Table 1 Criteria indicative for therapeutic hypothermia

Criteria A

 1. Apgar score <5 at 10 min of age

 2. Continued need for ventilation 10 min after birth

 3. pH <7.0 or base deficit < −16 in blood gases within 1 h of birth

Criteria B

 Moderate to severe encephalopathy, consisting of altered state of consciousness (as shown by lethargy, stupor, or coma) and >1 of the following:

  1. Hypotonia

  2. Abnormal reflexes, including oculomotor or papillary abnormalities

  3. Absent or weak sucking reflex

  4. Clinical seizures

Criteria C

 Amplitude-integrated electroencephalography (aEEG) records (30-min)

  1. Moderately abnormal aEEG background activity

  2. Severely abnormal aEEG background activity

  3. Seizure activity