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Table 11 Drugs used for the treatment of hypertension in children and adolescents, which on the basis of their long half-life are administered once-a-day

From: Focus on prevention, diagnosis and treatment of hypertension in children and adolescents

  Recommended Daily Dose (mg)
  Body Weight (kg)
Class Drug name 10-25 25-40 >40
Renin-Angiotensin-Aldosterone     
System Blockers     
AT1-receptor Blockers Candesartan 4-8 8-16 16-32
  Irbesartan 37-75 75-150 150-300
  Losartan 12-25 (25)-100 (50)-100
  Olmesartan (2.5)-10 5-20 20-40
  Valsartan 20-40 40-80 80-160
ACE -Inhibitors Benazepril 2.5-5.0 5.0-10 10-20[40]
  Fosinopril 1.3-2.5 2.5-10 5.0-20[40]
  Lisinopril 2.5-10 5.0-20 10.30[40]
  Quinapril 2.5-5.0 5.0-10 10-20[40]
  Ramipril 1.3-2.5 2.5-10 5.0-20
Beta-Blockers Atenolol 12-25 25-100 100-200
  Bisoprolol 1.2-2.5 2.5-5.0 5.0-10
  Metoprolol 10-25 25-100 100-200
Calcium Antagonists Amlodipine 2.5-5.0 5-10 10-20
Thiazide Diuretics Chlorthalidone 6-12 12-25 25-50
  Hydrochlorothiazide 6-12 12-25 25-50
  1. Retard formulations are unsuitable as they are often badly absorbed in children (and when split in two the prolonged effect of these formulations disappears).