Table 4 Associations of TNFa, PRKCA and ADRB2 genotypes with Current Wheezers and the mediating role of HDL-C levels
SNP (genotype) | Model 1 ORa (95Â % CI) | p-value | Model 2 ORb (95Â % CI) | p- value | Model 3 ORc (95Â % CI) | p- value |
|---|---|---|---|---|---|---|
ADRB2 rs1800888 | Â | Â | Â | Â | Â | Â |
 CT | 1.00 |  | 1.00 |  | 1.00 |  |
 CC | 2.18 (0.76–6.29) | 0.148 | 2.15 (0.75–6.21) | 0.156 | 1.98 (0.68–5.79) | 0.212 |
TNFa rs3093664 | Â | Â | Â | Â | Â | Â |
 GG | 1.00 |  | 1.00 |  | 1.00 |  |
 AG | 5.02 (1.13–22.25) | 0.034 | 4.92 (1.11–21.80) | 0.036 | 3.43 (0.76–15.53) | 0.110 |
 AA | 3.39 (0.79–14.49) | 0.100 | 3.35 (0.78–14.33) | 0.104 | 2.44 (0.56–10.58) | 0.239 |
PRKCA rs9892651 | Â | Â | Â | Â | Â | Â |
 TT | 1.00 |  | 1.00 |  | 1.00 |  |
 CT | 1.25 (0.85–1.84) | 0.255 | 1.26 (0.85–1.85) | 0.250 | 1.17 (0.79–1.73) | 0.448 |
 CC | 1.623 (0.98–2.68) | 0.058 | 1.63 (0.99–2.69) | 0.056 | 1.52 (0.91–2.53) | 0.110 |