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Table 4 Provocation test to NSAID in children

From: SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children

  Drug Dose (mg/kg) Subsequent doses Interval between doses (h) Maximum dose (mg/kg) Mean reaction time (h)
Kidon MI, 2007 [91] ASA 2,5 Same dose 1 10 1–4
Ibuprofen 2,5 Same dose 1 10 2–4
Paracetamol 5 Same dose 1 20 2–4
Kidon M, 2018 [27]   1/10–1/4 of the maximum dose Incremental doses 1 - Paracetamol 15–20 mg/kg/dose,
-Ibuprofen 10 mg/kg/dose,
-ASA 15–20 mg/kg/dose
2–4
Additional doses of the drug can be necessary on the following days at home
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