Fig. 2

Two girls with central precocious puberty with a slow rate progression before lockdown and acceleration during or after lockdown for COVID-19. Patient 1 started puberty at 7.5 years (November 2019: height 1.23 SDS, BMI 0.88 SDS; Tanner stage B2 PH1 AH1); the second pelvic sonography, February 2020 (a) is similar to the sonography at diagnosis (uterine length 43 mm and ovary volumes respectively 1.8 and 1.2 mL); the sonography in May 2020 (b) showing an acceleration in the tempo of puberty (height 1.29 SDS, BMI 0.91 SDS; Tanner stage B3–4 PH2 AH1; uterine length 52 mm, ovaries volume 4,9 and 4,0 mL). Patient 2 started puberty at 7.4 years (October 2019: height 1.17 SDS, BMI 0.69 SDS; Tanner stage B2 PH1 AH1); the second pelvic sonography in February 2020 (b) is similar to the sonography at diagnosis (uterine length 45 mm and ovaries volume respectively 3.8 and 3.7 mL); the sonography in May 2020 shows also an acceleration in the tempo of puberty (height 1.22 SDS, BMI 0.76 SDS; Tanner stage B3–4 PH1 AH1; uterine length 63 mm and ovary volumes respectively 6.4 and 8.8 mL)