Table 2 Characteristics of the 52 Single Nucleotide Polymorphisms (SNPs)
Chr | Gene | SNP name | QC | Alleles (M/m) | MAF | HWE p values | Missing (%) | GENO (AA/Aa/aa) |
|---|---|---|---|---|---|---|---|---|
1 | SELE | rs5361 | – | T/G | 9.9 | 0.005 | 5.4 | 814/161/18 |
2 | ORMDL1 | rs5742940 | – | G/A | 1.8 | 0.028 | 1.0 | 1004/33/2 |
3 | CACNA2D2 | rs12488468 | LCR | G/T | 48.2 | 0.014 | 25.9 | 187/432/159 |
3 | DOCK3 | rs76699816 | HWEd | G/A | 11.6 | < 0.001 | 8.7 | 779/138/42 |
4 | TLR1 | rs17616434 | – | T/C | 47.1 | 0.020 | 5.6 | 295/459/237 |
4 | TLR1 | rs2101521 | HWEd/LCR | G/A | 34.4 | < 0.001 | 15.6 | 444/274/168 |
4 | TLR1 | rs4833095 | HWEd | T/C | 48.4 | < 0.001 | 7.1 | 292/422/261 |
4 | TLR1 | rs5743595 | HWEd | A/G | 30.5 | < 0.001 | 5.8 | 506/363/120 |
4 | TLR10 | rs10004195 | HWEd/LCR | T/A | 46.2 | < 0.001 | 11.0 | 309/387/238 |
4 | TLR10 | rs4274855 | LCR | C/T | 29.4 | 1.000 | 22.5 | 408/334/72 |
4 | TLR2 | rs11736691 | GF | – | – | – | 100.0 | – |
4 | TLR6 | rs1039560 | – | T/C | 33.4 | 0.126 | 3.3 | 455/442/118 |
4 | TLR6 | rs5743789 | HWEd/LCR | A/T | 29.5 | < 0.001 | 19.8 | 460/268/114 |
5 | IL13 | rs1800925 | – | C/T | 18.4 | 0.721 | 4.6 | 668/300/34 |
5 | IL13 | rs1881457 | – | A/C | 18.4 | 0.720 | 2.8 | 681/305/35 |
5 | IL13 | rs20541 | HWEd | G/A | 14.5 | < 0.001 | 7.1 | 734/200/41 |
6 | IL17 | rs7741835 | – | C/T | 19.4 | 0.371 | 5.0 | 659/291/48 |
9 | DMRT1 | rs3812523 | – | A/G | 15.6 | 0.074 | 3.4 | 733/245/36 |
9 | IL33 | rs1342326 | – | A/C | 21.8 | 0.174 | 3.5 | 627/331/55 |
9 | IL33 | rs928413 | – | A/G | 30.8 | 0.397 | 4.3 | 486/418/101 |
11 | ANO9 | rs7482596 | HWEd | G/T | 13.3 | < 0.001 | 4.2 | 770/205/31 |
11 | ANO9 | rs7484182 | HWEd | T/C | 14.1 | < 0.001 | 4.1 | 758/215/34 |
11 | DHCR7 | rs1044482 | GF | – | – | – | 100.0 | – |
11 | GST-P1 | rs1695 | HWEd | A/G | 29.9 | < 0.001 | 6.2 | 521/338/126 |
11 | NADSYN1 | rs2186777 | – | A/C | 26.7 | 0.014 | 4.5 | 553/365/85 |
11 | SIGIRR | rs4074794 | HWEd | G/A | 19.5 | < 0.001 | 6.3 | 659/266/59 |
12 | IRAK3 | rs1152918 | – | C/T | 6.9 | 0.295 | 2.1 | 893/128/7 |
12 | IRAK3 | rs2701652 | – | G/C | 22.0 | 0.256 | 4.1 | 620/330/57 |
12 | ORMDL2 | rs7954619 | GF | – | – | – | 100.0 | – |
16 | IL4R | rs1801275 | – | A/G | 16.0 | 0.001 | 4.7 | 722/237/42 |
16 | IL4R | rs1805012 | HWEd | T/C | 5.8 | < 0.001 | 2.6 | 916/96/11 |
16 | IL4R | rs3024548 | HWEd/LCR | C/G | 46.4 | < 0.001 | 13.0 | 314/351/249 |
17 | ERBB2 | rs1058808 | – | G/C | 30.6 | 0.009 | 6.8 | 495/369/115 |
17 | ERBB2 | rs1136201 | HWEd | A/G | 13.8 | < 0.001 | 4.1 | 767/203/37 |
17 | ERBB2 | rs2934971 | GF | – | – | – | 100.0 | – |
17 | ERBB2 | rs2952155 | GF | – | – | – | 100.0 | – |
17 | ERBB2 | rs4252665 | – | C/T | 1.7 | 0.137 | 1.6 | 999/33/1 |
17 | GSDMA | rs3859192 | – | C/T | 37.9 | 0.028 | 6.5 | 398/423/161 |
17 | GSDMA | rs3894194 | – | G/A | 41.6 | 0.005 | 5.3 | 359/442/193 |
17 | GSDMA | rs7212938 | – | T/G | 44.2 | 0.039 | 4.8 | 326/463/211 |
17 | GSDMB | rs2305479 | – | C/T | 42.0 | 0.166 | 1.9 | 355/485/190 |
17 | GSDMB | rs2305480 | – | G/A | 40.2 | 0.088 | 3.8 | 371/466/173 |
17 | GSDMB | rs7216389 | HWEd | T/C | 42.2 | < 0.001 | 6.6 | 359/416/206 |
17 | LRRC3C | rs8065126 | HWEd/LCR | C/T | 38.3 | < 0.001 | 12.5 | 386/362/171 |
17 | LRRC3C | rs8079416 | – | T/C | 45.2 | 0.013 | 4.5 | 315/469/219 |
17 | MAP2K3 | rs10468608 | HWEd/LCR | C/T | 30.2 | < 0.001 | 19.8 | 462/251/129 |
17 | MAP2K3 | rs2363226 | GF | – | – | – | 100.0 | – |
17 | MAP2K4 | rs3760201 | HWEd/LCR | A/G | 32.9 | < 0.001 | 34.6 | 343/236/108 |
17 | ORMDL3 | rs8076131 | HWEd/LCR | A/G | 40.7 | < 0.001 | 15.9 | 333/382/168 |
17 | PGAP3 | rs1495102 | HWEd/LCR | C/T | 14.0 | < 0.001 | 17.7 | 697/92/75 |
17 | ZPBP2 | rs11557467 | GF | – | – | – | 100.0 | – |
X | IRAK1 | rs1059703 | HWEd | A/G | 25.5 | < 0.001 | 4.2 | 679/140/187 |