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Table 7 One-way (univariate) sensitivity analysis

From: Analysis of the cost-effectiveness of surfactant treatment (Curosurf®) in respiratory distress syndrome therapy in preterm infants: early treatment compared to late treatment

Parameter

"Early" treatment

"Late" treatment

Difference (€)

C/E analysis result

Base case

   

Dominant

MV and/or death < 7 days, (%)*

21

63

-42

 

Average cost per treated patient (€)

4,901.70

4,960.07

- 58.37

 

Variation in Mechanical Ventilation cost

    

  - plus 15% compared to base case (€)

4,918.03

4,998.95

- 80.93

Dominant

  - minus 15% compared to base case (€)

4,885.37

4,921.18

- 35.81

Dominant

  - plus 30% compared to base case (€)

4,934.35

5,037.84

-103.49

Dominant

  - minus 30% compared to base case (€)

4,869.05

4,882.29

- 13.25

Dominant

Variation in NCPAP cost

    

  - plus 15% compared to base case (€)

5,551.85

5,618.43

- 133.57

Dominant

  - minus 15% compared to base case (€)

4,251.55

4,301.70

- 50.16

Dominant

  - plus 30% compared to base case (€)

6,202.01

6,276.79

- 74.78

Dominant

  - minus 30% compared to base case (€)

3,601.39

3,643.34

- 41.95

Dominant

% ET patients with MV

    

  - plus 15% compared to base case (€)

4,918.03

4,960.07

- 42.04

Dominant

  - plus 30% compared to base case (€)

4,934.35

4,960.07

- 25.71

Dominant

  - plus 50% compared to base case (€)

4,956.12

4,960.07

- 3.94

Dominant

ET patient days in MV

    

  - plus 15% compared to base case (€)

4,914.39

4,960.07

- 45.68

Dominant

  - plus 30% compared to base case (€)

4,927.08

4,960.07

- 32.99

Dominant

  - plus 50% compared to base case (€)

4,944.00

4,960.07

- 16.07

Dominant

  1. *For calculation of the cost-effectiveness ratio the reciprocal of the estimated given efficacy by the Verder et al. study was considered[12], i.e., the percentage of patients that do not undergo MV and/or death within seven days of birth equal to 79% for the ET group and 37% for the LT group was considered.