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Table 3 Genotype and allele frequencies of the rs2682826 polymorphism of the NOS1 gene in RDS and the control groups among different gestational ages and birth weights

From: Analysis of nitric oxide synthase gene polymorphisms in neonatal respiratory distress syndrome among the Chinese Han population

Genotype/Allele Control group (n = 227) RDS group (n = 189) P value OR (95% CI)
Gestational age     
  26w ≤ GA < 33 W n = 107 n = 93   
  GG 45 (42.1) 41 (44.1)   
  GT 51 (47.7) 36 (38.7) 0.405 0.775 (0.425–1.413)
  TT 11 (10.3) 16 (17.2) 0.294 1.596 (0.664–3.836)
  G allele 141 (65.9) 118 (63.4)   
  T allele 73 (34.1) 68 (36.6) 0.609 1.113 (0.738–1.679)
  33w ≤ GA < 37 W n = 120 n = 96   
  GG 54 (45.0) 45 (46.9)   
  GT 56 (46.7) 39 (40.6) 0.536 0.836 (0.473–1.476)
  TT 10 (8.3) 12 (12.5) 0.440 1.440 (0.569–3.642)
  G allele 164 (68.3) 129 (67.2)   
  T allele 76 (31.7) 63 (32.8) 0.800 1.054 (0.702–1.581)
Birth weight     
  BW < 1.5 n = 63 n = 44   
  GG 25 (39.7) 21 (47.7)   
  GT 33 (52.4) 19 (43.2) 0.360 0.685 (0.305–1.540)
  TT 5 (7.9) 4 (9.1) 1.000 0.952 (0.226–4.008)
  G allele 83 (65.9) 61 (69.3)   
  T allele 43 (34.1) 27 (30.7) 0.597 0.854 (0.477–1.532)
  1.5 < BW < 2.5 n = 86 n = 70   
  GG 36 (41.9) 31 (44.3)   
  GT 42 (48.8) 32 (45.7) 0.718 0.885 (0.455–1.720)
  TT 8 (9.3) 7 (10.0) 0.978 1.106 (0.331–3.122)
  G allele 114 (66.3) 94 (67.1)   
  T allele 58 (33.7) 46 (32.9) 0.872 0.962 (0.599–1.545)
  BW > 2.5 n = 85 n = 75   
  GG 38 (44.7) 34 (45.3)   
  GT 32 (37.6) 24 (32.0) 0.623 0.838 (0.415–1.693)
  TT 15 (17.6) 17 (22.7) 0.578 1.267 (0.550–2.918)
  G allele 108 (63.5) 92 (61.3)   
  T allele 62 (36.5) 58 (38.7) 0.686 1.098 (0.698–1.728)