Dilemmas and options for COVID-19 vaccination in children

Table 3 Vaccine effectiveness against omicron variant in children

Variant	Years	Vaccination status	Type of vaccination	Detection time interval	Vaccine effectiveness (95% CI)			Reference
Variant	Years	Vaccination status	Type of vaccination	Detection time interval	Symptomatic infection	Hospital admission	Admission ICU	Reference
Omicron	5–11	First dose	BNT162b2	14–27 days	18.0%	NP		[55]
		First dose		≥ 14 days	9.0%			[56]
		Second dose		≥ 7 days	49.0%			[56]
				14–30 days	60.1%			[57]
				30–90 days	28.9%			[57]
				≥ 7 days	NP	82.7%	NP	[58]
				≥ 14 days	NP	68.0%	NP	[59]
				7–21 days	48.0%	NP		[55]
				51 days (median)	NP	48.0%	NP	[60]
				0–14 days	38.7%	NP		[61]
				43–84 days	21.2%	NP		[61]
Omicron	12–18	First dose	BNT162b2	122 days (median)	26.1%	NP		[62]
		First dose	CoronaVac	31 days (median)	21.5%
		Second dose	BNT162b2	189 days (median)	54.9%
			CoronaVac	64 days (median)	55.0%
			BNT162b2	2–22 weeks	NP	43.0%	NP	[59]
				23–44 weeks		38.0%
Pre-Omicron				2–22 weeks		93.0%
				23–44 weeks		92.0%
				7–21 days	93.0%	NP		[63]
				≥ 14 days	NP	94.0%	98.0%	[64]
				62 days (median)	93.0%	NP		[65]
Omicron		Third dose	BNT162b2	31 days (median)	86.8%	NP		[62]
Omicron		Third dose	CoronaVac	67 days (median)	92.0%	NP		[62]

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