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Table 1 Results of the analyzed studies

From: Impact of the 2014 American Academy of Pediatrics recommendation and of the resulting limited financial coverage by the Italian Medicines Agency for palivizumab prophylaxis on the RSV-associated hospitalizations in preterm infants during the 2016–2017 epidemic season: a systematic review of seven Italian reports

Author, year [ref]

Study population and evaluations

Years reported

Results

1 | Capizzi, 2017 [31]

Infant hospitalizations for RSV (overall and preterm 29–36 wGA and 33–36 wGA) aged < 12 months

2014–2015, 2015–2016 and 2016–2017

2014–2015 and 2015–2016

Total of 137 and 109 hospitalizations

29–36 wGA = 6.6 and 7.3% RSV

33–36 wGA = 5.1 and 6.4% RSV

2016–2017

Total of 120 hospitalizations

29–36 wGA = 9.2% RSV

33–36 wGA = 8.3% RSV

2 | Picone, 2018 [33]

Preterm infant hospitalizations for bronchiolitis (30–32 wGA) aged < 12 months

2015–2016, 2016–2017 and 2017–2018

2015–2016 and 2017–2018

Bronchiolitis: 6/35 (17%) and 6/56 (10.7%) hospitalizations for bronchiolitis: 3/6 (3/35 pt.: 33%) and 3/6 (3/56 pt.: 5.3%)

Age at hospitalizations: 7 and 3 months

2016–2017

Bronchiolitis: 12/47 (26%)

Hospitalizations for bronchiolitis: 6/12 (6/47 pt.: 44%)

Age at hospitalizations: 4.3 months

3 | Wolfler [35]

Infant hospitalizations for RSV (overall and preterm < 27 wGA, 27–30 wGA and > 30 wGA) aged < 12 months

2014–2015, 2015–2016 and 2016–2017

2014–2015 and 2015–2016

Total hospitalizations for RSV: 88 and 115

< 27 wGA = 0 and 2 (1.7%)

27–30 wGA = 3 (3.4%) and 3 (2.6%)

> 30 wGA = 13 (14.8%) and 7 (6.1%)

2016–2017

Total hospitalizations for RSV: 111

< 27 wGA = 0

27–30 wGA = 6 (5.4%)

> 30 wGA =27 (24.3%)

4 | Di Mattia [34]

Preterm infant hospitalizations for RSV (< 29 wGA, 30–36 wGA and ≥ 37 wGA) with no age provided

2015–2016 and 2016–2017

2015–2016

< 29 wGA = 0

30–36 wGA = 8

≥37 wGA = 45

Total of 53 RSV

2016–2017

< 29 wGA = 0

30–36 wGA = 12

≥37 wGA = 51

Total of 63 RSV

P = 0.01

5 | Venafra [38]

Preterm infant hospitalizations for RSV (< 35 wGA)

2015–2016 and 2016–2017

2015–2016

RSV: 34/69 (48%)

Age at hospitalizations: 3.9 months

2016–2017

RSV: 62/112 (56%)

Age at hospitalizations: 3.4 months

6 | Vittucci [37]

Preterm infant hospitalizations for bronchiolitis (< 30 wGA and 30–37 wGA) aged < 12 months

2016–2017

2016–2017

≤29 wGA, treated = 3/3

30–37 wGA, treated, n = 2/29

RSV, treated, ≤37 wGA, n (%) = 1/5 (20%)

RSV+, not treated, 30–37 wGA, n (%) = 13/27 (48.2%)

7 | Santisi [36]

Infant hospitalizations for bronchiolitis (overall and preterm < 29 wGA, 29–32 wGA and 32–35 wGA) aged < 6 months and 6–12 months

2016–2017

2016–2017

< 6 months: 55.9% hospitalizations for bronchiolitis (60% RSV)

6–12 months: 25.9% hospitalizations for bronchiolitis (39% RSV)

< 29 wGA =1.5% hospitalizations for bronchiolitis

29–32 wGA =2.4% hospitalizations for bronchiolitis

32–35 wGA = 7% hospitalizations for bronchiolitis

  1. pt patients, RSV respiratory syncytial virus, wGA weeks of gestational age. The season of 2016–2017 is the endemic season of the AIFA limited palivizumab prophylaxis prescription coverage