Steroid-sensitive nephrotic syndrome in children: triggers of relapse and evolving hypotheses on pathogenesis

Table 2 Relapse rates and cumulative prednisolone dosage at 12-month follow-up

	Intervention group	Control group	Rate	p
	n = 49	n = 46	Difference
Infection-associated	0.7 ± 0.3 (0.6,1.1)	1.4 ± 0.5 (1.2,1.9)	0.7 (0.3,1.1)	<0.01
Relapses (episodes/patient per year)^a
Total relapses (episodes/patient per year)^a	0.9 ± 0.4 (0.7, 1.2)	1.8 ± 0.5 (1.4, 2.2)	0.9 (0.4, 1.4)	<0.0001
			Mean
			Difference
Cumulative prednisolone (mg/kg per year)^b	120 ± 32 (105,131)	138 ± 22 (112,144)	16 (−26, 38)	0.3

^aRelapse rates are the mean incidence density rates ± SD (95% confidence interval).
^bThe data are expressed as the means ± SD (95% confidence interval).
-Adapted and reproduced with permission from Gulati et al. Clin J Am Soc Nephrol 6:63–69, January, 2011.

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