Table 1 Age of onset of the main signs and symptoms in different mucopolysaccharidosis (MPS) types

Hydrops foetalis [10, 19]

Birth

I, IVA, VII

Diarrhea [6, 13]

First months

I, II, III

Hernias [11, 12]

Birth or first months

Almost all MPS

Upper respiratory hypersecretion/Infections [6, 13]

First months –1 Year

I, II, III, VI

Heart valve [8, 13, 18, 21]

< 1 year

I

< 5 yrs

II, VI, VII

Coarse face [11, 15]

9-18 m

I,II, VI

2-4 yrs

II, III

Corneal clouding [11]

< 15 m

I, VI

Liver/spleen enlargement [6, 13]

< 1 year

I,II,III, VI

Cognitive delay [2, 12]

< 18 months

I

2-3 years

II,III

Macrocrania [1, 6, 21]

Birth – 1 year

I, II, III, IV, VI, VII

Skeletal dysplasia [2, 15]

< 1 year

II, IV

2- 4 yrs

I, VI

Growth impairment [13]

12 – 18 m

I

<3 yrs

IV, VI

Behavioural anomalies [1, 6]

< 2 yrs

I

2-4 years

II, III

Sleep disturbances [6, 13]

First year

I,II,III, VI