Table 2 PFS and OS by risk factors of 268 stage 4 s neuroblastoma patients

 1979–1984

26 (9.7)

8 (30.8)

69.2 (47.8–83.3)

0.217#

6 (23.1)

76.9 (55.7–88.9)

0.041#

 1985–1999

116 (43.3)

43 (37.1)

62.3 (52.7–70.5)

26 (22.4)

77.2 (68.3–83.9)

 2000–2013

126 (47)

32 (25.4)

72.4 (62.4–80.1)

14 (11.1)

89.7 (82.9–93.9)

 Male

156 (58.2)

52 (33.3)

65.4 (57.1–72.5)

0.24

34 (21.8)

78.5 (71.1–84.2)

0.018

 Female

112 (41.8)

31 (27.7)

72.1 (62.7–79.5)

12 (10.7)

88.5 (80.3–93.4)

 0–29

60 (22.4)

23 (38.3)

59.8 (45.7–71.4)

0.033#

17 (28.3)

73.0 (59.7–82.5)

0.067#

 30–59

40 (14.9)

14 (35.0)

65.0 (48.2–77.6)

8 (20.0)

80.0 (64.0–89.5)

 60–89

37 (13.8)

9 (24.3)

75.0 (57.5–86.1)

6 (16.2)

83.8 (67.4–92.4)

 90–119

40 (14.9)

15 (18.1)

61.6 (44.6–74.8)

7 (17.5)

81.0 (63.5–90.6)

  ≥ 120

91 (33.9)

22 (26.5)

75.5 (65.2–83.1)

8 (8.8)

91.0 (82.7–95.4)

 0–29

60 (22.4)

23 (38.3)

59.8 (45.7–71.4)

0.058

17 (28.3)

73.0 (59.7–82.5)

0.006

 30–365

208 (77.6)

60 (28.8)

70.7 (64.0–76.4)

29 (19.9)

85.5 (79.6–89.7)

 None

17 (6.3)

1 (5.9)

94.1 (65.0–99.2)

< 0.001#

0

100

< 0.001#

 Yes, minor

51 (19.0)

9 (17.7)

82.4 (68.8–90.4)

2 (3.9)

96.0 (84.9–99.0)

 Yes, major

200 (74.6)

73 (36.5)

62.4 (55.1–68.8)

44 (22.0)

77.9 (71.3–83.2)

 None

82 (30.6)

15 (18.3)

81.7 (71.5–88.5)

0.004

4 (4.9)

94.7 (86.5–98.0)

< 0.001

 Yes

186 (69.4)

68 (36.6)

62.2 (54.6–68.9)

42 (22.6)

77.4 (70.6–82.9)

 None

216 (80.6)

57 (26.4)

73.4 (66.9–78.8)

< 0.001

24 (11.1)

88.4 (83.1–92.2)

< 0.001

 Yes

52 (19.4)

26 (50)

47.1 (32.5–60.3)

22 (42.3)

59.5 (44.9–71.4)

 None

234 (87.3)

72 (30.8)

68.8 (62.4–74.4)

0.714

36 (15.4)

84.0 (78.4–88.2)

0.032

 Yes

34 (12.7)

11 (32.4)

64.5 (44.3–78.9)

10 (29.4)

73.5 (55.3–85.3)

 No major symptoms

68 (25.4)

10 (14.7)

85.3 (74.4–91.8)

< 0.001

2 (2.9)

97.0 (88.6–99.2)

< 0.001

 Hepatomegaly ± Organ dysfunction

146 (54.5)

47 (32.2)

67.4 (59.0–74.4)

22 (15.1)

84.4 (77.2–89.5)

 Dyspnea ± Organ dysfunction

12 (4.5)

5 (41.7)

58.3 (27.0–80.1)

2 (16.7)

83.3 (48.2–95.6)

 Hepatomegaly + Dyspnea (±Organ dysfunction)

40 (14.9)

21 (52.5)

43.0 (26.3–58.7)

20 (50)

52.4 (36.0–66.4)

 Organ dysfunction only

2 (0.8)

0

100

0

100

 None

234 (87.3)

77 (32.9)

66.1 (59.5–71.9)

0.078

45 (19.2)

80.6 (74.7–85.2)

0.023

 Yes

34 (12.7)

6 (17.6)

82.4 (64.9–91.7)

1 (2.9)

97.1 (80.9–99.6)

 None

257 (95.9)

80 (31.1)

68.0 (61.8–73.4)

0.797

44 (17.1)

82.8 (77.5–87.0)

0.896

 Yes

11 (4.1)

3 (27.3)

72.7 (37.1–90.3)

2 (18.2)

77.9 (35.4–94.2)

 No

226 (84.3)

64 (28.3)

70.7 (64.1–76.3)

0.029

36 (15.9)

83.9 (78.2–88.3)

0.255

 Yes

42 (15.7)

19 (45.2)

54.8 (38.7–68.3)

10 (23.8)

75.9 (59.7–86.2)

 None

256 (95.5)

77 (30.1)

69.1 (62.9–74.5)

0.148

45 (17.6)

82.6 (77.3–86.8)

0.404

 Yes

12 (4.5)

6 (50)

50.0 (20.9–73.6)

1 (8.3)

75.0 (12.8–96.1)

 Adrenal

175 (65.3)

59 (33.7)

65.8 (58.2–72.3)

0.609

33 (18.8)

80.4 (73.5–85.8)

0.489

 Abdomen

49 (18.3)

11 (22.5)

75.0 (58.7–85.6)

7 (14.3)

87.8 (74.8–94.3)

 Thorax

22 (8.2)

7 (31.8)

68.2 (44.6–83.4)

1 (4.5)

95.5 (71.9–99.4)

 Neck

9 (3.4)

3 (33.3)

66.7 (28.2–87.8)

2 (22.2)

71.1 (23.3–92.3)

 Not detected

13 (4.9)

3 (23.1)

76.9 (44.2–91.9)

3 (23.1)

76.9 (44.2–91.9)

 No

246 (91.8)

76 (30.9)

68.9 (62.7–74.4)

0.944

45 (18.3)

81.5 (75.8–85.9)

0.112

 Yes

22 (8.2)

7 (31.8)

68.2 (44.6–83.4)

1 (4.5)

95.5 (71.9–99.4)

 No

38 (14.2)

7 (18.4)

81.6 (65.2–90.8)

0.084

0

100

0.004

 Yes

230 (85.8)

76 (33)

65.9 (59.3–71.8)

46 (20)

79.8 (73.7–84.5)

 No

157 (58.6)

49 (31.2)

68.3 (60.3–75.0)

0.753

28 (17.8)

81.9 (74.9–87.2)

0.643

 Yes

111 (41.4)

34 (30.6)

68.1 (58.2–76.2)

18 (16.2)

83.6 (74.6–89.6)

 Normal

59 (26.6)

16 (27.1)

72.4 (59.0–82.1)

0.381

5 (8.5)

91.5 (80.8–96.4)

0.13

 Elevated

163 (73.4)

53 (32.5)

66.7 (58.7–73.5)

27 (16.6)

83.9 (77.2–88.7)

 Normal

18 (16.1)

4 (22.2)

77.8 (51.1–91.0)

0.253

2 (11.1)

88.9 (62.4–97.1)

0.846

 Elevated

94 (83.9)

33 (35.1)

64.0 (53.0–73.0)

12 (12.8)

88.3 (79.9–93.3)

 Normal

131 (57.7)

33 (25.2)

74.6 (66.2–81.2)

0.055

14 (10.7)

89.1 (82.3–93.4)

0.031

 Elevated

96 (42.3)

35 (36.5)

60.9 (49.6–70.4)

20 (20.8)

78.8 (68.1–86.2)

 Normal

116 (60.1)

34 (29.3)

70.5 (61.2–77.9)

0.859

15 (12.9)

87.0 (79.4–92.0)

0.425

 Elevated

77 (39.9)

22 (28.6)

70.0 (58.1–79.1)

13 (16.9)

82.8 (72.1–89.6)

 Normal

168 (91.8)

53 (31.5)

67.1 (59.1–73.9)

0.673

21 (12.5)

86.8 (79.9–91.5)

0.021

 Amplified

15 (8.2)

6 (40)

60.0 (31.8–79.7)

5 (33.3)

66.7 (37.5–84.6)

 Normal

110 (79.7)

31 (28.2)

71.3 (61.7–78.8)

0.141

10 (9.1)

89.1 (79.2–94.4)

< 0.001

 Deleted

28 (20.3)

13 (46.4)

50.8 (29.7–68.5)

10 (35.7)

67.9 (47.3–81.8)

 Aneuploid

80 (66.1)

24 (30)

70.0 (58.7–78.8)

0.734

3 (3.8)

96.3 (88.8–98.8)

< 0.001

 Di-tetraploid

41 (33.9)

14 (34.2)

65.8 (49.1–78.1)

10 (24.4)

70.8 (49.2–84.5)

 Favourable

69 (92)

16 (23.2)

73.9 (59.3–83.9)

0.78

5 (7.3)

94.2 (85.3–97.8)

0.147

 Unfavourable

6 (8)

2 (33.3)

66.7 (19.5–90.4)

2 (33.3)

66.7 (19.5–90.4)

 Observation

69 (25.8)

31 (44.9)

55.1 (42.6–65.9)

0.015

13 (18.8)

81.1 (69.7–88.6)

< 0.001

 Chemotherapy

90 (33.6)

29 (32.2)

66.8 (55.8–75.6)

23 (25.6)

73.2 (62.2–81.5)

 Resection of primary

76 (28.4)

14 (18.4)

81.1 (70.2–88.3)

4 (5.3)

94.3 (85.4–97.9)

 Chemotherapy + Resection of primary

19 (7.1)

4 (21.1)

76.6 (48.0–90.7)

2 (10.5)

94.7 (68.1–99.2)

 Radiotherapy + Other

14 (5.2)

5 (35.7)

64.3 (34.3–83.3)

4 (28.6)

71.4 (40.6–88.2)