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Table 2 Pros and cons of pQCT for bone health evaluation in developmental age [180]

From: Peripheral quantitative computed tomography (pQCT) for the assessment of bone strength in most of bone affecting conditions in developmental age: a review

Advantages of pQCT

Disadvantages of pQCT

Measure of bone geometry : marrow and cortical Cross-Sectional Area (CSA), Cortical Thickness (CoTh), periosteal and endosteal circumference.

Evaluation of only appendicular bone with low turnover (radius and tibia).

Distinct obtainment of Trabecular and Cortical BMD values

Low spatial resolution.

Good accurancy and precision.

Exact repositioning of the extremity required in follow-up.

Low radiation dose (≈3 μSv per scan), especially important in children.

Scarce data available about pQCT –based fracture risk.

Functional evaluation of pediatric bone diseases, through muscle and fat measures and biomechanical bone parameters provided.