The ever-expanding conundrum of primary osteoporosis: aetiopathogenesis, diagnosis, and treatment

Table 2 Causes of osteogenesis imperfecta, involved genes, location, inheritance, and gene products

Osteogenesis imperfecta	OMIM	Inheritance	Gene	Location	Gene product
Type I	166200	AD	COL1A1	17q21.33	Collagen, Type I, Alpha-1
Type II	166210	AD	COL1A1	17q21.33	Collagen, Type I, Alpha-1
	166210	AD	COL1A2	7q21.3	Collagen, Type I, Alpha-2
Type III	259420	AD	COL1A1	17q21.33	Collagen, Type I, Alpha-1
	259420	AD	COL1A2	7q21.3	Collagen, Type I, Alpha-2
Type IV	166220	AD	COL1A2	7q21.3	Collagen, Type I, Alpha-2
	166220	AD	COL1A1	17q21.33	Collagen, Type I, Alpha-1
Type V	610967	AD	IFITM5	11p15.5	Interferon-induced transmembrane protein-5
Type VI	613982	AR	SERPINF1	17p13.3	Serpin peptidase inhibitor
	610682	AR	CRTAP	3p22.3	Cartilage-associated protein
	610915	AR	LEPRE1	1P34.2	Leucine- and Proline-Enriched Proteoglycan 1
Type IX	259440	AR	PPIP	15q22.31	Peptidyl-prolyl isomerase b
Type X	613848	AR	SERPINH1	11q13.5	Serpin peptidase inhibitor, Clade H, Member 1
Type XI	610968	AR	FKBP10	17q21.2	FK506-binding protein 10
Type XII	613849	AR	SP7	12q13.13	Transcription factor Sp7
Type XIII	614856	AR	BMP1	8q21.3	Bone morphogenetic protein 1
Type XIV	615066	AR	TMEN38B	9q31.2	Transmembrane Protein 38B
Type XV	615220	AR	WNT1	12q13.12	Wingless-type MMTV Integration Site Family, Member 1

Note. This table lists only the most frequent types according to the recent literature.

ISSN: 1824-7288