Table 1 Key points of differentiation between RTH-α and RTH-β
TR types | RTH type | Mutation receptor | Clincal manifestations | Treatment |
|---|---|---|---|---|
TR-α1: Heart, muscle tissue TR-α2: Widely distributed TR-β1: Brain, liver, kidney TR-β2: Hypothalamus, pituitary gland | RTH-α | TR-α | Anemia, Constipation, Growth retardation, Developmental delay, Motor and Cognitive development delay | L-T4 |
RTH-β | TR-β | General, Pituitary and Peripheral RTH-β Vary from hyperthyroidism to hypothyroidism or simple goiter | L-T4 or L-T3, TRIAC, DT4, beta-blockers |