in pediatric emergency department

Acute ocular motility disorders (OMDs) in children admitted to Emergency Department (ED) represents a not so rare condition with a wide spectrum of different etiologies. The emergency physician must be skilled...

Authors: Umberto Raucci, Pasquale Parisi, Nicola Vanacore, Valentina Ferro, Giacomo Garone, Federica Sancetta, Sergio Petroni, Stefano Pro, Rossella Rossi, Antonino Reale and Nicola Pirozzi

Level of modern health care seeking behaviors among mothers having under five children in Dangila town, north West Ethiopia, 2016: a cross sectional study

Health seeking behavior is an action taken by an individual who perceive to have a health problem. In most developing countries including Ethiopia the health of the children is strongly dependant on maternal h...

Authors: Amare Belachew Dagnew, Tilahun Tewabe and Rajalakshmi Murugan

Impact of near infrared light in pediatric blood drawing Centre on rate of first attempt success and time of procedure

Peripheral blood access and venipuncture are a stressful and painful experience in pediatric patients; moreover, it is estimated that more than one attempt is required to achieve the procedure in about one thi...

Authors: Ester Conversano, Giorgio Cozzi, Matteo Pavan, Marta Minute, Elena Gortan, Marcella Montico, Liza Vecchi Brumatti, Luca Ronfani and Egidio Barbi

Currarino syndrome and microcephaly due to a rare 7q36.2 microdeletion: a case report

Currarino syndrome is a rare condition characterized by presacral mass, anorectal malformation and sacral dysgenesis.

Authors: Lucia Cococcioni, Susanna Paccagnini, Elena Pozzi, Luigina Spaccini, Elisa Cattaneo, Serena Redaelli, Francesca Crosti and Gian Vincenzo Zuccotti

Management of undescended testis may be improved with educational updates and new transferring model

To investigate whether management of undescended testis (UDT) may be improved with educational updates and new transferring model among referring providers (RPs).

Authors: Wei Yi, Wu Sheng-de, Shen Lian-Ju, Lin Tao, He Da-wei and Wei Guang-hui

Neonatal mortality in the case of Felege Hiwot referral hospital, Bahir Dar, Amhara Regional State, North West Ethiopia 2016: a one year retrospective chart review

Ethiopia is among the countries with the highest neonatal mortality with the rate of 37 deaths per 1000 live births. In spite of many efforts by the government and other partners, non significant decline has b...

Authors: Tilahun Tewabe, Yenatfanta Mehariw, Eyerusalem Negatie and Bertukan Yibeltal

Prevalence of electrolyte disturbances in perinatal asphyxia: a prospective study

Birth asphyxia is defined as the presence of hypoxia, hypercapnia, and acidosis leading the newborn to systemic disturbances probably electrolyte disturbance also. Knowledge of these electrolyte disturbances i...

Authors: Jitendra Thakur, Nisha Keshary Bhatta, Rupa Rajbhandari Singh, Prakash Poudel, Madhab Lamsal and Anjum Shakya

Inhaled nitric oxide as a rescue therapy in a preterm neonate with severe pulmonary hypertension: a case report

Inhaled nitric oxide (iNO) has been approved for the treatment of persistent pulmonary hypertension of the newborn (PPHN) in term and near-term newborns. Its role in the management of persistent pulmonary hype...

Authors: Martina Busè, Francesco Graziano, Fabio Lunetta, Giorgio Sulliotti and Vincenzo Duca

Benign and severe early-life seizures: a round in the first year of life

At the onset, differentiation between abnormal non-epileptic movements, and epileptic seizures presenting in early life is difficult as is clinical diagnosis and prognostic evaluation of the various seizure di...

Authors: Piero Pavone, Giovanni Corsello, Martino Ruggieri, Silvia Marino, Simona Marino and Raffaele Falsaperla

Does a low FODMAPs diet reduce symptoms of functional abdominal pain disorders? A systematic review in adult and paediatric population, on behalf of Italian Society of Pediatrics

Despite the rising of the Functional Gastrointestinal Disorders (FGIDs)’ incidence in the last years, the etio-pathogenesis of FGIDs remains unclear. The diet seems to play an important role in these disorders...

Authors: Rossella Turco, Silvia Salvatore, Erasmo Miele, Claudio Romano, Gian Luigi Marseglia and Annamaria Staiano

Metabolic acidosis as Food Protein Induced Enterocolitis Syndrome (FPIES) onset in a newborn

FPIES (Food Protein Induced Eneterolitis Syndrome) is a rare non IgE- mediated food allergy, usually affecting infants and children after first months of life. Clinical presentation is heterogeneous, usually c...

Authors: Antonella Peduto, Mario Rocca, Cinzia De Maio, Federica Gallarotti, Giulia Pomero and Paolo Gancia

Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians

Vitamin D plays a pivotal role in the regulation of calcium-phosphorus metabolism, particularly during pediatric age when nutritional rickets and impaired bone mass acquisition may occur.

Authors: Giuseppe Saggese, Francesco Vierucci, Flavia Prodam, Fabio Cardinale, Irene Cetin, Elena Chiappini, Gian Luigi de’ Angelis, Maddalena Massari, Emanuele Miraglia Del Giudice, Michele Miraglia Del Giudice, Diego Peroni, Luigi Terracciano, Rino Agostiniani, Domenico Careddu, Daniele Giovanni Ghiglioni, Gianni Bona…

Human respiratory syncytial virus and hospitalization in young children in Italy

Human respiratory syncytial virus (hRSV) is ubiquitous and causes respiratory diseases in both children and adults. Worldwide, hRSV pneumonia is the second cause of postnatal infant death after malaria. Given ...

Authors: Parvanè Kuhdari, Federica Brosio, Cristina Malaventura, Armando Stefanati, Andrea Orsi, Giancarlo Icardi and Giovanni Gabutti

Baby-led weaning: what a systematic review of the literature adds on

The term weaning describes the time period in which a progressive reduction of breastfeeding or the feeding of infant-formula takes place while the infant is gradually introduced to solid foods. It is a crucia...

Authors: Enza D’Auria, Marcello Bergamini, Annamaria Staiano, Giuseppe Banderali, Erica Pendezza, Francesca Penagini, Gian Vincenzo Zuccotti and Diego Giampietro Peroni

Improved dietary diversity of school adolescent girls in the context of urban Northwest Ethiopia: 2017

Undiversified diet increases the vulnerability of adolescents for different nutritional problems. Therefore, this study assessed dietary and associated factors among school adolescent girls in Gondar city, nor...

Authors: Samuel Mersha Birru, Amare Tariku and Aysheshim Kassahun Belew

Congenital hypopituitarism: how to select the patients for genetic analyses

Aim of this commentary is to analyze the relationships between genotypic bases and phenotypic expression of congenital “multiple pituitary hormone deficiency” (MPHD) syndrome and to indicate some reliable crit...

Authors: Giuseppe Crisafulli, Tommaso Aversa, Giuseppina Zirilli, Filippo De Luca, Romina Gallizzi and Malgorzata Wasniewska

Guideline on management of the acute asthma attack in children by Italian Society of Pediatrics

Acute asthma attack is a frequent condition in children. It is one of the most common reasons for emergency department (ED) visit and hospitalization. Appropriate care is fundamental, considering both the high...

Authors: Luciana Indinnimeo, Elena Chiappini and Michele Miraglia del Giudice

Clinical and molecular characterization of 112 single-center patients with Neurofibromatosis type 1

The aim of this retrospective study was to define clinical and molecular characteristics of a large sample of neurofibromatosis type 1 (NF1) patients, as well as to evaluate mutational spectrum and genotype-ph...

Authors: Giovanni Corsello, Vincenzo Antona, Gregorio Serra, Federico Zara, Clara Giambrone, Luca Lagalla, Maria Piccione and Ettore Piro

Clinical characteristics of headache in Italian adolescents aged 11–16 years: a cross-sectional questionnaire school-based study

The purpose of this study was to determine headache characteristics, impact on daily activities and medication attitudes among a large sample of adolescents in Italy.

Authors: Thomas Foiadelli, Alessandra Piccorossi, Lucia Sacchi, Mara De Amici, Maurizio Tucci, Ilaria Brambilla, Gian Luigi Marseglia, Salvatore Savasta and Alberto Verrotti

A Klinefelter boy with congenital adrenal hyperplasia: too much or too little androgens?

The simultaneous occurrence of Klinefelter Syndrome (KS) and Congenital Adrenal Hyperplasia (CAH) is an exceptional event: there are just three case reports (two children and a 51 years old man) describing mal...

Authors: Giada Zanella, Gianluca Tornese, Elisabetta Mascheroni, Elena Faleschini, Alessandro Ventura and Egidio Barbi

Pleural effusion from intrathoracic migration of a ventriculo-peritoneal shunt catheter: pediatric case report and review of the literature

Pleural effusion is a rare complication of ventriculo-peritoneal (VP) cerebrospinal fluid (CSF) shunting and its diagnosis is difficult in patients with neurological and consciousness impairment.

Authors: Federica Porcaro, Emidio Procaccini, Maria Giovanna Paglietti, Alessandra Schiavino, Francesca Petreschi and Renato Cutrera

Seizures in children with neurofibromatosis type 1: is neurofibromatosis type 1 enough?

Neurofibromatosis type 1 (NF1) is related to a generally increased prevalence of seizures. The mechanism underlying the increased predisposition to seizures has not been fully elucidated. The aim of the study ...

Authors: Claudia Santoro, Pia Bernardo, Antonietta Coppola, Umberto Pugliese, Mario Cirillo, Teresa Giugliano, Giulio Piluso, Giuseppe Cinalli, Salvatore Striano, Carmela Bravaccio and Silverio Perrotta

Vitamin D levels and parathyroid hormone variations of children living in a subtropical climate: a data mining study

Vitamin D and intact parathyroid hormone (iPTH) play a crucial role in calcium homeostasis and bone health of children. Serum level of 25-hydroxyvitamin D (25-OHD) is considered to be the most accurate marker ...

Authors: Ozlem Naciye Sahin, Muhittin Serdar, Mustafa Serteser, Ibrahim Unsal and Aysel Ozpinar

Epidemiological and clinical aspects of autoimmune thyroid diseases in children with Down’s syndrome

Aim of this commentary is to report the main peculiarities that have been found to characterize the phenotypic expression of autoimmune thyroid diseases (AITDs) in children with Down’s syndrome (DS). According...

Authors: Tommaso Aversa, Giuseppe Crisafulli, Giuseppina Zirilli, Filippo De Luca, Romina Gallizzi and Mariella Valenzise

The relationship between body mass index and children’s presentations to a tertiary pediatric emergency department

The child obesity and its complications are associated with an alarming increased health care use, including the emergency department (ED). We evaluated the effects of the obesity and overweight in children ad...

Authors: Valentina Ferro, Antonella Mosca, Francesca Crea, Maria Alessia Mesturino, Carla Olita, Andrea Vania, Antonino Reale, Valerio Nobili and Umberto Raucci

Dolutegravir-based anti-retroviral therapy is effective and safe in HIV–infected paediatric patients

Treatment of HIV infection in adolescents is challenging due to long duration of therapy and poor adherence. Recently, the integrase strand transfer inhibitor dolutegravir (DTG) has been approved for the use i...

Authors: Eugenia Bruzzese, Andrea Lo Vecchio, Andrea Smarrazzo, Orsola Tambaro, Giulia Palmiero, Giovanni Bonadies and Alfredo Guarino

Vitamin K deficiency: a case report and review of current guidelines

Vitamin K, a fat soluble vitamin, is a necessary cofactor for the activation of coagulation factors II, VII, IX, X, and protein C and S. In neonatal period, vitamin K deficiency may lead to Vitamin K Deficienc...

Authors: Maria Rosaria Marchili, Elisa Santoro, Alessandra Marchesi, Simona Bianchi, Lelia Rotondi Aufiero and Alberto Villani

Guidelines on pediatric day surgery of the Italian Societies of Pediatric Surgery (SICP) and Pediatric Anesthesiology (SARNePI)

The Italian Society of Pediatric Surgery (SICP) together with The Italian Society of Pediatric Anesthesia (SARNePI) through a systematic analysis of the scientific literature, followed by a consensus conferenc...

Authors: Ugo de Luca, Giovanni Mangia, Simonetta Tesoro, Ascanio Martino, Maria Sammartino and Alessandro Calisti

Prematurity, ventricular septal defect and dysmorphisms are independent predictors of pathogenic copy number variants: a retrospective study on array-CGH results and phenotypical features of 293 children with neurodevelopmental disorders and/or multiple congenital anomalies

Since 2010, array-CGH (aCGH) has been the first-tier test in the diagnostic approach of children with neurodevelopmental disorders (NDD) or multiple congenital anomalies (MCA) of unknown origin. Its broad appl...

Authors: I. Maini, I. Ivanovski, O. Djuric, S. G. Caraffi, E. Errichiello, M. Marinelli, F. Franchi, V. Bizzarri, S. Rosato, M. Pollazzon, C. Gelmini, M. Malacarne, C. Fusco, G. Gargano, S. Bernasconi, O. Zuffardi…

A comparison of efficacy of six prediction models for intravenous immunoglobulin resistance in Kawasaki disease

Kawasaki disease (KD) is the most common pediatric vasculitis. Several models have been established to predict intravenous immunoglobulin (IVIG) resistance. The present study was aimed to evaluate the efficacy...

Authors: Weiguo Qian, Yunjia Tang, Wenhua Yan, Ling Sun and Haitao Lv

One in three adolescent schoolgirls in urban northwest Ethiopia is stunted

Poor nutritional status of adolescent girls has a negative effect on the next generation as undernourished adolescents enter pregnancy with poor nutrient reserve. However, there is scarcity of evidence showing...

Authors: Samuel Mersha Birru, Aysheshim Kassahun Belew and Amare Tariku

What family doctors know about congenital CMV: a regional survey in Iran

Since there is no effective treatment or vaccine against the congenital cytomegalovirus (cCMV) infection, knowledge and awareness of medical doctor’s (MDs) especially family doctors are essential for preventiv...

Authors: Ahmad Hosseinzadeh Adli, Chiman Karami, Sanaz Baghban Rahimi, Azam Mirarab and Alijan Tabarraei

Detection of IL10-producing B cell (B10) in adenoids of atopic children with adenoidal hypertrophy

Authors: Chiara Valsecchi, Sara Carlotta Tagliacarne, Ilaria Brambilla, Catherine Klersy, Marco Benazzo, Lorenza Montagna, Dimitri Poddighe, Giorgio Ciprandi, Gian Luigi Marseglia, Amelia Licari and Annamaria Castellazzi