Table 2 Clinical characteristics of patients with initial ETV6-RUNX1-positive ALL
Clinical features | number (ratio) | range | median |
|---|---|---|---|
Gender | |||
male | 48(62.3%) | ||
female | 29(37.7%) | ||
Age (years) | 4 | ||
<1 | 0 | ||
1~ 6 | 59(76.6%) | ||
6~ 10 | 12(15.6%) | ||
>10 | 6(7.8%) | ||
WBC(×109/L) | 11 | ||
<20 | 54(70.1%) | 0.4~ 20 | 5.3 |
20~ 50 | 12(15.6%) | 21~ 48 | 33 |
>50 | 11(14.3%) | 55~ 145 | 75 |
PLT(×109/L) | 48 | ||
<100 | 52(67.5%) | 3~ 95 | 36.5 |
≥ 100 | 25(32.5%) | 102~ 457 | 150 |
Immunophenotype | |||
Common-B | 60(77.9%) | ||
Pre-B | 17(22.1%) | ||
Chromosome | 66(85.7%) | ||
hyperdiploidy | 7(10.6%) | ||
hypodiploidy | 6(9.1%) | ||
normal karyotype | 45(68.2%) | ||
pseudodiploidy | 22(33.3%) | ||
ETV6-RUNX1/ABL (%) | 77(100%) | 20.9~ 789.1 | 240.78 |
MRD on Day + 33(%) | 71(92.2%) | ||
≥ 10−2 | 6(8.5%) | 1.7~ 14.5 | 2.25 |
10−2~ 10−3 | 7(9.9%) | 0.1~ 0.67 | 0.2 |
10−3~ 10−4 | 14(19.7%) | 0.019~ 0.091 | 0.03 |
10−4~ 10−5 | 2(2.8%) | 0.0049~ 0.0062 | 0.0055 |
negative | 42(59.2%) | 0 | 0 |