Table 1 Clinical symptoms (days with symptoms) evaluated in Group A and in Group B at T1, T2, and T3

Nasal obstruction

3.3 ± 1.7

6 ± 4.4

8.3 ± 5.2

< 0.001

3.7 ± 1.7

1.2 ± 1.4

1.6 ± 2.2

< 0.001

Rhinorrhea

5 ± 1.5

8.5 ± 6.1

12.1 ± 5.7

< 0.001

4.7 ± 1.6

3 ± 2.9

2.8 ± 3

< 0.001

Sneezing

0.7 ± 1

1.6 ± 2.3

1.3 ± 1.7

< 0.001

0.8 ± 1.3

0.3 ± 1.1

0.3 ± 1.1

< 0.001

Cough

3.5 ± 3.3

3.5 ± 3

3.6 ± 3.2

N.S.

3.5 ± 3.2

1.9 ± 2.7

2.2 ± 3.1

0.002

Fever

1.5 ± 1.7

1.2 ± 2.5

1.2 ± 1.5

N.S.

0.3 ± 0.7

1.8 ± 2.4

0.2 ± 0.5

<0.001

Medications

9.3 ± 0.7

5.5 ± 3

5.9 ± 2.8

<0.05

9.1 ± 0.6

1.3 ± 1.8

2.5 ± 2.9

<0.001

Medical visits

0.5 ± 0.7

1.5 ± 1

1.5 ± 1.2

<0.001

0.4 ± 0.6

0.6 ± 0.9

0.8 ± 1.4

<0.001

Absences at school

1.4 ± 2

2.3 ± 2.1

2.3 ± 2

<0.005

0.4 ± 0.7

1 ± 1

1.3 ± 1.8

<0.001