Articles

Technical realization of a sensorized neonatal intubation skill trainer for operators’ retraining and a pilot study for its validation

In neonatal endotracheal intubation, excessive pressure on soft tissues during laryngoscopy can determine permanent injury. Low-fidelity skill trainers do not give valid feedback about this issue. This study d...

Authors: Davide Panizza, Rosa T. Scaramuzzo, Francesca Moscuzza, Ilaria Vannozzi, Massimiliano Ciantelli, Marzia Gentile, Ilaria Baldoli, Selene Tognarelli, Antonio Boldrini and Armando Cuttano

S737F is a new CFTR mutation typical of patients originally from the Tuscany region in Italy

An increasing number of patients have been described as having a number of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) variants for which it lacks a clear genotype–phenotype correlation. We assesse...

Authors: Vito Terlizzi, Antonella Miriam Di Lullo, Marika Comegna, Claudia Centrone, Elisabetta Pelo, Giuseppe Castaldo, Valeria Raia and Cesare Braggion

Gender disparity in pediatrics: a review of the current literature

Gender-based medicine is an innovative branch of biomedical research and represents a new perspective for the future of health research. Many studies have been published on gender medicine in adults but very f...

Authors: Paola Piccini, Carlotta Montagnani and Maurizio de Martino

A pediatric disease to keep in mind: diagnostic tools and management of bronchiectasis in pediatric age

Bronchiectasis in pediatric age is a heterogeneous disease associated with significant morbidity.

Authors: Marcella Gallucci, Emanuela di Palmo, Luca Bertelli, Federica Camela, Giampaolo Ricci and Andrea Pession

Nasal high flow therapy in very low birth weight infants with mild respiratory distress syndrome: a single center experience

Pulmonary disorders and respiratory failure represent one of the most common morbidities of preterm newborns admitted to neonatal intensive care units (NICUs). The use of nasal high-flow therapy (nHFT) has bee...

Authors: Antonio Di Mauro, Manuela Capozza, Sergio Cotugno, Silvio Tafuri, Francesco Paolo Bianchi, Federico Schettini, Raffaella Panza and Nicola Laforgia

Correction to: Neuropsychological and internalizing problems in acute central nervous system infections: a 1 year follow-up

The original article [1] contained an error mistakenly carried forward by the Production department handling this article whereby all authors’ names were incorrectly inverted.

Authors: Elena Bozzola, Paola Bergonzini, Mauro Bozzola, Alberto Eugenio Tozzi, Marco Masci, Chiara Rossetti, Emanuela Carloni and Alberto Villani

Management of pneumothorax in hemodynamically stable preterm infants using high frequency oscillatory ventilation: report of five cases

Despite an increased use of non-invasive ventilatory strategies and gentle ventilation, pneumothorax remains a common complication in preterm infants. The ventilator management of infants with air leaks remain...

Authors: Claudia Aurilia, Cinzia Ricci, Milena Tana, Chiara Tirone, Alessandra Lio, Alessandro Gambacorta, Angela Paladini and Giovanni Vento

Monitoring adherence to guidelines of antibiotic use in pediatric pneumonia: the MAREA study

Children are the most vulnerable population exposed to the use of antibiotics often incorrectly prescribed for the treatment of infections really due to viruses rather than to bacteria. We designed the MAREA s...

Authors: Pasquale Di Pietro, Ornella Della Casa Alberighi, Michela Silvestri, Maria Angela Tosca, Anna Ruocco, Giorgio Conforti, Giovanni A. Rossi, Elio Castagnola, Maria Caterina Merlano, Simona Zappettini and Salvatore Renna

73rd Congress of the Italian Society of Pediatrics

Authors:

Stunting and its determinant factors among children aged 6–59 months in Ethiopia

Though Ethiopia has implemented different nutritional interventions, childhood stunting on which literature is limited continues as a severe public health problem. Thus, this study aimed to investigate stuntin...

Authors: Amare Tariku, Gashaw Andargie Biks, Terefe Derso, Molla Mesele Wassie and Solomon Mekonnen Abebe

Apparent Life-Threatening Events (ALTE): Italian guidelines

Five years after the first edition, we have revised and updated the guidelines, re-examining the queries and relative recommendations, expanding the issues addressed with the introduction of a new entity, rece...

Authors: Raffaele Piumelli, Riccardo Davanzo, Niccolò Nassi, Silvia Salvatore, Cinzia Arzilli, Marta Peruzzi, Massimo Agosti, Antonella Palmieri, Maria Giovanna Paglietti, Luana Nosetti, Raffaele Pomo, Francesco De Luca, Alessandro Rimini, Salvatore De Masi, Simona Costabel, Valeria Cavarretta…

Age and seasons influence on at-home pulse oximetry results in children evaluated for suspected obstructive sleep apnea

Seasonal variability on obstructive sleep apnea has already been studied by polysomnography in children. Winter and spring season emerged as critical periods. No data are currently available for pulse oximetry...

Authors: Martino Pavone, Elisabetta Verrillo, Nicola Ullmann, Serena Caggiano, Valentina Negro and Renato Cutrera

MTHFR A1298C polymorphisms reduce the risk of congenital heart defects: a meta-analysis from 16 case-control studies

Methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in the hyperhomocysteinemia, which is a risk factor related to the occurrence of congenital heart defect (CHD). However, the association between...

Authors: Di Yu, Zhulun Zhuang, Zhongyuan Wen, Xiaodong Zang and Xuming Mo

Impact of adenotonsillectomy on pediatric quality of life: review of the literature

Adenotonsillectomy (ADT) is one of the most widely used procedures in the treatment of paediatric recurrent acute tonsillitis (RAT) and obstructive sleep apnoea syndrome (OSAS), both of which have significant ...

Authors: Sara Torretta, Chiara Rosazza, Maria Elisabetta Pace, Elisabetta Iofrida and Paola Marchisio

The involvement of musculoskeletal system and its influence on postural stability in children and young adults with cystic fibrosis

Cystic fibrosis (CF) affects the musculoskeletal system via a multifactorial pathway that includes vitamin D deficiency and involvement of respiratory muscles such as intercostals due to recurrent upper and lo...

Authors: Ozge Kenis-Coskun, Evrim Karadag-Saygi, Yeliz Bahar-Ozdemir, Yasemin Gokdemir, Bulent Karadag and Onder Kayhan

Telemedicine as an effective intervention to improve antibiotic appropriateness prescription and to reduce costs in pediatrics

Implementation of antimicrobial stewardship program is a pivotal practice element for healthcare institution. We developed a remote infectious disease consultancy program via telemedicine in a high-specialized...

Authors: Jacopo Ceradini, Alberto Eugenio Tozzi, Patrizia D’Argenio, Paola Bernaschi, Lucia Manuri, Carla Brusco and Massimiliano Raponi

Anaphylactic shock with methylprednisolone sodium succinate in a child with short bowel syndrome and cow’s milk allergy

Medications with methyl-prednisolone sodium succinate containing lactose, which potentially contains traces of cow’s milk proteins (CMP), could cause allergic reactions or compromise treatment of acute allergi...

Authors: Federica Porcaro, Maria Giovanna Paglietti, Antonella Diamanti, Francesca Petreschi, Alessandra Schiavino, Valentina Negro, Valentina Pecora, Alessandro Fiocchi and Renato Cutrera

Cardiac arrest in a toddler treated with propranolol for infantile Hemangioma: a case report

Propranolol has become the first-line treatment for complicated Infantile Hemangioma (IH), showing so far a good risk-benefit profile.

Authors: Alvise Tosoni, Mario Cutrone, Maurizio Dalle Carbonare, Andrea Pettenazzo, Giorgio Perilongo and Stefano Sartori

Measles lessons in an anti-vaccination era: public health is a social duty, not a political option

Measles virus, member of the genus Morbillivirus in the family Paramyxoviridae, is a highly contagious human pathogen. An effective live-attenuated vaccine is available and its use has the potential to eradica...

Authors: L. Lancella, C. Di Camillo, A. C. Vittucci, E. Boccuzzi, E. Bozzola and A. Villani

Congenital myopathies: clinical phenotypes and new diagnostic tools

Congenital myopathies are a group of genetic muscle disorders characterized clinically by hypotonia and weakness, usually from birth, and a static or slowly progressive clinical course. Historically, congenita...

Authors: Denise Cassandrini, Rosanna Trovato, Anna Rubegni, Sara Lenzi, Chiara Fiorillo, Jacopo Baldacci, Carlo Minetti, Guja Astrea, Claudio Bruno and Filippo M. Santorelli

Intersociety policy statement on the use of whole-exome sequencing in the critically ill newborn infant

The rapid advancement of next-generation sequencing (NGS) technology and the decrease in costs for whole-exome sequencing (WES) and whole-genome sequening (WGS), has prompted its clinical application in severa...

Authors: Alessandro Borghesi, Maria Antonietta Mencarelli, Luigi Memo, Giovanni Battista Ferrero, Andrea Bartuli, Maurizio Genuardi, Mauro Stronati, Alberto Villani, Alessandra Renieri and Giovanni Corsello

Clinical spectrum of woolly hair: indications for cerebral involvement

Woolly Hair is an uncommon congenital anomaly of the scalp hair presenting with strongly coiled hair involving a localized area of the scalp or covering the entire side and occurring in non-black people. Isola...

Authors: Piero Pavone, Raffaele Falsaperla, Massimo Barbagallo, Agata Polizzi, Andrea D. Praticò and Martino Ruggieri

Strategies for preventing group B streptococcal infections in newborns: a nation-wide survey of Italian policies

There are no Italian data regarding the strategies for preventing neonatal group B streptococcal (GBS) infection. We conducted a national survey in order to explore obstetrical, neonatal and microbiological pr...

Authors: Chryssoula Tzialla, Alberto Berardi, Claudio Farina, Pierangelo Clerici, Alessandro Borghesi, Elsa Viora, Paolo Scollo and Mauro Stronati

Hereditary neuropathy with liability to pressure palsy (HNPP): report of a family with a new point mutation in PMP22 gene

Hereditary neuropathy with liability to pressure palsy (HNPP) is an autosomal dominant disorder most commonly presenting with acute-onset, non-painful focal sensory and motor mononeuropathy. Approximately 80% ...

Authors: Carlo Fusco, Carlotta Spagnoli, Grazia Gabriella Salerno, Elena Pavlidis, Daniele Frattini and Francesco Pisani

Neuropsychological and internalizing problems in acute central nervous system infections: a 1 year follow-up

Acute central nervous system (ACNS) infections such as meningitis, encephalitis and cerebellitis still cause morbidity and mortality among children. The aim of this study was to verify whether neuropsychologic...

Authors: Elena Bozzola, Paola Bergonzini, Mauro Bozzola, Alberto Eugenio Tozzi, Marco Masci, Chiara Rossetti, Emanuela Carloni and Alberto Villani

How should we give vitamin D supplementation? evaluation of the pediatricians’ knowledge in Turkey

We aimed to determine the knowledge and attitudes of Turkish pediatricians concerning vitamin D supplement.

Authors: Gizem Kara Elitok, Lida Bulbul, Umut Zubarioglu, Evrim Kıray Bas, Duygu Acar, Sinan Uslu and Ali Bulbul

Compound heterozygosity for two GHR missense mutations in a patient affected by Laron Syndrome: a case report

Mutations localized in the Growth Hormone Receptor (GHR) gene are often associated with the pathogenesis of Laron Syndrome, an autosomal recessive hereditary disorder characterized by severe growth retardation...

Authors: Stefania Moia, Daniele Tessaris, Silvia Einaudi, Luisa de Sanctis, Gianni Bona, Simonetta Bellone and Flavia Prodam

Specific IgE and skin prick tests to diagnose allergy to fresh and baked cow’s milk according to age: a systematic review

The diagnosis of IgE-mediated cow’s milk allergy is often based on anamnesis, and on specific IgE (sIgE) levels and/or Skin Prick Tests (SPT), which have both a good sensitivity but a low specificity, often ca...

Authors: Barbara Cuomo, Giovanni Cosimo Indirli, Annamaria Bianchi, Stefania Arasi, Davide Caimmi, Arianna Dondi, Stefania La Grutta, Valentina Panetta, Maria Carmen Verga and Mauro Calvani

First case of Mycobacterium marseillense lymphadenitis in a child

Nontuberculous mycobacteria (NTM) are pathogens that commonly affect the paediatric population and its most frequent manifestation is a cervicofacial lymphadenopathy. With the improvement of technologies, new ...

Authors: A. Azzali, C. Montagnani, M. T. Simonetti, G. Spinelli, M. de Martino and L. Galli

Childhood diarrheal morbidity and sanitation predictors in a nomadic community

Diarrhea remains a leading killer of young children on the globe despite the availability of simple and effective solutions to prevent and control it. The disease is more prevalent among under – five children ...

Authors: Bikes Destaw Bitew, Wondwoson Woldu and Zemichael Gizaw

Object permanence and the development of attention capacity in preterm and term infants: an eye-tracking study

The relationship between premature birth and early cognitive function as measured by eye-tracking data remains unexplored. The aim of this study was to determine the effect of prematurity on the development of...

Authors: Hokyoung Ryu, Garam Han, Jaeran Choi, Hyun-Kyung Park, Mi Jung Kim, Dong-Hyun Ahn and Hyun Ju Lee

Efficacy and usability of a novel nebulizer targeting both upper and lower airways

Upper and lower airways diseases share in part their pathogenic mechanisms and frequently occur simultaneously as “United Airway Disease.” Local treatment with nebulizers delivers anti-symptomatic drugs in eit...

Authors: Daniela Posa, Antonio Pizzulli, Petra Wagner, Serena Perna, Stephanie Hofmaier, Paolo Maria Matricardi and Susanne Lau

NBAS mutations cause acute liver failure: when acetaminophen is not a culprit

Pediatric acute-liver-failure due to acetaminophen (APAP) administration at therapeutic dosage is rare, while viral infections and metabolic defects are the prevalent causes. Yet, as acetaminophen is routinely...

Authors: Pier Luigi Calvo, Francesco Tandoi, Tobias B. Haak, Andrea Brunati, Michele Pinon, Dominic Dell Olio, Renato Romagnoli and Marco Spada

Congenital hypothyroidism due to ectopic sublingual thyroid gland in Prader-Willi Syndrome: a case report

Thyroid gland disorders are variably associated with Prader-Willi syndrome (PWS).

Authors: Sarah Bocchini, Danilo Fintini, Graziano Grugni, Arianna Boiani, Alessio Convertino and Antonino Crinò

Iron deficiency parameters in autism spectrum disorder: clinical correlates and associated factors

High prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) has been reported in children with autism spectrum disorder (ASD). However, there is a limited number of studies about the association b...

Authors: Serkan Gunes, Ozalp Ekinci and Tanju Celik

Liver chemistry in new-onset Henoch-Schönlein syndrome

Henoch-Schönlein syndrome is a systemic small-vessel leukocytoclastic vasculitis that usually present with cutaneous, gastrointestinal, articular and renal manifestations. Little is known on liver involvement ...

Authors: Giulia Rosti, Gregorio P. Milani, Emanuela A. Laicini, Emilio F. Fossali and Mario G. Bianchetti

Conduct disorders and psychopathy in children and adolescents: aetiology, clinical presentation and treatment strategies of callous-unemotional traits

Conduct Disorder (CD) is a psychiatric diagnosis characterized by a repetitive and persistent pattern of behaviour in which the basic rights of others and major age-appropriate social norms or rules are violat...

Authors: Simone Pisano, Pietro Muratori, Chiara Gorga, Valentina Levantini, Raffaella Iuliano, Gennaro Catone, Giangennaro Coppola, Annarita Milone and Gabriele Masi

Long-term outcome of autistic spectrum disorder: a retrospective case study in a southern italian region

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, characterized by impaired social communication and restricted and repetitive behaviours, as well as associated features including intell...

Authors: Francesca Felicia Operto, Federica Martino, Annalisa Rinaldi, Angelo Cerracchio, Giovanni Salvati, Mariano Orza, Claudia Lembo, Gianvito Panzarino, Claudia Di Paolantonio, Alberto Verrotti, Giovanni Farello and Giangennaro Coppola

Newborn hearing screening protocol in tuscany region

Newborn hearing screening has to be considered the first step of a program for the identification, diagnosis, treatment and habilitation/rehabilitation of children with hearing impairment.

Authors: Stefano Berrettini, Paolo Ghirri, Francesco Lazzerini, Giovanni Lenzi and Francesca Forli

Possible effects of an early diagnosis and treatment in patients with growth hormone deficiency: the state of art

Growth hormone deficiency (GHD) is a relatively uncommon and heterogeneous endocrine disorder presenting in childhood with short stature. However, during the neonatal period, the metabolic effects of GHD may t...

Authors: Stefano Stagi, Perla Scalini, Giovanni Farello and Alberto Verrotti

Advances in paediatrics in 2016: current practices and challenges in allergy, autoimmune diseases, cardiology, endocrinology, gastroenterology, infectious diseases, neonatology, nephrology, neurology, nutrition, pulmonology

This review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several d...

Authors: Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Silvia Montella and Sergio Bernasconi

A comparison of blood stream infections with extended spectrum beta-lactamase-producing and non-producing Klebsiella pneumoniae in pediatric patients

Rapid development and global spread of multidrug resistant Klebsiella pneumonia (K. pneumoniae) as a major cause of nosocomial infections is really remarkable. The aim of this study was to explore risk factors fo...

Authors: Sevgen Tanır Basaranoglu, Yasemin Ozsurekci, Kubra Aykac, Eda Karadag Oncel, Asiye Bıcakcigil, Banu Sancak, Ali Bulent Cengiz, Ates Kara and Mehmet Ceyhan

Long-term treatment with low-dose medicine in chronic childhood eczema: a double-blind two-stage randomized control trial

The efficacy of low-dose medicine (LDM) in childhood mild/moderate eczema is not known. We conducted a double-blind, two-stage, randomized, placebo-controlled clinical trial, lasting 23 months, to address this...

Authors: R. Carello, L. Ricottini, V. Miranda, P. Panei, L. Rocchi, R. Arcieri and E. Galli

Respiratory problems in children with esophageal atresia and tracheoesophageal fistula

Children with congenital esophageal atresia (EA) and tracheoesophageal fistula (TEF) have chronic respiratory symptoms including recurrent pneumonia, wheezing and persistent cough. The aim of this study is to ...

Authors: Federica Porcaro, Laura Valfré, Lelia Rotondi Aufiero, Luigi Dall’Oglio, Paola De Angelis, Alberto Villani, Pietro Bagolan, Sergio Bottero and Renato Cutrera

Humanization of pediatric care in the world: focus and review of existing models and measurement tools

The term “humanization” indicates the process by which people try to make something more human and civilized, more in line with what is believed to be the human nature. The humanization of care is an important...

Authors: Marina Tripodi, Maria Anna Siano, Claudia Mandato, Anna Giulia Elena De Anseris, Paolo Quitadamo, Salvatore Guercio Nuzio, Claudia Viggiano, Francesco Fasolino, Annalisa Bellopede, Maria Annunziata, Grazia Massa, Francesco Maria Pepe, Maria De Chiara, Paolo Siani and Pietro Vajro

Validation of the Italian version of the Non-Communicating Children's Pain Checklist-Postoperative Version

This study evaluated the validity and reliability of the Italian version of the Non-Communicating Children’s Pain Checklist-Postoperative version (I-NCCPC-PV).

Authors: C. Zanchi, M. Massaro, G. Ferrara, M. Montico, F. D’Osualdo, R. Rutigliano, A. Taddio, L. Vecchi Brumatti, G. Cozzi and E. Barbi

Mediterranean diet, folic acid, and neural tube defects

The Mediterranean diet has been for a very long time the basis of food habits all over the countries of the Mediterranean basin, originally founded on rural models and low consumption of meat products and high...

Authors: Maximilian Fischer, Mauro Stronati and Marcello Lanari

Dietary diversity and meal frequency among infant and young children: a community based study

Insufficient quantities, frequencies, and inadequate quality of complementary feedings have a negative effect on child health and growth, especially in the first two years of life. Therefore, the aim of this s...

Authors: Aysheshim Kassahun Belew, Bekrie Mohammed Ali, Zegeye Abebe and Berihun Assefa Dachew

The impact of an educational program on recognition, treatment and report of child abuse

Pediatricians play a crucial role in the identification and management of child abuse and neglect (CAN) but they often don’t have a formal specialized training.

Authors: Pietro Ferrara, Antonio Gatto, Nunzia Pia Manganelli, Francesca Ianniello, Maria Elisa Amodeo, Maria Amato, Ida Giardino and Antonio Chiaretti

The impact of the recent AAP changes in palivizumab authorization on RSV-induced bronchiolitis severity and incidence

Following the most recent modification by the American Academy of Pediatrics, based on American studies on RSV epidemiology, the Italian Drug Agency (AIFA) decided to limit the total financial coverage of the ...

Authors: Antonino Capizzi, Michela Silvestri, Andrea Orsi, Renato Cutrera, Giovanni A. Rossi and Oliviero Sacco