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Table 1 Baseline demographic characteristics of preterm infants

From: Altered microstructure of the splenium of corpus callosum is associated with neurodevelopmental impairment in preterm infants with necrotizing enterocolitis

Variables Without NEC
(n = 66)
With NEC
(n = 20)
p value
Maternal characteristics
 Maternal age (years) 34.14 ± 4.36 33.90 ± 5.12 0.857*
Mother’s education 0.134
 High, n (%) 3 (4.5) 2 (10)  
 Intermediate, n (%) 52 (78.8) 16 (80)  
 Low, n (%) 11 (16.7) 2 (10)  
GDM (%) 7 (10.6) 0 (0) 0.193
PIH (%) 9 (13.6) 3 (15) 0.100
PPROM (%) 34 (51.5) 6 (30) 0.126
Histologic chorioamnionitis (%) 33 (50.0) 11 (55.0) 0.909
Neonatal characteristics
 Gestational age (weeks) 28.88 ± 2.65 27.03 ± 3.04 0.026*
 Birth weight (g) 1202.20 ± 256.40 985.50 ± 305.62 0.008
 Cesarean section (%) 52 (78.8) 18 (90) 0.340
 Male sex (%) 35 (53) 12 (60) 0.618
 Apgar score at 1 min 3.52 ± 1.69 2.70 ± 1.42 0.034*
 Apgar score at 5 min 6.42 ± 1.19 5.35 ± 1.42 0.001*
 Antenatal corticosteroid (%) 47 (71.2) 16 (80.0) 0.569
 Postnatal corticosteroid (%) 14 (21.2) 4 (20.0) 1.000
 RDS (%) 57 (86.4) 20 (100) 0.109
 Culture proven sepsis (%) 31 (47.0) 14 (70) 0.126
 Hypotension (%) 4 (6.1) 2 (10) 0.620
 Severe NEC (Bell stage 3) (%) 0 3 (15) 0.011
 PDA (%) 39 (59.1) 16 (80) 0.114
 BPD moderate and severe (%) 14 (21.2) 5 (25) 0.762
 ROP (%) 30 (45.5) 10 (50) 0.377
 TPN days 32.98 ± 26.94 52.00 ± 28.58 0.003*
Infants characteristics on PMA at MRI
 PMA at MRI (weeks) 36.91 ± 1.71 37.90 ± 2.45 0.210*
 Weight at MRI (g) 2515.91 ± 514.12 2517.00 ± 730.57 0.368*
 Height at MRI (cm) 45.97 ± 3.41 (n = 65) 45.93 ± 4.04 0.697*
 Head circumference at MRI (cm) 33.18 ± 1.82 32.88 ± 1.67 0.380*
  1. Data are expressed as mean ± standard deviation or number (%)
  2. Abbreviations: NEC necrotizing enterocolitis, GDM gestational diabetes mellitus, PIH pregnancy-induced hypertension, PPROM preterm premature rupture of the membranes, PDA patent ductus arteriosus, BPD bronchopulmonary dysplasia, ROP retinopathy of prematurity, TPN total parenteral nutrition, PMA postmenstrual age, MRI magnetic resonance imaging, RDS respiratory distress syndrome
  3. *For non-normal distribution, Mann-Whitney U Test was used to compare the groups