Serum levels of PDGF-CC as a potential biomarker for the diagnosis of Kawasaki disease

Table 2 Predictive ability of biomarkers to distinguish KD from FC.

	PP	AUC	95%CI	cut-off value	Se(%)	Sp(%)	+LR	-LR	Youden Index
WBC	0.0028*	0.720	0.605–0.817	9.87	89.83	52.94	1.91	0.19	0.428
PLT	0.7478	0.523	0.406–0.639	313.00	49.15	70.59	1.67	0.72	0.197
CRP	< 0.0001*	0.790	0.680–0.875	36.00	67.24	88.24	5.72	0.37	0.555
PDGF-CC	< 0.0001*	0.796	0.688–0.880	2.22	74.58	76.47	3.17	0.33	0.511
PDGF-CC + WBC	< 0.0001*	0.813	0.707–0.893	0.74	74.58	76.47	3.17	0.33	0.502
PDGF-CC + PLT	< 0.0001*	0.797	0.689–0.880	0.78	66.10	88.24	5.62	0.38	0.543
PDGF-CC + CRP	< 0.0001*	0.892	0.800-0.952	0.70	84.48	82.35	4.79	0.19	0.668
PDGF-CC + WBC + CRP	< 0.0001*	0.900	0.808–0.957	0.62	86.21	82.35	4.89	0.17	0.686

Note: KD, Kawasaki disease; FC, Febrile control; WBC, white blood cell counts; PLT, platelet counts; CRP, C-reactive protein; AUC Area under the curve; Se, sensitivity; Sp, specificity; +LR, positive likelihood ratio; -LR, negative likelihood ratio; *P < 0.05

ISSN: 1824-7288