Table 4 Therapeutic options for GABHS pharyngitis recommended by American Hearth Association and American Academy of Pediatrics AAP [13, 4].
From: Update on the management of acute pharyngitis in children
Drug | Dose | Duration |
|---|---|---|
Penicillins | ||
Penicillin V (oral) | • Children <27 kg: 400 000 U (250 mg) 2 to 3 times daily ; • Children >27 kg, adolescents, and adults: 800 000 (500 mg) 2 to 3 times daily | 10 days |
Amoxicillin (oral) | 50 mg/kg once daily (maximum 1 g) | 10 days |
Benzathin Penicillin G (intramuscular) | • Children <27 kg: 600 000 U (375 mg); • Children >27 kg, adolescents, and adults: 1 200 000 U (750 mg) | Once |
For individuals allergic to penicillin | ||
Narrow-spectrum cephalosporin (cephalexin, cefadroxil) (oral)* | Variable | 10 days |
Clindamycin (oral) | 20 mg/kg per day divided in 3 doses (maximum 1.8 g/d) | 10 days |
Azithromycin (oral) | 12 mg/kg once daily (maximum 500 mg) | 5 days |
Clarithromycin (oral) | 15 mg/kg per day divided BID (maximum 250 mg BID) | 10 days |