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Table 1 Characteristic of children with Down syndrome (DS) and the reference population (REF)

From: Prevalence, prenatal screening and neonatal features in children with Down syndrome: a registry- based national study

  2009. 2010. 2011. 2012.
DS REF DS REF DS REF DS REF
N = 33 N = 44673 N = 19 N = 43400 N = 26 N = 41306 N = 42 N = 41761
Birth weight (g, mean) 2906.7a 3409.8 2954.2a 3428.6 2954.2a 3389.4 2763.2a 3396.7
Birth length (cm, mean) 47.4a 50.2 46.1a 50.3 47.5a 50.1 46.9a 50.1
Gestational age (weeks, mean)b 36.7a 39.1 36.7a 39.2 37.8a 39.0 37.0a 39.0
Apgar ≥ 6 after 5 minb 22 (66.7 %)a 39694 (99.2 %) 12 (63.1 %)a 37728 (98.9 %) 20 (76.9 %)a 36079 (99.0 %) 30 (71.4 %)a 36859 (99.3 %)
Intervention on delivery 6 (18.2 %) 8913 (19.9 %) 7 (36.8 %) 9224 (21.3 %) 7 (26.9 %) 7213 (17.5 %) 19 (45.2 %) 8845 (21.2 %)
Parity 1 6 (18.2 %) 15002 (33.6 %) 8 (42.1 %) 14776 (34.0 %) 8 (30.8 %) 14083 (34.1 %) 12 (28.6 %) 14359 (34.4 %)
Parity 2 6 (18.2 %) 5643 (12.6 %) 1 (5.3 %) 5289 (12.2 %) 5 (19.2 %) 5015 (12.1 %) 5 (11.9 %) 5116 (12.3 %)
Parity 3 3 (9.1 %) 1597 (3.6 %) 1 (5.3 %) 1525 (3.5 %) 3 (11.6 %) 1469 (3.6 %) 3 (7.1 %) 1483 (3.6 %))
Parity ≥4 3 (9.1 %) 1017 (2.3 %) 0 (0.0 %) 1044 (2.4 %) 1 (3.8 %) 1015 (2.5 %) 1 (2.4 %) 1024 (2.5 %)
Parity 0 15 (45.4 %) 21414 (47.9 %) 9 (47.4 %) 20766 (47.8 %) 9 (34.6 %) 19724 (47.8 %) 21 (50.0 %) 19779 (47.4 %)
Mother age (years, mean) 32.7a 29.0 31.8a 28.2 32.0a 30.0 33.2a 29.2
Breast feeding 21 (63.6 %)a 42676 (95.5 %) 11 (57.9 %)a 40812 (94.0 %) 19 (73.1 %)a 39413 (95.4 %) 31 (73.80 %)a 40268 (96.4 %)
Perinatal mortality (on 10000) 5 (1515.2) 343 (76.8) 3 (1578.9) 323 (74.4) 2 (769.2) 268 (64.9) 4 (952.4) 240 (57.5)
Fetal mortality (on 10000) 4 (1212.1) 191 (42.7) 1 (526.3) 210 (48.4) 1 (384.6) 158 (38.3) 3 (714.3) 162 (38.8)
Early neonatal mortality (on 10000 newborns) 1 (344.8) 152 (34.2) 2 (1111.1) 111 (25.7) 1 (400.0) 102 (24.8) 1 (256.4) 77 (18.5)
  1. aSignificant differences (P < 0.05) between DS regarding referent population for each year (birth weight, birth length, gestational age and mother age were assessed with independent t-test; other differences with chi-square test)
  2. bFor Apgar scoring total N for referent population were 40022 (2009), 38118 (2010), 36444 (2011) and 37119 (2012)