Fig. 2
![Fig. 2](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs13052-017-0410-8/MediaObjects/13052_2017_410_Fig2_HTML.gif)
Methodological quality of the articles included in the present revision according to the QUADAS-2 tool [12]. a Risk of bias and applicability concerns graph: review authors’ judgements about each domain presented as percentages across included specific-IgE studies Review Manager (RevMan) [Computer program]. Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014. b Risk of bias and applicability concerns graph: review authors’ judgements about each domain presented as percentages across included SPT studies. Review Manager (RevMan) [Computer program]. Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014