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Table 3 Causes of Ehlers-Danlos syndrome, genes involved, location, inheritance, and gene product

From: The ever-expanding conundrum of primary osteoporosis: aetiopathogenesis, diagnosis, and treatment

Ehlers-Danlos syndrome OMIM Inheritance Gene Location Gene product
  Type I 130000 AD COL5A2 2q32.2 Collagen, Type -V, Alpha-2
130000 AD COL5A1 9q34.3 Collagen, Type -V, Alpha-1
130000 AD COL1A1 17q21.33 Collagen, Type -I, Alpha-1
  Type II 130010 AD COL5A1 9q34.3 Collagen, Type -V, Alpha-1
  Type III 130020 AD TNXB 6p21.33 Tenascin XB
  Type IV 130050 AD COL3A1 2q32.2 Collagen, Type III, Alpha-1
  Type V 305200 - - - -
  Type VI 225400 Ad/ar PLOD1 1p36.22 Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase
  Type VIIA 130060 AD COL1A1 17q21.33 Collagen, Type I, Alpha-1
  Type VIIB 130060 AD COL1A2 7q21.3 Collagen, Type I, Alpha-2
  Type VIIC 225410 AR ADANTS2 5q35.2 Procollagen I N-Proteinase
  Type VIII 130080 AR - 12p13 -
  1. Note: This table lists only the most frequent types according to the recent literature.