Fig. 1

CDC Clinical Criteria for MIS-A The CDC Clinical Criteria for MIS-A are as follows: Subjective fever or documented fever (≥ 38.0 °C) for ≥ 24 h prior to hospitalization or within the first three days of hospitalization and at least three of the following clinical criteria occurring prior to hospitalization or within the first three days of hospitalization. At least one must be a primary clinical criterion. Primary clinical criteria include severe cardiac illness, which encompasses myocarditis, pericarditis, coronary artery dilatation/aneurysm, or new-onset right or left ventricular dysfunction (LVEF < 50%), 2nd/3rd degree A-V block, or ventricular tachycardia (Note: cardiac arrest alone does not meet this criterion), as well as the presence of rash AND non-purulent conjunctivitis. Secondary clinical criteria consist of new-onset neurologic signs and symptoms, such as encephalopathy in a patient without prior cognitive impairment, seizures, meningeal signs, or peripheral neuropathy, shock or hypotension not attributable to medical therapy, abdominal pain, vomiting, or diarrhea, and thrombocytopenia