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Table 2 Summary of the studies reporting the effects of Lactobacillus reuteri for the treatment of Infant Colic

From: Probiotics’ efficacy in paediatric diseases: which is the evidence? A critical review on behalf of the Italian Society of Pediatrics

Author and year Intervention Control Treatment duration Follow up Type of feeding
Savino F et al. 2010 [96] Lactobacillus reuteri DSM 17938 108 CFU
(5 drops)
Placebo
(identical formulation but without live bacteria)
21 days No follow up Exclusive breast-feeding
Szajewska H et al. 2013 [64] Lactobacillus reuteri DSM 17938 108 CFU
(5 drops)
Placebo
(identical formulation but without live bacteria)
21 days 8 days Exclusive or predominat (> 50%) breast-feeding
Chau K et al. 2015 [97] Lactobacillus reuteri DSM 17938 108 CFU
(5 drops)
Placebo
(same excipient ingredients but without live bacteria)
21 days No follow up Exclusive
breast-feeding
Sung V et al. 2014 [98] Lactobacillus reuteri DSM 17938 108 CFU (5 drops) Placebo
(maltodextrin in the same oil suspension)
1 month 5 months Formula feeding, breast feeding