Fig. 2

CDC Clinical Criteria for MIS-C The CDC Clinical Criteria for MIS-C are as follows: In the absence of a more likely alternative diagnosis, MIS-C is characterized by subjective or documented fever (temperature ≥ 38.0 °C), clinical severity requiring hospitalization or resulting in death, evidence of systemic inflammation indicated by C-reactive protein ≥ 3.0 mg/dL (30 mg/L), and new onset manifestations in at least two of the following categories. These categories include cardiac involvement, which can be identified by left ventricular ejection fraction < 55%, coronary artery dilatation, aneurysm, or ectasia, or elevated troponin levels above the laboratory’s normal range or indicated as elevated in a clinical note. Mucocutaneous involvement may manifest as a rash, inflammation of the oral mucosa, conjunctivitis, or conjunctival injection, as well as extremity findings like erythema or edema of the hands or feet. Shock is also considered. Gastrointestinal involvement is indicated by symptoms such as abdominal pain, vomiting, or diarrhea. Hematologic involvement is characterized by a platelet count < 150,000 cells/µL or an absolute lymphocyte count (ALC) < 1,000 cells/µL