Fig. 1

Child’s facial features and principal biochemical exams modifications. Panels A-D: child’s previous pictures and picture at diagnosis (before starting the therapy) demonstrating a modification of the facial features due to hypothyroidism. Panels E-H: child’s pictures after the treatment start. The child’s face changed again, returning to the child’s face before the onset of hypothyroidism. Panel L and N: ungual dystrophy and its recovery. Panel M: alopecia. Panels O-S: principal biochemical values at diagnosis and after the treatment start. From the beginning of the treatment, a gradual normalization of Hb, CPK, Creatinine, fT4 and TSH values was evident. The timeline indicates the moments in which the serum dosages were made, comparing them with the gradual changes in the facial habitus of the child