Table 4 Therapeutic management. ARB: angiotensin II receptor blocker (losartan). PDA: patent ductus arteriosus. ASD: atrial sept defect. VSD: ventricular sept defect. NR: not reported
From: Neonatal presentation of Loeys-Dietz syndrome: two case reports and review of the literature
Report | Medical therapy | Surgery | Surgical treatment | Surgical timing (age) |
|---|---|---|---|---|
Choo JTL et al | / | No | / | / |
Ilyn VN et al | Beta-blocker | Yes | Aneurism resection, repair of aortic coarctation, subclavian ligation | 1 year |
Muramatsu Y et al | ACE-inhibitor | Yes | Pulmonary artery banding - ASD and VSD closure, pulmonary artery plastic | 12 days - 42 days |
Kuppler KM et al | / | No | / | / |
Wisniewski K et al | Beta-blocker, ARB | Yes | PDA closure - Valve sparing aortic root replacement | 40 days - 8 months |
Valenzuela I et al | Beta-blocker, ARB | No | / | / |
Ozawa H et al | ARB | Yes | Bilateral pulmonary artery banding | 9 days (urgent) |
Viassolo V et al | / | No | / | / |
Yetman AT et al. [1] | Beta-blocker, ACE-inhibitor | No | / | / |
Yetman AT et al. [2] | ACE-inhibitor | Yes | PDA ligation | NR |
Yetman AT et al. [3] | / | Yes | Aortic valve replacement, aortic replacement | 9 years |
Yetman AT et al. [4] | ACE-inhibitor | Yes | Valve sparing surgery | 2 years |
Yetman AT et al. [5] | / | Yes | Valve sparing surgery | 3 years |
Chung BHY et al | ARB | No | / | / |
Patient 1 | ARB | No | / | / |
Patient 2 | / | No | / | / |