Table 4 Comparison between disease severity score, response to colchicine therapy, and number of attacks per year in the three study groups
Item | Hetero-zygous (n=40) | Homo-zygous (n=20) | Gene-ve (n=10) | P-value | |
|---|---|---|---|---|---|
Disease severity score, n (%) | Mild | 9 (22.5) | 0 (0.0) | 0 (0.0) | 0.01* |
Moderate | 26 (65.5) | 14 (70) | 10 (100) | ||
Severe | 5 (12.5) | 6 (30) | 0 (0.0) | ||
Response to colchicine, n (%) | Complete | 13 (32.5) | 1 (5.0) | 2 (20) | 0.09 |
Incomplete | 25 (62.5) | 19 (95.0) | 8 (80) | ||
No response | 2 (5) | 0 (0.0) | 0 (0.0) | ||
Colchicine dose to control attacks, mean ± SD | 1.26 ± 0.36 | 1.47 ± 0.34 | 1.40 ± 0.21 | 0.04* | |
Number of attacks per year, mean ± SD | Before treatment (range) | 23.70 ± 11.47 (10–72) | 24.40 ± 6.95 (12–36) | 25 ± 9.76 (16–48) | 0.6 |
After treatment (range) | 4.80 ± 5.81 (0–24) | 3.95 ± 2.50 (0–10) | 4.5 ± 4.22 (0–12) | 0.9 | |