Articles

Sex differences in blood pro-oxidant status and platelet activation in children admitted with respiratory syncytial virus bronchiolitis: a pilot study

Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in the pediatric population worldwide and an important cause of death in developing countries. It has been demonstrated that the bala...

Authors: Isabella Tarissi De Jacobis, Rosa Vona, Elisabetta Straface, Lucrezia Gambardella, Giulia Ceglie, Francesca de Gennaro, Ilenia Pontini, Anna Chiara Vittucci, Alessandra Carè, Camilla Cittadini, Alberto Villani and Donatella Pietraforte

Factors associated with the access and continuum of vaccination services among children aged 12–23 months in the emerging regions of Ethiopia: evidence from the 2016 Ethiopian demography and health survey

Child vaccination is an instrument for saving millions of lives. Only one in twenty children has access to childhood vaccination in hard to reach areas in developing countries. Although studies have been done ...

Authors: Ayal Debie and Ayenew Molla Lakew

Novel CDKL5 mutations were found in patients in China: retrospective investigation in cases of CDKL5-related disorders

CDKL5-related disorders (CDD) is an epileptic encephalopathy resulted of gene mutations of CDKL5. This study aimed to explore the development process of CDD and to expand its mutation spectrum.

Authors: Yumei Yan, Dake He, Jing Wu, Ruolin Hou, Kun Sun and Ling Li

Neuroprem: the Neuro-developmental outcome of very low birth weight infants in an Italian region

The survival of preterm babies has increased worldwide, but the risk of neuro-developmental disabilities remains high, which is of concern to both the public and professionals. The early identification of chil...

Authors: Licia Lugli, Marisa Pugliese, Carlotta Plessi, Alberto Berardi, Isotta Guidotti, Gina Ancora, Sara Grandi, Giancarlo Gargano, Silvia Braibanti, Fabrizio Sandri, Silvia Soffritti, Elisa Ballardini, Vittoria Arena, Marcello Stella, Serafina Perrone, Sabrina Moretti…

Recognizable neonatal clinical features of aplasia cutis congenita

Aplasia cutis congenita (ACC), classified in nine groups, is likely to be underreported, since milder isolated lesions in wellbeing newborns could often be undetected, and solitary lesions in the context of po...

Authors: Ingrid Anne Mandy Schierz, Mario Giuffrè, Antonello Del Vecchio, Vincenzo Antona, Giovanni Corsello and Ettore Piro

Association between parity and macrosomia in Shaanxi Province of Northwest China

To explore the relationship between parity and macrosomia and provide the necessary reference for the maternal and children health service.

Authors: Fangliang Lei, Lili Zhang, Yuan Shen, Yaling Zhao, Yijun Kang, Pengfei Qu, Baibing Mi, Shaonong Dang and Hong Yan

Anxiety disorders in acute central nervous system infections

Patients affected by acute central nervous system (ACNS) infectionsmay present different complications, including neuropsychological disorders. Nevertheless, psychopathological impairment has been rarely measu...

Authors: Elena Bozzola, Giulia Spina, Paola Bergonzini, Mauro Bozzola, Massimiliano Raponi and Alberto Villani

Survey of PDA management in very low birth weight infants across Italy

The optimal management of PDA in very low birth weight (VLBW) infants is still controversial. Aim of our study was to investigate the management of PDA in the Italian neonatal intensive care units (NICU).

Authors: Benjamim Ficial, Iuri Corsini, Stefano Fiocchi, Federico Schena, Irma Capolupo, Rosa Maria Cerbo, Manuela Condò, Daniela Doni, Simona La Placa, Salvatore Porzio, Katia Rossi, Sabrina Salvadori and Marilena Savoia

Fetal arrhythmias: prenatal evaluation and intrauterine therapeutics

Fetal arrhythmias are a common phenomenon with rather complicated etiologies. Debates remain regarding prenatal diagnosis and treatment of fetal arrhythmias.

Authors: Shi-Min Yuan and Zhi-Yang Xu

Predict respiratory distress syndrome by umbilical cord blood gas analysis in newborns with reassuring Apgar score

Neonatal acidaemia at birth can increase neonatal morbidity and mortality and it is predictive of neonatal asphyxia. The umbilical blood gas analysis is a valid tool for the evaluation of neonatal acidaemia. H...

Authors: Giuseppe De Bernardo, Rita De Santis, Maurizio Giordano, Desiree Sordino, Giuseppe Buonocore and Serafina Perrone

Neurotoxicity by mercury is not associated with autism spectrum disorders in Spanish children

The pathophysiological etiologies related with the development of Autism Spectrum Disorders (ASD) remain controversial. Different authors have studied neurotoxins such as mercury (Hg) and their relationship wi...

Authors: Fernando Gil-Hernández, Antonio R. Gómez-Fernández, María Josede la Torre-Aguilar, Juan L. Pérez-Navero, Katherine Flores-Rojas, Pilar Martín-Borreguero and Mercedes Gil-Campos

Inflammation, infection, and allergy of upper airways: new insights from national and real-world studies

The upper airways (UA) should be considered as a functional unit. Current functional anatomy divides URT in three, mutually dependent, “junction boxes”: i) the ostio-meatal complex (OMC), ii) the spheno-ethmoi...

Authors: Attilio Varricchio, Ignazio La Mantia, Francesco Paolo Brunese and Giorgio Ciprandi

What we can do? The risk factors for multi-drug resistant infection in pediatric intensive care unit (PICU): a case-control study

The risk factors for multi-drug resistant infection (MDRI) in the pediatric intensive care unit (PICU) remain unclear. It’s necessary to evaluate the epidemiological characteristics and risk factors for MDRI i...

Authors: Zaihua Wang and Zhongfang Xia

The infant gut microbiome as a microbial organ influencing host well-being

Initial establishment of the human gut microbiota is generally believed to occur immediately following birth, involving key gut commensals such as bifidobacteria that are acquired from the mother. The subseque...

Authors: Francesca Turroni, Christian Milani, Sabrina Duranti, Gabriele Andrea Lugli, Sergio Bernasconi, Abelardo Margolles, Francesco Di Pierro, Douwe van Sinderen and Marco Ventura

Acute dacryocystitis with giant lacrimal abscess: a case report

We report a case of a 4-year-old girl with acute dacryocystitis complicated with giant lacrimal abscess who underwent open dacryocystectomy as resolutive surgery.

Authors: Maria Di Cicco, Elisabetta Maria Bellino, Andrea Marabotti, Laura Luti, Diego G. Peroni and Giampiero I. Baroncelli

Analgosedation for diagnostic and interventional procedures: a countrywide survey of pediatric centers in Germany

As more and more diagnostic and interventional options are becoming available for use in pediatric patients, techniques of procedural sedation analgesia (PSA) are being administered in considerably growing num...

Authors: Harald Sauer, Marie Lobenhofer and Hashim Abdul-Khaliq

Effectiveness of a new sensorized videolaryngoscope for retraining on neonatal intubation in simulation environment

In recent years, medical training has significantly increased the use of simulation for teaching and evaluation. The retraining of medical personnel in Italy is entrusted to the program of Continuous Education...

Authors: Alice Covelli, Serena Bardelli, Rosa T. Scaramuzzo, Emilio Sigali, Massimiliano Ciantelli, Marta Del Pistoia, Alessia Longo, Selene Tognarelli, Arianna Menciassi and Armando Cuttano

Characteristics and outcomes in children on long-term mechanical ventilation: the experience of a pediatric tertiary center in Rome

Children with chronic respiratory failure and/or sleep disordered breathing due to a broad range of diseases may require long-term ventilation to be managed at home. Advances in the use of long-term non-invasi...

Authors: Martino Pavone, Elisabetta Verrillo, Alessandro Onofri, Serena Caggiano, Maria Beatrice Chiarini Testa and Renato Cutrera

Pruritus in pediatric patients with atopic dermatitis: a multidisciplinary approach - summary document from an Italian expert group

Given the inadequate overall awareness of the main disease features and treatment modalities of pruritus in pediatric patients with atopic dermatitis, a multidisciplinary Italian expert group met with the majo...

Authors: May El Hachem, Giuseppe Di Mauro, Roberta Rotunno, Simona Giancristoforo, Cristiana De Ranieri, Carla Maria Carlevaris, Maria Carmen Verga and Iride Dello Iacono

Determinants of preterm birth among mothers who gave birth in East Africa: systematic review and meta-analysis

Preterm birth (PTB) can be caused by different factors. The factors can be classified into different categories: socio demographic, obstetric, reproductive health, medical, behavioral and nutritional related. ...

Authors: Tariku Laelago, Tadele Yohannes and Gulima Tsige

Digital screen time and its effect on preschoolers’ behavior in China: results from a cross-sectional study

The aims of the study were to determine the effects of electronic exposure on behaviors of preschoolers, which could provide scientific grounds to the control of digital screen time and usage of electronics.

Authors: Guodong Xie, Qianye Deng, Jing Cao and Qing Chang

High risk of macrosomia in newborns of immigrant mothers

In Italy live about 8.7% immigrants, which contribute to more than 15% of all deliveries taking place in Italy. We aimed to investigate whether newborns from high migratory pressure countries (HMPC) mothers ha...

Authors: Mario De Curtis, Leonardo Villani and Arianna Polo

FMF is not always “fever”: from clinical presentation to “treat to target”

Familial Mediterranean Fever, a monogenic autoinflammatory disease secondary to MEFV gene mutations in the chromosome 16p13, is characterized by recurrent self-limiting attacks of fever, arthritis, aphthous ch...

Authors: Maria Cristina Maggio and Giovanni Corsello

The efficacy of dopamine versus epinephrine for pediatric or neonatal septic shock: a meta-analysis of randomized controlled studies

The efficacy of dopamine versus epinephrine for pediatric or neonatal septic shock remains controversial. We conduct a meta-analysis to explore the influence of dopamine versus epinephrine on shock reversal fo...

Authors: Lingling Wen and Liangyin Xu

Epidemiology and drug allergy results in children investigated in allergy unit of a tertiary-care paediatric hospital setting

Drug Hypersensitivity Reactions (DHRs) are considered adverse effects of medications that resemble allergy symptoms. The reported positive clinical history of pediatric drug reactions is about 10%, however, af...

Authors: A. Piccorossi, G. Liccioli, S. Barni, L. Sarti, M. Giovannini, A. Verrotti, E. Novembre and F. Mori

Blood biomarkers differentiating viral versus bacterial pneumonia aetiology: a literature review

The goal of this literature review is to compare current studies regarding the accuracy of different serum markers in differentiating viral from bacterial pneumonia in the pediatric population with what is emp...

Authors: Jithin Thomas, Aiste Pociute, Rimantas Kevalas, Mantas Malinauskas and Lina Jankauskaite

Isolated auditory neuropathy at birth in congenital cytomegalovirus infection

Congenital cytomegalovirus (cCMV) infection is the most frequent non-genetic cause of sensorineural hearing-loss (SNHL) (i.e., hearing loss due to a cochlear and/or auditory nerve damage). It is widely accepte...

Authors: Fabio Natale, Mario De Curtis, Bianca Bizzarri, Maria Patrizia Orlando, Massimo Ralli, Giuseppina Liuzzi, Barbara Caravale, Francesco Franco, Aurelia Gaeta, Antonella Giancotti, Francesca Yoshie Russo and Rosaria Turchetta

A reflection on the role of genetics in the concept of “epileptic encephalopathy”, as emerged from the most recent ILEA classification of epilepsy

The International League Against Epilepsy (ILAE) has been working to standardize the epilepsy classifications for over a hundred years.

Authors: Angelo Russo and Giuseppe Gobbi

Prevalence and associated factors of anemia among full-term newborn babies at University of Gondar comprehensive specialized hospital, Northwest Ethiopia: a cross-sectional study

Anemia in newborn babies causes asymptomatic to an acute life-threatening event. If untreated, it leads to a delay in brain maturation, tissue hypoxia, and stunted growth. In Sub-Saharan Africa, its burden ran...

Authors: Tegenaw Tiruneh, Elias Shiferaw and Bamlaku Enawgaw

Does virtual reality reduce pain in pediatric patients? A systematic review

Virtual Reality (VR) as a tool for pain reduction is the research topic of several clinical trial for Randomized Controlled Trials despite its wide use in the daily clinical practice for non- pharmacological r...

Authors: Anna Maria Iannicelli, Daniele Vito, Concetta Anna Dodaro, Pasquale De Matteo, Rita Nocerino, Angela Sepe and Valeria Raia

Proton therapy in the most common pediatric non-central nervous system malignancies: an overview of clinical and dosimetric outcomes

Radiation therapy represents an important approach in the therapeutic management of children and adolescents with malignant tumors and its application with modern techniques – including Proton Beam Therapy (PB...

Authors: Angela Sardaro, Roberta Carbonara, Maria Fonte Petruzzelli, Barbara Turi, Marco Moschetta, Arnaldo Scardapane and Amato Antonio Stabile Ianora

A multi-etiological model of childhood obesity: a new biobehavioral perspective for prevention?

Current prevention strategies focusing only around the energy balance model have been found insufficient to tackle the childhood obesity epidemic. Originating from the paper by Baranowski et al., recently publ...

Authors: Giuliana Valerio and Sergio Bernasconi

Early onset retinal dystrophies: clinical clues to diagnosis for pediatricians

Inherited retinal dystrophies are major cause of severe progressive vision loss in children. Early recognition and diagnosis are essential for timely visual rehabilitation during the appropriate stages of the ...

Authors: Agnese Suppiej, Silvia Marino, Maria Eleonora Reffo, Veronica Maritan, Giovanna Vitaliti, Janette Mailo and Raffaele Falsaperla

Two case reports of fetal alcohol syndrome: broadening into the spectrum of cardiac disease to personalize and to improve clinical assessment

Fetal alcohol spectrum disorder (FASD) refers to a broad spectrum of disabilities, in infants and children, resulting from moderate to excessive prenatal alcohol exposure.

Authors: R. Onesimo, C. De Rose, A. B. Delogu, A. Battista, C. Leoni, S. Veltri, G. De Rosa and G. Zampino

Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls

Premature thelarche (PT) is a benevolent ailment affecting young girls. Multiple factors are reported to correlate with this condition, but the mechanisms responsible for the onset of PT have not yet been full...

Authors: Yueqin Xu, Yan Li, Shuang Liang and Guimei Li

Severe congenital RYR1-associated myopathy complicated with atrial tachycardia and sinus node dysfunction: a case report

Cardiac arrhythmias are sometimes encountered in patients with hereditary myopathies and muscular dystrophies. Description of arrhythmias in myopathies and muscular dystrophies is very important, because arrhy...

Authors: Itaru Hayakawa, Yuichi Abe, Hiroshi Ono and Masaya Kubota

The effect of educational intervention based on BASNEF model for reducing internet addiction among female students: a quasi-experimental study

Adolescents and students are encountered with a challenge so-called “internet Addiction”. This issue affects both their physical and mental health, as well as their academic, social, and family performance. Th...

Authors: Batol Gholamian, Hossein Shahnazi and Akbar Hassanzadeh

75th Congress of the Italian Society of Pediatrics

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2019 Congress of the Italian Society of Neonatology

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High expression of miR-222-3p in children with Mycoplasma pneumoniae pneumonia

Mycoplasma pneumoniae is a leading cause of community-acquired pneumonia in children. However, its mechanism of pathogenesis is not fully understood, and microRNAs might play a role. This study aimed to explor...

Authors: Chu Chu, Xiaoli Lei, Yuqin Li, Yali Luo, Ying Ding, Weifang Zhou and Wei Ji

OPG/RANK/RANKL signaling axis in patients with type I diabetes: Associations with parathormone and vitamin D

Type 1 diabetes (T1D) has been associated with a higher fracture risk due to alterations in bone structure and metabolism. On the other hand, the important role of the RANKL/OPG/RANK signaling axis in bone phy...

Authors: Paraskevi Karalazou, Dimitrios Ntelios, Fani Chatzopoulou, Aikaterini Fragou, Maria Taousani, Konstantina Mouzaki, Assimina Galli-Tsinopoulou, Sofia Kouidou and Georgios Tzimagiorgis

PRRT2 gene variant in a child with dysmorphic features, congenital microcephaly, and severe epileptic seizures: genotype-phenotype correlation?

Mutations in Proline-rich Transmembrane Protein 2 (PRRT2) have been primarily associated with individuals presenting with infantile epilepsy, including benign familial infantile epilepsy, benign infantile epileps...

Authors: Piero Pavone, Giovanni. Corsello, Sung Yoon Cho, Xena Giada Pappalardo, Martino Ruggieri, Simona Domenica Marino, Dong Kyu Jin, Silvia Marino and Raffaele Falsaperla

Effectiveness of message-framing intervention on complementary feeding related behaviors among mothers with infants aged 4–8 months: a 3-arm randomized controlled trial

Complementary feeding from the age of 6 months along with breastfeeding is essential for the health of infants. The effect of educational interventions on preventing the early or late onset of complementary fe...

Authors: Ziba Rafieyan-Kopaei, Zohreh Fathian-Dastgerdi, Mohammad Javad Tarrahi and Fereshteh Zamani-Alavijeh

Italian guidelines for the prevention and management of dental trauma in children

Dental trauma is a frequent occurrence in children and adolescent and a correct diagnosis and treatment are essential for a favourable long-term prognosis. The present Guidelines aim to formulate evidence-base...

Authors: Maria Grazia Cagetti, Piero Alessandro Marcoli, Mario Berengo, Piero Cascone, Livio Cordone, Patrizia Defabianis, Osvalda De Giglio, Nicola Esposito, Antonio Federici, Alberto Laino, Alessandra Majorana, Michele Nardone, Vilma Pinchi, Silvia Pizzi, Antonella Polimeni, Maria Grazia Privitera…

Acute pain management in children: a survey of Italian pediatricians

Current guidelines recommend assessing and relieving pain in all children and in all instances; yet, in clinical practice, management is frequently suboptimal. We investigated the attitude of Italian family pe...

Authors: Gian Luigi Marseglia, Maria Alessio, Liviana Da Dalt, Maria Giuliano, Angelo Ravelli and Paola Marchisio

Long-term follow-up until early adulthood in autosomal dominant, complex SPG30 with a novel KIF1A variant: a case report

Pathogenic variants in KIF1A (kinesin family member 1A) gene have been associated with hereditary spastic paraplegia (HSP) type 30 (SPG30), encopassing autosomal dominant and recessive, pure and complicated forms...

Authors: Carlotta Spagnoli, Susanna Rizzi, Grazia Gabriella Salerno, Daniele Frattini and Carlo Fusco

Poor child complementary Feeding Practices in northwest Ethiopia: Finding from the Baseline Survey of Nutrition Project, 2016

Improving infant and young child feeding practices is critical to improved nutrition, health, and development of children. Ethiopia adopted the WHO recommendations of child feeding practices and developed the ...

Authors: Zegeye Abebe, Amare Tariku, Gashaw Andargie Bikes, Molla Mesele Wassie, Kedir Abdela Gonete, Tadesse Awoke, Ejigu Gebeye, Azeb Atnafu Gete, Melkie Edris Yesuf, Yigzaw Kebede, Kassahun Alemu, Abebaw Addis, Esmael Ali Muhammad, Solomon Mekonnen Abebe, Aysheshim Kasahun belew, Melkamu Tamir Hunegnaw…

Trends and determinants of teenage childbearing in Ethiopia: evidence from the 2000 to 2016 demographic and health surveys

Teenage childbearing among adolescents aged 15 to 19 is a common sexual and reproductive health (SRH) issue among young people, particularly in developing countries. It is associated with higher maternal and n...

Authors: Getachew Mullu Kassa, Ayodele O. Arowojolu, Akin-Tunde Ademola Odukogbe and Alemayehu Worku Yalew

Perinatal and newborn care in a two years retrospective study in a first level peripheral hospital in Sicily (Italy)

Two hundred seventy-five thousand maternal deaths, 2.7 million neonatal deaths, and 2.6 million stillbirths have been estimated in 2015 worldwide, almost all in low-income countries (LICs). Moreover, more than...

Authors: Gregorio Serra, Vincenzo Miceli, Salvatore Albano and Giovanni Corsello

Determinants of neonatal sepsis among neonates in the northwest part of Ethiopia: case-control study

Neonatal sepsis is one of the leading causes of neonatal morbidity and mortality. Despite implementing of different preventive interventions, the burden of neonatal sepsis is reporting in different areas of Et...

Authors: Mulunesh Alemu, Mulatu Ayana, Hailemariam Abiy, Biniam Minuye, Wubet Alebachew and Aklilu Endalamaw