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Table 1 Criteria indicative for therapeutic hypothermia

From: The effects of selective head cooling versus whole-body cooling on some neural and inflammatory biomarkers: a randomized controlled pilot study

Criteria A
 1. Apgar score <5 at 10 min of age
 2. Continued need for ventilation 10 min after birth
 3. pH <7.0 or base deficit < −16 in blood gases within 1 h of birth
Criteria B
 Moderate to severe encephalopathy, consisting of altered state of consciousness (as shown by lethargy, stupor, or coma) and >1 of the following:
  1. Hypotonia
  2. Abnormal reflexes, including oculomotor or papillary abnormalities
  3. Absent or weak sucking reflex
  4. Clinical seizures
Criteria C
 Amplitude-integrated electroencephalography (aEEG) records (30-min)
  1. Moderately abnormal aEEG background activity
  2. Severely abnormal aEEG background activity
  3. Seizure activity