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Table 3 Fat-soluble vitamin supplementation in the cholestatic infant

From: Italian guidelines for the management and treatment of neonatal cholestasis

Vitamin

Preparation

Dosage

Adverse effects

Vitamin A

Aquasol A

5000-25000 U/day per os

Hepatotoxicity, Hypercalcemia,

Vitamin D

Cholecalciferol

800-5000 U/day PO per os

Hypercalcemia, Nephrocalcinosis

Vitamin E

D-α-tocopheryl polyethylene glycol 1,000 succinate

15-25 U/kg/day PO per os

Potentiation of vitamin K deficiency coagulopathy

Vitamin K

Phytomenadione

2.5–5 mg twice a week to every day per os

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