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Table 4 Associations of TNFa, PRKCA and ADRB2 genotypes with Current Wheezers and the mediating role of HDL-C levels

From: Shared genetic variants between serum levels of high-density lipoprotein cholesterol and wheezing in a cohort of children from Cyprus

SNP (genotype) Model 1 ORa (95 % CI) p-value Model 2 ORb (95 % CI) p- value Model 3 ORc (95 % CI) p- value
ADRB2 rs1800888       
 CT 1.00   1.00   1.00  
 CC 2.18 (0.76–6.29) 0.148 2.15 (0.75–6.21) 0.156 1.98 (0.68–5.79) 0.212
TNFa rs3093664       
 GG 1.00   1.00   1.00  
 AG 5.02 (1.13–22.25) 0.034 4.92 (1.11–21.80) 0.036 3.43 (0.76–15.53) 0.110
 AA 3.39 (0.79–14.49) 0.100 3.35 (0.78–14.33) 0.104 2.44 (0.56–10.58) 0.239
PRKCA rs9892651       
 TT 1.00   1.00   1.00  
 CT 1.25 (0.85–1.84) 0.255 1.26 (0.85–1.85) 0.250 1.17 (0.79–1.73) 0.448
 CC 1.623 (0.98–2.68) 0.058 1.63 (0.99–2.69) 0.056 1.52 (0.91–2.53) 0.110
  1. aModel 1 adjusted for age & sex
  2. bModel 2 adjusted for age, sex & BMI z scores
  3. cModel 3 adjusted for age, sex, BMI z scores & HDL-C levels