Table 1 Potentially deleterious effects of high Cl--content secondary to administration of large volume of 0.9 % saline addressed in the literature
From: The great fluid debate: saline or so-called “balanced” salt solutions?
• Hyperchloremic metabolic acidosis (traditionally called dilution acidosis) | |
• Acute kidney injury with reduced urine output and increase in interstitial fluid volume | |
• Hyperkalemia (K+ mobilized from the intracellular space) | |
• Damaged endothelial surface layer with increased vascular permeability and stiffness | |
• Increase in proinflammatory mediators and tendency to infections | |
• Detrimental effect on coagulation with tendency to blood loss | |
• Detrimental gastrointestinal perfusion and function | |
• Possible uneasiness at the bedside resulting in unnecessary administration of more fluids |