Table 1 Main demographic, clinical and echocardiographic findings of preterm neonates before treatment with paracetamol

Demographic and clinical features

 N.

8

 Body weight at birth, g

724 ± 173

 Gestational age at birth, weeks

26 ± 2

 Caesarian section, n (%)

6 (75.0)

 Male, n (%)

6 (75.0)

 Apgar at 5 minutes

5 ± 1

 Resuscitation at birth, n (%)

8 (100)

 Body weight at enrollment, g

743.7 ± 167.6

 Age at enrollment, h

66 ± 28

Contraindication to COX-inhibitors

 Oliguria, n (%)

4 (50.0)

 Thrombocytopenia, n (%)

2 (25.0)

 Intraventricular hemorrhage, n (%)

1 (12.5)

 Blood in gastric aspirates, n (%)

1 (12.5)

 Hyperbilirubinemia requiring phototherapy, n (%)

4 (50.0)

 Hyperbilirubinemia requiring exchange transfusion, n (%)

0 (0.0)

Echocardiographic findings

 Diameter of the ductus ≥ 1.5 mm, n (%)

3 (37.5)

 Left-atrium-to-aortic-root ratio > 1.6, n (%)

6 (75.0)

 Unrestrictive pulsatile transductal flow, n (%)

1 (12.5)

 Reverse flow in the descending aorta, n (%)

2 (25.0)