Table 1 Medication treatment for MIS-C

Immunoglobulins

Immunomodulatory: IVIG considered first-line therapy.

IVIG [19, 51]

Single dose at 2 gm/kg based on ideal body weight

Glucocorticoids

Immunomodulatory: Glucocorticoids should be used as adjunctive therapy with severe disease or refractory disease.

Methylprednisolone [19, 52]

1–2 mg/kg/day, typically in two doses

Dexamethasone [19, 53]

0.15–0.4 mg/kg/day, PO or IV

Prednisone [28]

1–2 mg/kg/day, PO

Monoclonal antibodies

Immunomodulatory: Lack of response to the treatment.

Anakinra [19, 29]

Starting dosing at 2–3 mg/kg q12h SC (total of 4–6 mg/kg/day, max: 100 mg/dose)

Tocilizumab [19]

Single IV dose (< 30 kg: 12 mg/kg IV; ≥ 30 kg: 8 mg/kg IV; max: 800 mg)

Infliximab [19, 54]

5–10 mg/kg, 1 dose

Anticoagulants

Anticoagulant thromboprophylaxis

Enoxaparin [19, 55]

1 mg/kg/day

Warfarin [19]

Therapeutic anticoagulation with warfarin

Antiplatelet agents

Antiplatelet therapy

Low-dose aspirin [19, 56]

3–5 mg/kg/day, max: 81 mg/day