Category | Definition | Examples |
---|---|---|
1 | Underlying conditions with strong genetic basis | Â |
1A | Single-gene or chromosomal | Hemophilia, thalassemia, ataxia telangiectasia, Down's syndrome, cystic fibrosis |
1B | Multifactorial/polygenic | Hydrocephaly, congenital hydronephrosis |
1C | Heterogeneous causes, often of a genetic basis | Psychomotor retardation, megalocephaly, microcephaly, mental retardation |
2 | Birth defects without known genetic basis | Â |
2A | Malformation of unknown etiology | - |
2B | Teratogenic disorders | - |
3 | Acquired disorders with genetic predisposition | Diabetes mellitus, asthma |