Table 3 Genotype and allele frequencies of the rs2682826 polymorphism of the NOS1 gene in RDS and the control groups among different gestational ages and birth weights
Genotype/Allele | Control group (n = 227) | RDS group (n = 189) | P value | OR (95% CI) |
|---|---|---|---|---|
Gestational age | ||||
26w ≤ GA < 33 W | n = 107 | n = 93 | ||
GG | 45 (42.1) | 41 (44.1) | ||
GT | 51 (47.7) | 36 (38.7) | 0.405 | 0.775 (0.425–1.413) |
TT | 11 (10.3) | 16 (17.2) | 0.294 | 1.596 (0.664–3.836) |
G allele | 141 (65.9) | 118 (63.4) | ||
T allele | 73 (34.1) | 68 (36.6) | 0.609 | 1.113 (0.738–1.679) |
33w ≤ GA < 37 W | n = 120 | n = 96 | ||
GG | 54 (45.0) | 45 (46.9) | ||
GT | 56 (46.7) | 39 (40.6) | 0.536 | 0.836 (0.473–1.476) |
TT | 10 (8.3) | 12 (12.5) | 0.440 | 1.440 (0.569–3.642) |
G allele | 164 (68.3) | 129 (67.2) | ||
T allele | 76 (31.7) | 63 (32.8) | 0.800 | 1.054 (0.702–1.581) |
Birth weight | ||||
BW < 1.5 | n = 63 | n = 44 | ||
GG | 25 (39.7) | 21 (47.7) | ||
GT | 33 (52.4) | 19 (43.2) | 0.360 | 0.685 (0.305–1.540) |
TT | 5 (7.9) | 4 (9.1) | 1.000 | 0.952 (0.226–4.008) |
G allele | 83 (65.9) | 61 (69.3) | ||
T allele | 43 (34.1) | 27 (30.7) | 0.597 | 0.854 (0.477–1.532) |
1.5 < BW < 2.5 | n = 86 | n = 70 | ||
GG | 36 (41.9) | 31 (44.3) | ||
GT | 42 (48.8) | 32 (45.7) | 0.718 | 0.885 (0.455–1.720) |
TT | 8 (9.3) | 7 (10.0) | 0.978 | 1.106 (0.331–3.122) |
G allele | 114 (66.3) | 94 (67.1) | ||
T allele | 58 (33.7) | 46 (32.9) | 0.872 | 0.962 (0.599–1.545) |
BW > 2.5 | n = 85 | n = 75 | ||
GG | 38 (44.7) | 34 (45.3) | ||
GT | 32 (37.6) | 24 (32.0) | 0.623 | 0.838 (0.415–1.693) |
TT | 15 (17.6) | 17 (22.7) | 0.578 | 1.267 (0.550–2.918) |
G allele | 108 (63.5) | 92 (61.3) | ||
T allele | 62 (36.5) | 58 (38.7) | 0.686 | 1.098 (0.698–1.728) |