Table 4 Provocation test to NSAID in children
Drug | Dose (mg/kg) | Subsequent doses | Interval between doses (h) | Maximum dose (mg/kg) | Mean reaction time (h) | |
|---|---|---|---|---|---|---|
Kidon MI, 2007 [91] | ASA | 2,5 | Same dose | 1 | 10 | 1–4 |
Ibuprofen | 2,5 | Same dose | 1 | 10 | 2–4 | |
Paracetamol | 5 | Same dose | 1 | 20 | 2–4 | |
Kidon M, 2018 [27] | 1/10–1/4 of the maximum dose | Incremental doses | 1 | - Paracetamol 15–20 mg/kg/dose, -Ibuprofen 10 mg/kg/dose, -ASA 15–20 mg/kg/dose | 2–4 Additional doses of the drug can be necessary on the following days at home |