Symptoms/signs | IgE-mediated FA | Mixed form (IgE/non-IgE-mediated FA) | Non-IgE-mediated FA |
---|---|---|---|
Gastrointestinal | - Nausea/vomiting - Diarrhea - Abdominal pain - Itching of the oral cavity - Tongue edema | - Nausea/vomiting - Sialorrhea - Diarrhea - Colic - Constipation - Abdominal pain - Dysphagia - Dyspepsia - Retrosternal pyrosis - Loss of appetite - Hematochezia/ melaena - Malabsorption - Poor growth/weight loss - Food impaction | - Nausea/vomiting - Sialorrhea - Diarrhea - Colic - Constipation - Abdominal pain - Dysphagia - Dyspepsia - Retrosternal pyrosis - Loss of appetite - Hematochezia/ melaena - Malabsorption - Poor growth/weight loss |
Respiratory | - Itchy nose/nasal congestion - Rhinorrhea - Sneezing - Wheezing/coughing/ dyspnea - Laryngeal stridor - Thoracic constriction - Conjunctival tearing, itching and hyperemia | - Interstitial lung disease | |
Cutaneous | - Wheals - Edema of the subcutaneous tissues - Rapid onset erythema or rash - Pruritus | - Eczematous lesions | |
Others | - Hypotension - Pallor - Lethargy - Shock | - Hypotension - Pallor - Lethargy - Shock | |
Clinical entities | IgE-mediated FA | Mixed form (IgE/non-IgE-mediated FA) | Non-IgE-mediated FA |
- Anaphylaxis - Food-dependent exercise- induced anaphylaxis - Oral allergy syndrome - Acute repetitive vomiting and/or abdominal pain and/or diarrhea - Asthma and oculorhinitis - Urticaria and angioedema | - Atopic dermatitis - Eosinophilic disorders of the gastrointestinal tract | - Food Protein-Induced Enterocolitis Syndrome (FPIES) - Food Protein-Induced Allergic Proctocolitis (FPIAP) - Food Protein- induced Enteropathy (FPE) - Food induced motility disorders (FPIMD) (constipation, colic, gastroesophageal reflux disease) - Heiner Syndrome |