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Table 1 Main characteristics of the three groups with absence of pubertal signs at a chronological age of 13 years (females) and of 14 years (males)

From: Current clinical management of constitutional delay of growth and puberty

  CDGP FHH PHH
Bone age f (ys) < 12 < 12 > 12
Bone age m (ys) < 13 < 13 > 13
Familar history yes no no
Intercurrent disease no yes no
cryptorchidism, or testes volume ≤ 1 ml no no no/yes
BMI normal low normal/high
Psychological difficulties no/yes no/yes no/yes
FSH normal/low normal/low low
GnRH test prepubertal prepubertal prepubertal
Inibin B normal/low normal/low low
FSH-iB normal normal low
Genetic testing + no/yes no no/yes
  1. CDGP: Constitutional delay of growth and puberty; FHH: Funtional hypogonadotropic hypogonadism; PHH: Permanent hypogonadotropic hypogonadism; FSH: Follicle-Stimulating Hormone; FSH-iB: FSH stimulated inhibin B concentrations