Can biological components predict short-term evolution in Autism Spectrum Disorders? A proof-of-concept study

Table 1 Biological, clinical, and family history variables included in the analysis, which eventually identified the four subgroups used in the study (from Sacco et al. 2010)

Developmental and clinical variables	Biological variables	Family history variables
Age at non-verbal language development	History of allergies	Pregnancy duration
Age at verbal language development	History of regression	History of obstetric complications or recurrent spontaneous abortions in the mother
Level of verbal language development	History of obstetric complications at or immediately after birth	History of any allergic and/or immune disease in the family
Age at walking	History of any infectious disease at autism onset	History of tumors in the family
Age at acquisition of bladder control at night	History of sleep disorders	History of any neurological or psychiatric disorders in the family
Age at first social smile	Presence of muscle hypotonia at neurological examination
Motor, verbal or vocal stereotypies	EEG pattern (evaluated at T0)
Self-aggressive or self-injurious behaviour	Pain sensitivity (reported by parents)
Hyperactivity

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