Table 5 Genotypes of the FTO and LEPR variants in patients with the most common LEs; statistical analysis using Fisher’s exact test (NS – not significant)
FTO gene polymorphism rs9939609 (c.28-23,525 T > A) | ||||
LEs | Genotypes Number of cases with LEs / without LEs | Statistical significance (Fisher’s exact test) | ||
TT | TA | AA | ||
Endocrine disturbances | 7/29 | 11/47 | 7/24 | NS |
Hepatitis | 9/27 | 4/54 | 10/21 | p = 0.004 (AA vs. TT); p = 0.03 (AA vs. AT + TT) |
Psychological abnormalities | 2/34 | 8/50 | 1/30 | NS |
Leptin receptor gene (LEPR) polymorphism rs1137100 (K109R; c.326A > G) | ||||
LEs | Genotypes Number of cases with LEs / without LEs | Statistical significance (Fisher’s exact test) | ||
AA | AG | GG | ||
Endocrine disturbances | 9/49 | 14/45 | 2/6 | NS |
Hepatitis | 12/46 | 9/50 | 2/6 | NS |
Psychological abnormalities | 8/50 | 4/55 | 0/8 | NS |
Leptin receptor gene (LEPR) polymorphism rs1137101 (Q223R; c.668A > G) | ||||
LEs | Genotypes Number of cases with LEs / without LEs | Statistical significance (Fisher’s exact test) | ||
AA | AG | GG | ||
Endocrine disturbances | 16/53 | 5/23 | 4/24 | NS |
Hepatitis | 11/58 | 6/22 | 6/22 | NS |
Psychological abnormalities | 11/58 | 1/27 | 0/28 | p = 0.03 (AA vs. GG) |
Leptin receptor gene (LEPR) polymorphism rs1805094 (K656 N; c.1968G > C) | ||||
LEs | Genotypes Number of cases with LEs / without LEs | Statistical significance (Fisher’s exact test) | ||
GG | GC | CC | ||
Endocrine disturbances | 6/19 | 19/80 | 0/1 | NS |
Hepatitis | 3/22 | 19/80 | 1/0 | NS |
Psychological abnormalities | 2/23 | 10/89 | 0/1 | NS |