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Table 2 Summary of evidences for Pharmacological Treatment of FGIDs

From: Pharmacological interventions on early functional gastrointestinal disorders

FGID Results
Infant regurgitation Alginate may be considered if symptoms are severe, associated with marked distress, and other non-pharmacological measures failed
Infant rumination syndrome No evidence of pharmacological treatment
Cyclic vomiting syndrome No RCTs. Retrospective studies showed benefit using cyproheptadine, propanolol and pizotifen in prophylaxis. During the acute phase of vomiting, intravenous infusion of glucoelctrolytic solutions, ondasetron, lorazepam and acid inhibitors are suggested.
Infant colic No evidence of pharmacological treatment
Functional diarrhea No evidence of pharmacological treatment
Infant dyschezia No evidence of pharmacological treatment
Constipation Lactulose is recommended for infants younger than 6 months of age, whereas in older infants and in children PEG with or without electrolytes represents the first-line therapy for both fecal disimpaction and maintenance.