Table 2 Comparison of demographic and clinical characteristics between patients with IVIG resistant and non-resistant KD.
Variable | Training set (N = 461) | Test set (N = 197) | ||||
|---|---|---|---|---|---|---|
IVIG-responsive (N = 417) | IVIG-resistant (N = 44) | P-value | IVIG-responsive (N = 161) | IVIG-resistant (N = 36) | P-value | |
Month_old | ||||||
Mean (SD) | 25.5 (19.3) | 30.3 (28.6) | 0.278 | 27.8 (22.2) | 35.1 (29.3) | 0.167 |
Sex | ||||||
Female | 154 (36.9%) | 15 (34.1%) | 0.836 | 60 (37.3%) | 14 (38.9%) | 1.000 |
Male | 263 (63.1%) | 29 (65.9%) | 101 (62.7%) | 22 (61.1%) | ||
WBC (×10^9) | ||||||
Mean (SD) | 16.7 (6.65) | 14.6 (5.19) | 0.013 | 15.5 (5.11) | 14.0 (4.94) | 0.122 |
N/L ratio | ||||||
Mean (SD) | 3.77 (3.27) | 6.50 (5.89) | 0.004 | 3.62 (2.89) | 5.55 (6.10) | 0.071 |
HCT (%) | ||||||
Mean (SD) | 34.4 (3.37) | 34.0 (3.73) | 0.573 | 34.5 (2.99) | 33.3 (4.20) | 0.106 |
PLT (×10^9) | ||||||
Mean (SD) | 373 (132) | 322 (135) | 0.022 | 331 (109) | 317 (141) | 0.571 |
Na+ (mmol/L) | ||||||
Mean (SD) | 136 (2.68) | 135 (3.01) | 0.003 | 136 (2.87) | 136 (3.61) | 0.853 |
ALB (g/L) | ||||||
Mean (SD) | 36.8 (4.18) | 35.3 (4.30) | 0.026 | 37.5 (4.72) | 35.7 (4.61) | 0.041 |
TBIL (μmol/L) | ||||||
Mean (SD) | 11.1 (10.9) | 20.8 (20.7) | 0.004 | 10.3 (9.96) | 23.5 (48.5) | 0.111 |
AST/ALT ratio | ||||||
Mean (SD) | 1.93 (3.61) | 1.38 (1.43) | 0.051 | 1.64 (1.22) | 1.74 (1.44) | 0.724 |
GGT (IU/L) | ||||||
Mean (SD) | 69.9 (79.8) | 120 (124) | 0.011 | 74.3 (84.6) | 94.8 (102) | 0.269 |
LDH (U/L) | ||||||
Mean (SD) | 317 (113) | 345 (102) | 0.093 | 336 (134) | 381 (158) | 0.121 |
CK-MB (U/L) | ||||||
Mean (SD) | 17.6 (15.2) | 17.6 (9.70) | 0.965 | 19.8 (14.5) | 22.0 (17.9) | 0.496 |
BUN (mmol/L) | ||||||
Mean (SD) | 2.99 (2.71) | 3.87 (2.63) | 0.041 | 3.10 (1.19) | 3.25 (1.01) | 0.430 |
Cr (μmol/L) | ||||||
Mean (SD) | 20.3 (9.41) | 25.3 (22.5) | 0.156 | 20.1 (7.40) | 25.2 (13.7) | 0.038 |
CRP (mg/L) | ||||||
Mean (SD) | 84.5 (55.8) | 107 (61.1) | 0.025 | 65.2 (46.6) | 80.8 (44.8) | 0.067 |
PCT (ng/ml) | ||||||
Mean (SD) | 2.37 (9.00) | 7.67 (11.1) | 0.004 | 4.19 (16.2) | 5.73 (15.8) | 0.602 |
ESR (mm/h) | ||||||
Mean (SD) | 68.3 (27.0) | 66.8 (24.7) | 0.708 | 58.7 (27.7) | 58.9 (34.3) | 0.970 |
DDR (mg/L) | ||||||
Mean (SD) | 1.47 (2.08) | 2.27 (2.50) | 0.047 | 1.48 (2.14) | 2.21 (2.17) | 0.075 |
fever_day_before_treatment | ||||||
Mean (SD) | 6.57 (2.12) | 6.00 (2.51) | 0.15 | 6.16 (1.66) | 6.08 (2.66) | 0.866 |
Coronary artery lesion | ||||||
No | 349 (83.7%) | 34 (77.3%) | 0.385 | 148 (91.9%) | 32 (88.9%) | 0.796 |
Yes | 68 (16.3%) | 10 (22.7%) | 13 (8.1%) | 4 (11.1%) | ||