Table 2 Mutations and resistance pattern
From: Dolutegravir-based anti-retroviral therapy is effective and safe in HIV–infected paediatric patients
Patient | Reverse transcriptase | Protease | ||
|---|---|---|---|---|
Mutations | Resistance | Mutations | Resistance | |
1 | M41 L, V75IMV, F77 L, T215D, E44A/D, V118I, D67N, M184 V | 3TC (LR), ABC (IR), ZDV (HR), D4T (HR), DDI (HR), FTC (LR), TDF (IR), EFV (S), ETR (S), NVP (S), RPV (S) | A71AV, N88DN, D30N | LPV (S), ATV (LR), DRV (S), IDV (S), FPV (S), NFV (IR), SQV (LR), TPV (S) |
2 | K103 N, P225H, M184 V | 3TC (HR), ABC (LR), ZDV (S), D4T (S), DDI (LR), FTC (HR), TDF (S), EFV (HR), ETR (S), NVP (HR), RPV (S) | K20I, A71AT, L89 V, M36I | LPV (S), ATV (S), DRV (S), IDV (S), FPV (S), NFV (LR), SQV (S), TPV (S) |
3 | Not available | Not available | Not available | Not available |
4 | M184 V, G190A | 3TC (HR), ABC (S), ZDV (S), D4T (S), DDI (S), FTC (HR), TDF (S), EFV (IR), NVP (HR) | L10 V, L63P | LPV (S), ATV (S), DRV (S), IDV (S), FPV (S), NFV (S), SQV (S), TPV (S) |
5 | D67N, K101P, K103 N/S, M184 V, G190A, T215Y | 3TC (HR), ABC (IR), ZDV (IR), D4T (IR), DDI (S), FTC (HR), TDF (S), EFV (HR), NVP (HR) | L10F, I13V, K20I, M36I, M46I, Q58E, L63P, H69K, L76 V, I84V, L89I | LPV (IR), ATV (HR), DRV (S), IDV (IR), FPV (HR), NFV (HR), SQV (IR), TPV (IR) |
6 | Not available | Not available | Not available | Not available |