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Table 1 Symptoms in consecutive months of life

From: Recombinant growth hormone therapy in a girl with costello syndrome: a 4-year observation

Child’s age Clinical symptoms
  Lack of appetite Vomiting, spitting up Dysphagia Esophagitis Underweight Hepatomegaly Neurological abnormalities Delayed speech development Loose skin Coarse facial features Arrhythmias Hypertrophic cardiomyopathy Excessive joint laxity Achilles tendon contractures Short stature
1 month          a    +b    
2−3 months + + + +   +    +       
4−6 months + + + + +   +d   +   +c   +   
7−9 months + + + + +   +d + +     +   
11−24 months + + + + +    + + +    +   +
24−36 months      +    + + +    +   +
>3 years of life         + + +    + + +
  1. Key
  2. aEdema
  3. bSuspicion, later studies did not confirm hypertrophic cardiomyopathy
  4. cTransient
  5. dReduced muscle tone, periodic spasticity of the lower limbs