Recombinant growth hormone therapy in a girl with costello syndrome: a 4-year observation

Table 1 Symptoms in consecutive months of life

Child’s age	Clinical symptoms
	Lack of appetite	Vomiting, spitting up	Dysphagia	Esophagitis	Underweight	Hepatomegaly	Neurological abnormalities	Delayed speech development	Loose skin	Coarse facial features	Arrhythmias	Hypertrophic cardiomyopathy	Excessive joint laxity	Achilles tendon contractures	Short stature
1 month									^a			+^b
2−3 months	+	+	+	+		+			+
4−6 months	+	+	+	+	+		+^d		+		+^c		+
7−9 months	+	+	+	+	+		+^d	+	+				+
11−24 months	+	+	+	+	+			+	+	+			+		+
24−36 months					+			+	+	+			+		+
>3 years of life								+	+	+			+	+	+

ISSN: 1824-7288