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Table 1 Baseline demographic characteristics of preterm infants

From: Altered microstructure of the splenium of corpus callosum is associated with neurodevelopmental impairment in preterm infants with necrotizing enterocolitis

Variables

Without NEC

(n = 66)

With NEC

(n = 20)

p value

Maternal characteristics

 Maternal age (years)

34.14 ± 4.36

33.90 ± 5.12

0.857*

Mother’s education

0.134

 High, n (%)

3 (4.5)

2 (10)

 

 Intermediate, n (%)

52 (78.8)

16 (80)

 

 Low, n (%)

11 (16.7)

2 (10)

 

GDM (%)

7 (10.6)

0 (0)

0.193

PIH (%)

9 (13.6)

3 (15)

0.100

PPROM (%)

34 (51.5)

6 (30)

0.126

Histologic chorioamnionitis (%)

33 (50.0)

11 (55.0)

0.909

Neonatal characteristics

 Gestational age (weeks)

28.88 ± 2.65

27.03 ± 3.04

0.026*

 Birth weight (g)

1202.20 ± 256.40

985.50 ± 305.62

0.008

 Cesarean section (%)

52 (78.8)

18 (90)

0.340

 Male sex (%)

35 (53)

12 (60)

0.618

 Apgar score at 1 min

3.52 ± 1.69

2.70 ± 1.42

0.034*

 Apgar score at 5 min

6.42 ± 1.19

5.35 ± 1.42

0.001*

 Antenatal corticosteroid (%)

47 (71.2)

16 (80.0)

0.569

 Postnatal corticosteroid (%)

14 (21.2)

4 (20.0)

1.000

 RDS (%)

57 (86.4)

20 (100)

0.109

 Culture proven sepsis (%)

31 (47.0)

14 (70)

0.126

 Hypotension (%)

4 (6.1)

2 (10)

0.620

 Severe NEC (Bell stage ≧ 3) (%)

0

3 (15)

0.011

 PDA (%)

39 (59.1)

16 (80)

0.114

 BPD moderate and severe (%)

14 (21.2)

5 (25)

0.762

 ROP (%)

30 (45.5)

10 (50)

0.377

 TPN days

32.98 ± 26.94

52.00 ± 28.58

0.003*

Infants characteristics on PMA at MRI

 PMA at MRI (weeks)

36.91 ± 1.71

37.90 ± 2.45

0.210*

 Weight at MRI (g)

2515.91 ± 514.12

2517.00 ± 730.57

0.368*

 Height at MRI (cm)

45.97 ± 3.41 (n = 65)

45.93 ± 4.04

0.697*

 Head circumference at MRI (cm)

33.18 ± 1.82

32.88 ± 1.67

0.380*

  1. Data are expressed as mean ± standard deviation or number (%)
  2. Abbreviations: NEC necrotizing enterocolitis, GDM gestational diabetes mellitus, PIH pregnancy-induced hypertension, PPROM preterm premature rupture of the membranes, PDA patent ductus arteriosus, BPD bronchopulmonary dysplasia, ROP retinopathy of prematurity, TPN total parenteral nutrition, PMA postmenstrual age, MRI magnetic resonance imaging, RDS respiratory distress syndrome
  3. *For non-normal distribution, Mann-Whitney U Test was used to compare the groups