Altered microstructure of the splenium of corpus callosum is associated with neurodevelopmental impairment in preterm infants with necrotizing enterocolitis

Table 4 Developmental assessment of preterm infants at 18 months of corrected age*

Variables	Cognitive impairment		Language impairment		Motor impairment
Variables	Odds ratio (95% C.I)	p value	Odds ratio (95% C.I)	p value	Odds ratio (95% C.I)	p value
NEC	1.95 (0.20–18.79)	0.561	1.50 (0.29–7.59)	0.622	58.26 (7.80–435.12)	< 0.001
GA (weeks)	0.92 (0.59–1.43)	0.726	0.85 (0.62–1.17)	0.321	1.20 (0.85–1.70)	0.290
PMA at MRI (weeks)	1.11 (0.69–1.85)	0.649	1.23 (0.87–1.76)	0.238	0.98 (0.65–1.47)	0.932
Sex (Male)	8.25 (0.57–57.30)	0.137	1.78 (0.45–7.04)	0.411	2.57 (0.54–12.25)	0.236
BPD moderate and severe	1.78 (0.12–25.60)	0.184	10.43 (0.75–144.1)	0.080	0.23 (0.01–2.92)	0.262
Maternal education**	0.49 (0.04–5.81)	0.572	0.53 (0.08–3.21)	0.491	2.87 (0.26–31.21)	0.387

Abbreviations: C. I, confidence interval; NEC, necrotizing enterocolitis; GA, gestational age; PMA, postmenstrual age; MRI, magnetic resonance imaging; BPD, bronchopulmonary dysplasia
^*Includes 75 preterm infants (19 with NEC, 56 without NEC) out of 86 preterm infants
**Defined as mothers with college graduate or higher educational level

ISSN: 1824-7288