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  1. Mutations localized in the Growth Hormone Receptor (GHR) gene are often associated with the pathogenesis of Laron Syndrome, an autosomal recessive hereditary disorder characterized by severe growth retardation...

    Authors: Stefania Moia, Daniele Tessaris, Silvia Einaudi, Luisa de Sanctis, Gianni Bona, Simonetta Bellone and Flavia Prodam
    Citation: Italian Journal of Pediatrics 2017 43:94
  2. Nontuberculous mycobacteria (NTM) are pathogens that commonly affect the paediatric population and its most frequent manifestation is a cervicofacial lymphadenopathy. With the improvement of technologies, new ...

    Authors: A. Azzali, C. Montagnani, M. T. Simonetti, G. Spinelli, M. de Martino and L. Galli
    Citation: Italian Journal of Pediatrics 2017 43:92
  3. The relationship between premature birth and early cognitive function as measured by eye-tracking data remains unexplored. The aim of this study was to determine the effect of prematurity on the development of...

    Authors: Hokyoung Ryu, Garam Han, Jaeran Choi, Hyun-Kyung Park, Mi Jung Kim, Dong-Hyun Ahn and Hyun Ju Lee
    Citation: Italian Journal of Pediatrics 2017 43:90
  4. Upper and lower airways diseases share in part their pathogenic mechanisms and frequently occur simultaneously as “United Airway Disease.” Local treatment with nebulizers delivers anti-symptomatic drugs in eit...

    Authors: Daniela Posa, Antonio Pizzulli, Petra Wagner, Serena Perna, Stephanie Hofmaier, Paolo Maria Matricardi and Susanne Lau
    Citation: Italian Journal of Pediatrics 2017 43:89
  5. Pediatric acute-liver-failure due to acetaminophen (APAP) administration at therapeutic dosage is rare, while viral infections and metabolic defects are the prevalent causes. Yet, as acetaminophen is routinely...

    Authors: Pier Luigi Calvo, Francesco Tandoi, Tobias B. Haak, Andrea Brunati, Michele Pinon, Dominic Dell Olio, Renato Romagnoli and Marco Spada
    Citation: Italian Journal of Pediatrics 2017 43:88
  6. Henoch-Schönlein syndrome is a systemic small-vessel leukocytoclastic vasculitis that usually present with cutaneous, gastrointestinal, articular and renal manifestations. Little is known on liver involvement ...

    Authors: Giulia Rosti, Gregorio P. Milani, Emanuela A. Laicini, Emilio F. Fossali and Mario G. Bianchetti
    Citation: Italian Journal of Pediatrics 2017 43:85
  7. Conduct Disorder (CD) is a psychiatric diagnosis characterized by a repetitive and persistent pattern of behaviour in which the basic rights of others and major age-appropriate social norms or rules are violat...

    Authors: Simone Pisano, Pietro Muratori, Chiara Gorga, Valentina Levantini, Raffaella Iuliano, Gennaro Catone, Giangennaro Coppola, Annarita Milone and Gabriele Masi
    Citation: Italian Journal of Pediatrics 2017 43:84
  8. Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, characterized by impaired social communication and restricted and repetitive behaviours, as well as associated features including intell...

    Authors: Francesca Felicia Operto, Federica Martino, Annalisa Rinaldi, Angelo Cerracchio, Giovanni Salvati, Mariano Orza, Claudia Lembo, Gianvito Panzarino, Claudia Di Paolantonio, Alberto Verrotti, Giovanni Farello and Giangennaro Coppola
    Citation: Italian Journal of Pediatrics 2017 43:83
  9. Newborn hearing screening has to be considered the first step of a program for the identification, diagnosis, treatment and habilitation/rehabilitation of children with hearing impairment.

    Authors: Stefano Berrettini, Paolo Ghirri, Francesco Lazzerini, Giovanni Lenzi and Francesca Forli
    Citation: Italian Journal of Pediatrics 2017 43:82
  10. Growth hormone deficiency (GHD) is a relatively uncommon and heterogeneous endocrine disorder presenting in childhood with short stature. However, during the neonatal period, the metabolic effects of GHD may t...

    Authors: Stefano Stagi, Perla Scalini, Giovanni Farello and Alberto Verrotti
    Citation: Italian Journal of Pediatrics 2017 43:81
  11. This review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several d...

    Authors: Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Silvia Montella and Sergio Bernasconi
    Citation: Italian Journal of Pediatrics 2017 43:80
  12. Rapid development and global spread of multidrug resistant Klebsiella pneumonia (K. pneumoniae) as a major cause of nosocomial infections is really remarkable. The aim of this study was to explore risk factors fo...

    Authors: Sevgen Tanır Basaranoglu, Yasemin Ozsurekci, Kubra Aykac, Eda Karadag Oncel, Asiye Bıcakcigil, Banu Sancak, Ali Bulent Cengiz, Ates Kara and Mehmet Ceyhan
    Citation: Italian Journal of Pediatrics 2017 43:79
  13. The efficacy of low-dose medicine (LDM) in childhood mild/moderate eczema is not known. We conducted a double-blind, two-stage, randomized, placebo-controlled clinical trial, lasting 23 months, to address this...

    Authors: R. Carello, L. Ricottini, V. Miranda, P. Panei, L. Rocchi, R. Arcieri and E. Galli
    Citation: Italian Journal of Pediatrics 2017 43:78
  14. Children with congenital esophageal atresia (EA) and tracheoesophageal fistula (TEF) have chronic respiratory symptoms including recurrent pneumonia, wheezing and persistent cough. The aim of this study is to ...

    Authors: Federica Porcaro, Laura Valfré, Lelia Rotondi Aufiero, Luigi Dall’Oglio, Paola De Angelis, Alberto Villani, Pietro Bagolan, Sergio Bottero and Renato Cutrera
    Citation: Italian Journal of Pediatrics 2017 43:77
  15. The term “humanization” indicates the process by which people try to make something more human and civilized, more in line with what is believed to be the human nature. The humanization of care is an important...

    Authors: Marina Tripodi, Maria Anna Siano, Claudia Mandato, Anna Giulia Elena De Anseris, Paolo Quitadamo, Salvatore Guercio Nuzio, Claudia Viggiano, Francesco Fasolino, Annalisa Bellopede, Maria Annunziata, Grazia Massa, Francesco Maria Pepe, Maria De Chiara, Paolo Siani and Pietro Vajro
    Citation: Italian Journal of Pediatrics 2017 43:76
  16. This study evaluated the validity and reliability of the Italian version of the Non-Communicating Children’s Pain Checklist-Postoperative version (I-NCCPC-PV).

    Authors: C. Zanchi, M. Massaro, G. Ferrara, M. Montico, F. D’Osualdo, R. Rutigliano, A. Taddio, L. Vecchi Brumatti, G. Cozzi and E. Barbi
    Citation: Italian Journal of Pediatrics 2017 43:75
  17. The Mediterranean diet has been for a very long time the basis of food habits all over the countries of the Mediterranean basin, originally founded on rural models and low consumption of meat products and high...

    Authors: Maximilian Fischer, Mauro Stronati and Marcello Lanari
    Citation: Italian Journal of Pediatrics 2017 43:74
  18. Insufficient quantities, frequencies, and inadequate quality of complementary feedings have a negative effect on child health and growth, especially in the first two years of life. Therefore, the aim of this s...

    Authors: Aysheshim Kassahun Belew, Bekrie Mohammed Ali, Zegeye Abebe and Berihun Assefa Dachew
    Citation: Italian Journal of Pediatrics 2017 43:73
  19. Pediatricians play a crucial role in the identification and management of child abuse and neglect (CAN) but they often don’t have a formal specialized training.

    Authors: Pietro Ferrara, Antonio Gatto, Nunzia Pia Manganelli, Francesca Ianniello, Maria Elisa Amodeo, Maria Amato, Ida Giardino and Antonio Chiaretti
    Citation: Italian Journal of Pediatrics 2017 43:72
  20. Following the most recent modification by the American Academy of Pediatrics, based on American studies on RSV epidemiology, the Italian Drug Agency (AIFA) decided to limit the total financial coverage of the ...

    Authors: Antonino Capizzi, Michela Silvestri, Andrea Orsi, Renato Cutrera, Giovanni A. Rossi and Oliviero Sacco
    Citation: Italian Journal of Pediatrics 2017 43:71
  21. The onset of coeliac disease (CD) in the first year of life is uncommon and the diagnosis can be challenging due to the suboptimal sensitivity of tissue transglutaminase antibodies (tTG) at this age and the ma...

    Authors: Michele Arigliani, Francesca Rech Morassutti, Martina Fabris, Paola Melli, Elio Tonutti and Paola Cogo
    Citation: Italian Journal of Pediatrics 2017 43:70
  22. Although the autoimmune polyglandular syndrome type 3 (APS-3) is the commonest APS that may be encountered in pediatric age, last year literature includes only few studies aiming to specifically ascertain the ...

    Authors: Mariella Valenzise, Tommaso Aversa, Angiola Saccomanno, Filippo De Luca and Giuseppina Salzano
    Citation: Italian Journal of Pediatrics 2017 43:69
  23. Pyridoxine dependent epilepsies (PDEs) are rare autosomal recessive disorders with onset in neonatal period. Seizures are typically not responsive to conventional antiepileptic drugs, but they cease after pare...

    Authors: Raffaele Falsaperla and Giovanni Corsello
    Citation: Italian Journal of Pediatrics 2017 43:68
  24. The recognition, follow-up, and early treatment of neonatal jaundice has become more difficult, since the earlier discharge of newborns from hospitals has become common practice. Since intrapartum hypoxic stre...

    Authors: Vincenzo Zanardo, Federico de Luca, Alphonse K. Simbi, Matteo Parotto, Pietro Guerrini and Gianluca Straface
    Citation: Italian Journal of Pediatrics 2017 43:67
  25. Referral for an assessment of tall stature is less common than for short stature. Tall stature is defined as a height more than two standard deviations above the mean for age. The majority of subjects with tal...

    Authors: Cristina Meazza, Chiara Gertosio, Roberta Giacchero, Sara Pagani and Mauro Bozzola
    Citation: Italian Journal of Pediatrics 2017 43:66
  26. Adenylosuccinate lyase (ADSL) deficiency is a defect of purine metabolism affecting purinosome assembly and reducing metabolite fluxes through purine de novo synthesis and purine nucleotide recycling pathways....

    Authors: Marina Macchiaiolo, Sabina Barresi, Francesco Cecconi, Ginevra Zanni, Marcello Niceta, Emanuele Bellacchio, Giacomo Lazzarino, Angela Maria Amorini, Enrico Silvio Bertini, Salvatore Rizza, Benedetta Contardi, Marco Tartaglia and Andrea Bartuli
    Citation: Italian Journal of Pediatrics 2017 43:65
  27. Short stature (SS) is a relatively early sign of poor health. Only in 5% of cases we can explain it through the presence of endocrinological pathologies. Therefore, if SS is present since the first months of l...

    Authors: Paolo Cavarzere, Valentina Bortolotti, Michela Capogna, Margherita Guarnieri, Francesca Lucca, Rossella Gaudino, Stefano Marzini, Claudia Banzato and Franco Antoniazzi
    Citation: Italian Journal of Pediatrics 2017 43:64
  28. Childhood rubella infection is a mild, self-limiting illness. Rubella infection among pregnant women however, is a major public health concern. Depending on gestation age, it may result in fetal death, stillbi...

    Authors: Nikolas A. S. Chotta, Melina Mgongo, Jacqueline G. Uriyo, Sia E. Msuya, Babill Stray-Pedersen and Arne Stray-Pedersen
    Citation: Italian Journal of Pediatrics 2017 43:63
  29. A recent article from Pavone et al. published in the Italian Journal of Pediatrics entitled «Ataxia in children: early recognition and clinical evaluation» made an exhaustive overview of the large spectrum of ...

    Authors: H. Rahmoune, N. Boutrid, M. Amrane, M. C. Chekkour and B. Bioud
    Citation: Italian Journal of Pediatrics 2017 43:62
  30. Recurrent reciprocal 1q21.1 deletions and duplications have been associated with variable phenotypes. Phenotypic features described in association with 1q21.1 microdeletions include developmental delay, cranio...

    Authors: Martina Busè, Helenia C. Cuttaia, Daniela Palazzo, Marcella V. Mazara, Salvatrice A. Lauricella, Michela Malacarne, Mauro Pierluigi, Simona Cavani and Maria Piccione
    Citation: Italian Journal of Pediatrics 2017 43:61
  31. This crossover, randomized, double-blind study (conducted over a 32-week period) was performed to determine, in clinically stable Cystic fibrosis (CF) preschool children: the effects of 7% inhaled hypertonic s...

    Authors: Raffaella Nenna, Fabio Midulla, Caterina Lambiase, Giovanna De Castro, Anna Maria Zicari, Luciana Indinnimeo, Giuseppe Cimino, Patrizia Troiani, Serena Quattrucci and Giancarlo Tancredi
    Citation: Italian Journal of Pediatrics 2017 43:60
  32. The aim of our study is to evaluate if in children with highly positive serology and HLA-DQ2/DQ8 (triple test, TT) and only extra-intestinal symptoms, it is possible to omit performing an intestinal biopsy for...

    Authors: Mauro Bozzola, Cristina Meazza, Chiara Gertosio, Sara Pagani, Daniela Larizza, Valeria Calcaterra, Ombretta Luinetti, Giovanni Farello, Carmine Tinelli and Lorenzo Iughetti
    Citation: Italian Journal of Pediatrics 2017 43:59
  33. Due to the lack of real life clinical and educational studies, “Io e l’Asma” Centre performed this implementation research (IR).

    Authors: Sebastiano Guarnaccia, Gaia Pecorelli, Marina Bianchi, Massimo Cartabia, Gianluigi Casadei, Ada Pluda, Cristina Quecchia, Valeria Gretter and Maurizio Bonati
    Citation: Italian Journal of Pediatrics 2017 43:58
  34. Lipoid congenital adrenal hyperplasia (CAH) (OMIM n. 201710) is the most severe form of congenital adrenal hyperplasia. It is characterized by severe adrenal and gonadal steroidogenesis impairment due to a def...

    Authors: Carla Bizzarri, Elisa Pisaneschi, Mafalda Mucciolo, Stefania Pedicelli, Daniela Galeazzi, Antonio Novelli and Marco Cappa
    Citation: Italian Journal of Pediatrics 2017 43:57
  35. Juvenile idiopathic arthritis (JIA) is a chronic inflammatory arthritis of unknown origin which can be considered an autoimmune disease (AD). The aim of this study is to analyse the presence of two or more aut...

    Authors: Elena Tronconi, Angela Miniaci and Andrea Pession
    Citation: Italian Journal of Pediatrics 2017 43:56
  36. There are limited data on the characterization of medication-related visits (MRVs) to the emergency department (ED) in pediatric patients in Italy. We have estimated the frequency, severity, and classification...

    Authors: Cristiano Rosafio, Serena Paioli, Cinzia Del Giovane, Valentina Cenciarelli, Nilla Viani, Paolo Bertolani and Lorenzo Iughetti
    Citation: Italian Journal of Pediatrics 2017 43:55
  37. Acute cerebellitis (AC) and acute cerebellar ataxia (ACA) are the principal causes of acute cerebellar dysfunction in childhood. Nevertheless. there is no accepted consensus regarding the best management of ch...

    Authors: Laura Lancella, Susanna Esposito, Maria Luisa Galli, Elena Bozzola, Valeria Labalestra, Elena Boccuzzi, Andrzej Krzysztofiak, Laura Cursi, Guido Castelli Gattinara, Nadia Mirante, Danilo Buonsenso, Claudia Tagliabue, Luca Castellazzi, Carlotta Montagnani, Chiara Tersigni, Piero Valentini…
    Citation: Italian Journal of Pediatrics 2017 43:54
  38. Visceral obesity in children increases the risk of developing cardiovascular diseases. To evaluate overweight children, in addition to Body Mass Index (BMI), waist-to-height ratio (WHtR) can be used to predict...

    Authors: Francesca Santomauro, Chiara Lorini, Francesca Pieralli, Giuditta Niccolai, Paola Picciolli, Stefania Vezzosi and Guglielmo Bonaccorsi
    Citation: Italian Journal of Pediatrics 2017 43:53
  39. In Cameroon, sustainable effort needs to be done to reduce the current neonatal mortality rate from 21 deaths per 1000 live births to the global target of fewer than ten deaths per 1000 live births by 2035. We...

    Authors: Paul Koki Ndombo, Quinta Mua Ekei, Joel Noutakdie Tochie, Mazou Ngou Temgoua, Francky Teddy Endomba Angong, Ferdinand Ndom Ntock and Lawrence Mbuagbaw
    Citation: Italian Journal of Pediatrics 2017 43:52
  40. Perampanel is among the latest AEDs approved, indicated for the treatment of partial-onset seizures with or without secondary generalization, and for primary generalized tonic-clonic seizures, in patients aged...

    Authors: Paola De Liso, Romina Moavero, Giangennaro Coppola, Paolo Curatolo, Raffaella Cusmai, Giovambattista De Sarro, Emilio Franzoni, Federico Vigevano and Alberto Verrotti
    Citation: Italian Journal of Pediatrics 2017 43:51
  41. Adolescence is a period of transition to adulthood. Little is known about oral mucosal lesions (OMLs) in teenagers, in which the emergence of new habits, unfamiliar to children, could affect the type of lesions.

    Authors: Francesca Amadori, Elena Bardellini, Giulio Conti and Alessandra Majorana
    Citation: Italian Journal of Pediatrics 2017 43:50
  42. Varicella pneumonia has been studied extensively in adults; it may also affect children and may require hospitalization.

    Authors: Elena Bozzola, Guido Castelli Gattinara, Mauro Bozzola, Nadia Mirante, Marco Masci, Chiara Rossetti, Andrzej Krzystofiak, Luciana Nicolosi, Renato Cutrera, Laura Lancella, Alberto Eugenio Tozzi and Alberto Villani
    Citation: Italian Journal of Pediatrics 2017 43:49
  43. Cancer is the second cause of death in children and its diagnosis can be difficult, due to the presence of vague and non-specific symptoms. The primary care pediatrician is often involved in the diagnostic pro...

    Authors: Marta Minute, Giorgio Cozzi, Chiara Plotti, Giuseppe Montanari, Paolo Pecile, Giulio Andrea Zanazzo, Alessandro Ventura and Egidio Barbi
    Citation: Italian Journal of Pediatrics 2017 43:48
  44. Recently, the prevalence of chromosomal abnormalities (CA) increased as the increasing proportion of mothers with advanced age. We aimed to explore the prevalence of CA in relation to maternal age and perinata...

    Authors: Xiao-Hui Zhang, Li-Qian Qiu, Ying-Hui Ye and Jian Xu
    Citation: Italian Journal of Pediatrics 2017 43:47
  45. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides are rare systemic diseases that usually occur in adulthood. They comprise granulomatosis with polyangiitis (GPA, Wegener’s), microscopic poly...

    Authors: Marta Calatroni, Elena Oliva, Davide Gianfreda, Gina Gregorini, Marco Allinovi, Giuseppe A. Ramirez, Enrica P. Bozzolo, Sara Monti, Claudia Bracaglia, Giulia Marucci, Monica Bodria, Renato A. Sinico, Federico Pieruzzi, Gabriella Moroni, Serena Pastore, Giacomo Emmi…
    Citation: Italian Journal of Pediatrics 2017 43:46

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