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Table 1 Main characteristics of the three groups with absence of pubertal signs at a chronological age of 13 years (females) and of 14 years (males)

From: Current clinical management of constitutional delay of growth and puberty

 

CDGP

FHH

PHH

Bone age f (ys)

< 12

< 12

> 12

Bone age m (ys)

< 13

< 13

> 13

Familar history

yes

no

no

Intercurrent disease

no

yes

no

cryptorchidism, or testes volume ≤ 1 ml

no

no

no/yes

BMI

normal

low

normal/high

Psychological difficulties

no/yes

no/yes

no/yes

FSH

normal/low

normal/low

low

GnRH test

prepubertal

prepubertal

prepubertal

Inibin B

normal/low

normal/low

low

FSH-iB

normal

normal

low

Genetic testing +

no/yes

no

no/yes

  1. CDGP: Constitutional delay of growth and puberty; FHH: Funtional hypogonadotropic hypogonadism; PHH: Permanent hypogonadotropic hypogonadism; FSH: Follicle-Stimulating Hormone; FSH-iB: FSH stimulated inhibin B concentrations